Literature summary for 1.1.1.1 extracted from

Devi, P.G.; Chakraborty, P.K.; Dasgupta, D.
Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3 (2009), J. Biol. Inorg. Chem., 14, 347-359.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Hep-G2 cells	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
chromomycin A3	-	Saccharomyces cerevisiae
dipicolinic acid	Zn2+ chelator and inhibitor of ADH	Saccharomyces cerevisiae
mithramycin	-	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
7.75	-	ethanol	in 50 mM Tris-HCl, pH 8.0 at 25°C	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Saccharomyces cerevisiae	5737	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	contains Zn2+	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P00330	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ethanol + NAD+	-	Saccharomyces cerevisiae	acetaldehyde + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
ADH	-	Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
143	-	ethanol	in 50 mM Tris-HCl, pH 8.0 at 25°C	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.025	-	mithramycin	in 50 mM Tris-HCl, pH 8.0 at 25°C	Saccharomyces cerevisiae
0.038	-	mithramycin	in 50 mM Tris-HCl, pH 8.0 at 25°C	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)