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Literature summary for 1.1.1.1 extracted from

  • Staab, C.A.; Hellgren, M.; Hoeoeg, J.O.
    Medium- and short-chain dehydrogenase/reductase gene and protein families: Dual functions of alcohol dehydrogenase 3: implications with focus on formaldehyde dehydrogenase and S-nitrosoglutathione reductase activities (2008), Cell. Mol. Life Sci., 65, 3950-3960.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
S-nitrosoglutathione ADH3-mediated alcohol oxidation is promoted in the presence of S-nitrosoglutathione Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
dodecanoic acid inhibits ADH3 irrespective of substrate Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
nucleus
-
Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ 2 atoms are included in each 40 kDa subunit, while one of the zinc ions is considered to serve a structural function only, the other zinc ion functions as a Lewis acid and activates the substrate in the active site, which is located in a cleft between the catalytic and the coenzyme binding domain Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a primary alcohol + NAD+ Mus musculus ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM an aldehyde + NADH + H+
-
?
all-trans-retinol + NAD+ Mus musculus
-
all-trans-retinal + NADH
-
?
octanol + NAD+ Mus musculus
-
octanal + NADH
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
additional information ADH3 is expressed ubiquitously and with relatively little inter-tissue variation in mammals, in contrast to other ADHs Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a primary alcohol + NAD+ ADH3 is involved in multiple cellular pathways, as diverse as formaldehyde detoxification, retinoid metabolism and NO homeostasis, ADH3 is considered to play only a minor role in hepatic alcohol metabolism because ethanol concentrations rarely exceed 50 mM Mus musculus an aldehyde + NADH + H+
-
?
all-trans-retinol + NAD+
-
Mus musculus all-trans-retinal + NADH
-
?
octanol + NAD+
-
Mus musculus octanal + NADH
-
?

Synonyms

Synonyms Comment Organism
ADH
-
Mus musculus
ADH3
-
Mus musculus
alcohol dehydrogenase 3
-
Mus musculus
alcohol dependent dehydrogenase
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NADH
-
Mus musculus