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Literature summary for 1.1.1.1 extracted from

  • Jelski, W.; Zalewski, B.; Szmitkowski, M.
    Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer (2008), J. Clin. Lab. Anal., 22, 204-209.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
blood serum the total ADH activity is significantly higher (44%) among patients with cancer than healthy ones. The activity of class I ADH isoenzymes is elevated only in the serum of patients with metastatic liver cancer. This increase of activity seems to be caused by the enzyme released from liver cancer cells and primary tumors originating in other organs Homo sapiens
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hepatocyte the activities of total alcohol dehydrogenase, aldehyde dehydrogenase and class I alcohol dehydrogenase isoenzyme between cancer liver tissues and healthy hepatocytes might be a factor in ethanol metabolism disorders which can intensify carcinogenesis Homo sapiens
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liver the activities of total alcohol dehydrogenase, aldehyde dehydrogenase and class I alcohol dehydrogenase isoenzyme between cancer liver tissues and healthy hepatocytes might be a factor in ethanol metabolism disorders which can intensify carcinogenesis Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n-butanol + NAD+
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 Homo sapiens n-butanal + NADH
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 ?