Literature summary for 1.1.1.1 extracted from

Sit, S.Y.; Parker, R.A.; Motoc, I.; Han, W.; Balasubramanian, N.
Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (1990), J. Med. Chem., 33, 2982-2999.

Search for more literature for 1.1.1.1

Application

Application	Comment	Organism
synthesis	production of (3R,5S)-6-benzyloxy-3,5-dihydroxy-hexanoic acid ethyl ester, which is a key chiral intermediate for anticholesterol drugs that act by inhibition of hydroxy methyl glutaryl coenzyme A reductase	Acinetobacter calcoaceticus

Organism

Organism	UniProt	Comment	Textmining
Acinetobacter calcoaceticus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-benzyloxy-3,5-dioxo-hexanoic acid ethyl ester + NADH + H+	-	Acinetobacter calcoaceticus	(3R,5S)-6-benzyloxy-3,5-dihydroxy-hexanoic acid ethyl ester + NAD+	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
33	-	-	Acinetobacter calcoaceticus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.9	-	-	Acinetobacter calcoaceticus

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Acinetobacter calcoaceticus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)