Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.1 extracted from

  • Espinosa, A.; Clark, D.; Stanley, S.L., Jr.
    Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents (2004), J. Antimicrob. Chemother., 54, 56-59.
    View publication on PubMed
Search for more literature for 1.1.1.1

Application

Application Comment Organism
medicine isozyme ADH2 is a target for anti-amoebic agents Entamoeba histolytica

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Entamoeba histolytica

Inhibitors

Inhibitors Comment Organism Structure
cyclobutyl carbinol complete inhibition in vitro at 890 nM, anti-amoebic activity on trophozoites by growth inhibition of recombinant Escherichia coli cells Entamoeba histolytica
cyclopropyl carbinol complete inhibition in vitro at 1820 nM, anti-amoebic activity on trophozoites by growth inhibition of recombinant Escherichia coli cells Entamoeba histolytica

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
-
 alcohol dehydrogenase 2
-
Entamoeba histolytica HM1:1MSS
-
 alcohol dehydrogenase 2
-

Source Tissue

Source Tissue Comment Organism Textmining
trophozoite
-
 Entamoeba histolytica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NADH + H+
-
 Entamoeba histolytica ethanol + NAD+
-
 ?
acetaldehyde + NADH + H+
-
 Entamoeba histolytica HM1:1MSS ethanol + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
ADH2
-
 Entamoeba histolytica

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Entamoeba histolytica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Entamoeba histolytica