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Literature summary for 1.1.1.1 extracted from

  • Lamed, R.; Zeikus, J.G.
    Ethanol production by thermophilic bacteria: relationship between fermentation product yields of and catabolic enzyme activities in Clostridium thermocellum and Thermoanaerobium brockii (1980), J. Bacteriol., 144, 569-578.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Thermoanaerobacter brockii
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethanol + NAD+
-
 Thermoanaerobacter brockii acetaldehyde + NADH + H+
-
 r
ethanol + NADP+
-
 Thermoanaerobacter brockii acetaldehyde + NADPH + H+
-
 r
additional information ethanol dehydrogenase activity of Thermoanaerobium brockii is both NAD and NADP linked, reversible, and not inhibited by low levels of reaction products Thermoanaerobacter brockii ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Thermoanaerobacter brockii
NADP+
-
 Thermoanaerobacter brockii

General Information

General Information Comment Organism
physiological function different fermentation product yields observed in different ethanol-producing thernophiles that employ the phosphoroclastic pathway for pyruvate metabolism are related to the specific activities and the direction of specific oxidoreductases that control electron flow. Thermoanaerobium brockii extracts contain reversible NAD- and NADP-linked alcohol dehydrogenase activities that are not effectively inhibited by low NAD(P) or ethanol Thermoanaerobacter brockii