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Literature summary for 1.1.1.1 extracted from

  • Winberg, J.O.; Hovik, R.; McKinley-McKee, J.S.; Juan, E.; Gonzalez-Duarte, R.
    Biochemical properties of alcohol dehydrogenase from Drosophila lebanonensis (1986), Biochem. J., 235, 481-490.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
2,2,2-Trifluoroethanol competitive towards ethanol Scaptodrosophila lebanonensis
2-Chloroethanol competitive towards ethanol Scaptodrosophila lebanonensis
Cibacron blue competitive towards NAD+ Scaptodrosophila lebanonensis
imidazole pure competitive inhibition towards ethanol and (R)-(+)-phenylethanol Scaptodrosophila lebanonensis
isoburyramide competitive towards ethanol and butan-2-ol Scaptodrosophila lebanonensis
NADH competitive towards NAD+ Scaptodrosophila lebanonensis
pyrazole competitive towards ethanol Scaptodrosophila lebanonensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 NAD+ oxidation of ethanol Scaptodrosophila lebanonensis
0.028
-
 NAD+ oxidation of propan-2-ol Scaptodrosophila lebanonensis
0.72
-
 Cyclohexanol
-
 Scaptodrosophila lebanonensis
0.81
-
 4-methylpentan-1-ol
-
 Scaptodrosophila lebanonensis
0.85
-
 S-(-)-trans-bicyclo(2.2.1)-heptanol
-
 Scaptodrosophila lebanonensis
0.95
-
 S-(-)-2-methylbutan-1-ol
-
 Scaptodrosophila lebanonensis
1
-
 cis-4-methylcyclohexanol
-
 Scaptodrosophila lebanonensis
1.1
-
 2-propanol
-
 Scaptodrosophila lebanonensis
1.1
-
 trans-4-methylcyclohexanol
-
 Scaptodrosophila lebanonensis
1.2
-
 R-(+)-cis-verbenol
-
 Scaptodrosophila lebanonensis
1.5
-
 R-(+)-trans-bicyclo(2.2.1)-heptanol
-
 Scaptodrosophila lebanonensis
1.9
-
 butan-1-ol
-
 Scaptodrosophila lebanonensis
1.9
-
 propan-1-ol
-
 Scaptodrosophila lebanonensis
2.7
-
 2-methylpropan-1-ol
-
 Scaptodrosophila lebanonensis
3.4
-
 R-(+)-1-phenylethanol
-
 Scaptodrosophila lebanonensis
3.8
-
 S-(-)-cis-bicyclo(2.2.1)-heptanol
-
 Scaptodrosophila lebanonensis
3.9
-
 S-(-)-1-phenylethanol
-
 Scaptodrosophila lebanonensis
4.1
-
 pentan-1-ol
-
 Scaptodrosophila lebanonensis
6
-
 ethanol
-
 Scaptodrosophila lebanonensis
6.2
-
 ethanol
-
 Scaptodrosophila lebanonensis
6.6
-
 heptan-4-ol
-
 Scaptodrosophila lebanonensis
7.4
-
 hexan-1-ol
-
 Scaptodrosophila lebanonensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
 2 * 28000, SDS-PAGE Scaptodrosophila lebanonensis
56000
-
 gel filtration Scaptodrosophila lebanonensis

Organism

Organism UniProt Comment Textmining
Scaptodrosophila lebanonensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-methylbutan-1-ol + NAD+
-
 Scaptodrosophila lebanonensis (S)-2-methyl-butanal + NADH + H+
-
 ?
2-methylbutan-1-ol + NAD+
-
 Scaptodrosophila lebanonensis ? + NADH
-
 ?
2-methylpropan-1-ol + NAD+
-
 Scaptodrosophila lebanonensis 2-methyl-propan-1-one + NADH
-
 ?
3-methylbutan-2-ol + NAD+ R-(-)-3-methylbutan-2-ol and S-(+)-3-methylbutan-2-ol Scaptodrosophila lebanonensis 3-methylbutan-2-one + NADH
-
 ?
4-methyl-1-pentanol + NAD+
-
 Scaptodrosophila lebanonensis 4-methyl-1-pentanal + NADH
-
 ?
butan-2-ol + NAD+
-
 Scaptodrosophila lebanonensis butan-2-one + NADH
-
 ?
butanol + NAD+
-
 Scaptodrosophila lebanonensis butyraldehyde + NADH
-
 ?
cis-4-methylcyclohexanol + NAD+
-
 Scaptodrosophila lebanonensis 4-methylcyclohexanone + NADH
-
 ?
cyclohexanol + NAD+
-
 Scaptodrosophila lebanonensis cyclohexanone + NADH
-
 ?
ethanol + NAD+
-
 Scaptodrosophila lebanonensis acetaldehyde + NADH + H+
-
 r
ethanol + NAD+ 100% activity Scaptodrosophila lebanonensis acetaldehyde + NADH + H+
-
 r
heptan-2-ol + NAD+
-
 Scaptodrosophila lebanonensis heptan-2-one + NADH
-
 ?
heptan-4-ol + NAD+
-
 Scaptodrosophila lebanonensis heptan-4-one + NADH
-
 ?
hexan-1-ol + NAD+
-
 Scaptodrosophila lebanonensis n-hexanal + NADH
-
 ?
hexan-2-ol + NAD+
-
 Scaptodrosophila lebanonensis 2-hexanone + NADH
-
 ?
octan-2-ol + NAD+
-
 Scaptodrosophila lebanonensis octan-2-one + NADH
-
 ?
pentan-2-ol + NAD+
-
 Scaptodrosophila lebanonensis 2-pentanone + NADH
-
 ?
pentanol + NAD+
-
 Scaptodrosophila lebanonensis n-pentanal + NADH
-
 ?
phenylethanol + NAD+ R-(+)-phenylethanol and S-(-)-phenylethanol Scaptodrosophila lebanonensis phenylacetaldehyde + NADH
-
 ?
propan-2-ol + NAD+
-
 Scaptodrosophila lebanonensis acetone + NADH
-
 ?
propanol + NAD+
-
 Scaptodrosophila lebanonensis propionaldehyde + NADH + H+
-
 ?
R-(+)-1-phenylethanol + NAD+
-
 Scaptodrosophila lebanonensis 1-phenylethanone + NADH
-
 ?
R-(+)-cis-verbenol + NAD+
-
 Scaptodrosophila lebanonensis ? + NADH
-
 ?
R-(+)-trans-bicyclo(2.2.1)-heptanol + NAD+ R-(+)-trans-bicyclo(2.2.1)-heptanol and S-(-)-trans-bicyclo(2.2.1)-heptanol Scaptodrosophila lebanonensis R-(+)-trans-bicyclo(2.2.1)-heptanal + NADH
-
 ?
S-(-)-1-phenylethanol + NAD+
-
 Scaptodrosophila lebanonensis 1-phenylethanone + NADH
-
 ?
S-(-)-cis-bicyclo(2.2.1)-heptanol + NAD+
-
 Scaptodrosophila lebanonensis S-(-)-cis-bicyclo(2.2.1)-heptanal + NADH
-
 ?
S-(-)-trans-bicyclo(2.2.1)-heptanol + NAD+ 1054% activity compared to ethanol Scaptodrosophila lebanonensis S-(-)-cis-bicyclo(2.2.1)-heptanal + NADH + H+
-
 r
trans-4-methylcyclohexanol + NAD+
-
 Scaptodrosophila lebanonensis 4-methylcyclohexanone + NADH
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 28000, SDS-PAGE Scaptodrosophila lebanonensis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Scaptodrosophila lebanonensis
NADH
-
 Scaptodrosophila lebanonensis