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Literature summary for 1.1.1.1 extracted from
- A genuine organ specific alcohol dehydrogenase from hamster testes: isolation, characterization and developmental changes (1988), Biochem. Biophys. Res. Commun., 156, 38-45.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | mixed type inhibition | Mesocricetus auratus |  |
| 12-hydroxydodecanoate | - |
Mesocricetus auratus | |
| 4-methoxypyrazole | competitive | Mesocricetus auratus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 41000 | - |
2 * 41000, SDS-PAGE | Mesocricetus auratus |
| 80000 | - |
gel filtration | Mesocricetus auratus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mesocricetus auratus | involvement in the development of male hamster reproductive system | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocricetus auratus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mesocricetus auratus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | activity increases during the prepubertal development | Mesocricetus auratus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4 | - |
- |
Mesocricetus auratus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 12-hydroxydodecanoate + NAD+ | oxidized at pH 10, not oxidized at pH 7.5 | Mesocricetus auratus | 12-oxododecanoic acid + NADH | - |
? | |
| all-trans-retinol + NAD+ | - |
Mesocricetus auratus | all-trans-retinal + NADH | - |
? | |
| benzyl alcohol + NAD+ | - |
Mesocricetus auratus | benzaldehyde + NADH | - |
? | |
| butan-2-ol + NAD+ | - |
Mesocricetus auratus | butan-2-one + NADH | - |
? | |
| butanol + NAD+ | - |
Mesocricetus auratus | butyraldehyde + NADH | - |
? | |
| cyclohexanol + NAD+ | - |
Mesocricetus auratus | cyclohexanone + NADH | - |
? | |
| ethanol + NAD+ | - |
Mesocricetus auratus | acetaldehyde + NADH | - |
? | |
| hexan-1-ol + NAD+ | - |
Mesocricetus auratus | n-hexanal + NADH | - |
? | |
| additional information | involvement in the development of male hamster reproductive system | Mesocricetus auratus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 41000, SDS-PAGE | Mesocricetus auratus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.3 | - |
all-trans retinol | - |
Mesocricetus auratus | |
| 1.37 | - |
benzyl alcohol | - |
Mesocricetus auratus | |
| 2.03 | - |
Cyclohexanol | - |
Mesocricetus auratus | |
| 2.43 | - |
12-hydroxydodecanoate | - |
Mesocricetus auratus | |
| 3.03 | - |
1-Hexanol | - |
Mesocricetus auratus | |
| 4.75 | - |
2-butanol | - |
Mesocricetus auratus | |
| 7.5 | - |
1-butanol | - |
Mesocricetus auratus | |
| 7.75 | - |
NAD+ | oxidation of ethanol | Mesocricetus auratus | |
| 8 | - |
ethanol | - |
Mesocricetus auratus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | 10 | - |
Mesocricetus auratus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mesocricetus auratus | |
| NADH | - |
Mesocricetus auratus | |
| NADP+ | no activity as coenzyme | Mesocricetus auratus | |
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