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Literature summary for 1.1.1.1 extracted from
- Horse liver alcohol dehydrogenase SS: purification and characterization of the homogenous isoenzyme (1977), Arch. Biochem. Biophys., 183, 73-82.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
hexaldehyde | - |
Equus caballus |  |
| 0.03 | - |
Hexanol | - |
Equus caballus | |
| 0.031 | - |
3-oxo-5beta-androstan-17beta-ol | - |
Equus caballus | |
| 0.046 | - |
benzyl alcohol | - |
Equus caballus | |
| 0.047 | - |
5beta-Pregnan-21-ol-3,20-dione hemisuccinate | - |
Equus caballus | |
| 0.06 | - |
Butyraldehyde | - |
Equus caballus | |
| 0.091 | - |
butanol | - |
Equus caballus | |
| 0.148 | - |
benzaldehyde | - |
Equus caballus | |
| 1.24 | - |
propionaldehyde | - |
Equus caballus | |
| 2.9 | - |
Propanol | - |
Equus caballus | |
| 6 | - |
acetaldehyde | - |
Equus caballus | |
| 14.1 | - |
cyclohexanone | - |
Equus caballus | |
| 40 | - |
ethanol | - |
Equus caballus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | contains 4 zinc atoms per molecule | Equus caballus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
SS isoenzyme | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Equus caballus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Equus caballus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3.2 | - |
reduction of 3-oxo-5beta-androstan-17beta-ol | Equus caballus |
| 4.2 | - |
reduction of cyclohexanone | Equus caballus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-oxo-5beta-androstan-17beta-ol + NADH | - |
Equus caballus | 3beta,17beta-dihydroxy-5beta-androstane + NAD+ | - |
? | |
| 5beta-pregnan-21-ol-3,20-dione hemisuccinate + NAD+ | - |
Equus caballus | 5beta-pregnan-3,20,21-trione hemisuccinate + NADH + H+ | - |
? | |
| acetaldehyde + NADH + H+ | - |
Equus caballus | ethanol + NAD+ | - |
r | |
| benzyl alcohol + NAD+ | - |
Equus caballus | benzaldehyde + NADH | - |
? | |
| butanol + NAD+ | - |
Equus caballus | butyraldehyde + NADH | - |
? | |
| butyraldehyde + NADH | - |
Equus caballus | n-butanol + NAD+ | - |
r | |
| cyclohexanone + NADH | - |
Equus caballus | cyclohexanol + NAD+ | - |
? | |
| ethanol + NAD+ | - |
Equus caballus | acetaldehyde + NADH | - |
r | |
| hexanol + NAD+ | - |
Equus caballus | n-hexanal + NADH | - |
? | |
| propionaldehyde + NADH | - |
Equus caballus | propanol + NAD+ | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.78 | - |
benzyl alcohol | - |
Equus caballus | |
| 0.9 | - |
5beta-Pregnan-21-ol-3,20-dione hemisuccinate | - |
Equus caballus | |
| 0.94 | - |
Butyl alcohol | - |
Equus caballus | |
| 0.99 | - |
hexyl alcohol | - |
Equus caballus | |
| 1.17 | - |
Propyl alcohol | - |
Equus caballus | |
| 1.27 | - |
ethanol | - |
Equus caballus | |
| 2.05 | - |
3-oxo-5beta-androstan-17beta-ol | - |
Equus caballus | |
| 5.9 | - |
cyclohexanone | - |
Equus caballus | |
| 29.5 | - |
benzaldehyde | - |
Equus caballus | |
| 31.8 | - |
acetaldehyde | - |
Equus caballus | |
| 35.4 | - |
Butyraldehyde | - |
Equus caballus | |
| 41.9 | - |
propionaldehyde | - |
Equus caballus | |
| 56.6 | - |
hexaldehyde | - |
Equus caballus | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | preferred substrate | Equus caballus | |
| NADH | preferred coenzyme | Equus caballus | |
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