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Literature summary for 1.1.1.1 extracted from

  • Dafeldecker, W.P.; Meadow, P.E.; Pares, X.; Vallee, B.L.
    Simian liver alcohol dehydrogenase: isolation and characterization of isoenzymes from Macaca mulatta (1981), Biochemistry, 20, 6729-6734.
    View publication on PubMed
Search for more literature for 1.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Macaca mulatta
2,2'-bipyridine
-
 Macaca mulatta
4-Methylpyrazole
-
 Macaca mulatta
EDTA
-
 Macaca mulatta
pyrazole organism has a pyrazole-sensitive isoenzyme and a pyrazole-insensitive enzyme Macaca mulatta

Metals/Ions

Metals/Ions Comment Organism Structure
copper contains 0.5 mol of copper per mol of enzyme Macaca mulatta
Zinc contains 3.7-4.2 mol of zinc per mol of enzyme Macaca mulatta

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000 77000 equilibrium sedimentation Macaca mulatta

Organism

Organism UniProt Comment Textmining
Macaca mulatta
-
 cationic pyrazole-sensitive isoenzyme, anodic pyrazole-sensitive isoenzyme and cathionic pyrazole-in sensitive isoenzyme
-

Purification (Commentary)

Purification (Comment) Organism
-
 Macaca mulatta

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Macaca mulatta
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NADH + H+
-
 Macaca mulatta ethanol + NAD+
-
 r
cyclohexanol + NAD+ reaction is catalyzed by the cathodic pyrazole-sensitive enzyme, no activity with the cathodic pyrazole-insensitive enzyme and by the anodic pyrazole-insensitive enzyme Macaca mulatta cyclohexanone + NADH
-
 ?
ethanol + NAD+
-
 Macaca mulatta acetaldehyde + NADH
-
 r
methanol + NAD+ reaction is catalyzed by the cathodic pyrazole-sensitive enzyme, no activity by the cathodic pyrazole-insensitive enzyme and by the anodic pyrazole-insensitive enzyme Macaca mulatta formaldehyde + NADH + H+
-
 ?
octan-1-ol + NAD+
-
 Macaca mulatta n-octanal + NADH
-
 ?
pentanal + NAD+
-
 Macaca mulatta pentanone + NADH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.6
-
 pyrazole-sensitive enzyme Macaca mulatta
11.2
-
 oxidation of ethanol, pyrazole-sensitive enzyme form Macaca mulatta

pH Range

pH Minimum pH Maximum Comment Organism
9 12 pH 9.0: about 25% of maximal activity, pH 12.0: about 80% of maximal activity, pyrazole-sensitive enzyme Macaca mulatta
10 11 pH 10.0: about 50% of maximal activity, pH 11.0: about 75% of maximal activity, pyrazole-insensitive enzyme Macaca mulatta

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Macaca mulatta
NADH
-
 Macaca mulatta