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Ligand precorrin-8X

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for precorrin-8X

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.4.99.60

Precorrin-8X = ?

3208

-

5.4.99.61

Precorrin-8X = ?

3210, 3212, 3209

-

5.4.99.61

Precorrin-8X = Hydrogenobyrinate

653928

-

5.4.99.61

2 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.4.99.60

Precorrin-8X = ?

3208

-

5.4.99.60

Precorrin-8X = Hydrogenobyrinate

3208

-

5.4.99.61

Precorrin-8X = ?

3210, 3212, 3209

-

5.4.99.61

Precorrin-8X = Hydrogenobyrinate

3212, 3209, 3210, 3211, 653928

-

5.4.99.60

2 entries

5.4.99.61

2 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.132

Adenosyl-L-methionine + precorrin-6Y = Adenosyl-L-homocysteine + precorrin-8X + CO2

15273

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

5.4.99.61

0.00142

-

-

3210

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.4.99.61

0.91

-

-

3210

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

3208

8501034

Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium

1993

Roth, J.R.; Lawrence, J.G.; Rubenfield, M.; Kieffer-Higgins, S.; Church, G.M.

J. Bacteriol.

175

3303-3316

3209

7606163

Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes

1995

Roessner, C.A.; Spencer, J.B.; Ozaki, S.; Min, C.; Atshaves, B.P.; Nayar, P.; Anousis, N.; Stolowich, N.J.; Holderman, M.T.; Scott, A.I.

Protein Expr. Purif.

6

155-163

3210

1732194

The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8x as the substrate

1992

Thibaut, D.; Couder, M.; Famechon, A.; Debussche, L.; Cameron, B.; Crouzet, J.; Blanche, F.

J. Bacteriol.

174

1043-1049

3211

2211521

Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid

1990

Crouzet, J.; Cameron, B.; Cauchois, L.; Rigault, S.; Rouyez, M.C.; Blanche, F.; Thibaut, D.; Debussche, L.

J. Bacteriol.

172

5980-5990

3212

8550510

Salmonella typhimurium cobalamin (vitamin B12) biosynthetic genes: functional studies in S. typhimurium and Escherichia coli

1996

Raux, E.; Lanois, A.; Levillayer, F.; Warren, M.J.; Brody, E.; Rambach, A.; Thermes, C.

J. Bacteriol.

178

753-767

15273

1732195

Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product

1992

Blanche, F.; Famechon, A.; Thibaut, D.; Debussche, L.; Cameron, B.; Crouzet, J.

J. Bacteriol.

174

1050-1052

653928

11470433

Crystal structure of precorrin-8x methyl mutase

2001

Shipman, L.W.; Li, D.; Roessner, C.A.; Scott, A.I.; Sacchettini, J.C.

Structure

9

587-596

Links to other databases for precorrin-8X

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Show Links (1 entry)