Ligand 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate

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Basic Ligand Information

Molecular Structure
Picture of 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H19O27P7
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
UPHPWXPNZIOZJL-UOTPTPDRSA-N
Synonyms:
1-diphosinositol pentakisphosphate, 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate, 1D-myo-inositol 1-diphosphate pentakisphosphate, diphospho-myo-inositol pentakisphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP = 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
-
-
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
-
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.002
-
isoform PPIP5K2, in 20 mM HEPES-NaOH pH 7.2, 50 m MKCl, at 37C

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00011
-
isoform PPIP5K2, in 20 mM HEPES-NaOH pH 7.2, 50 m MKCl, at 37C

References & Links

Links to other databases for 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate

ChEBI
PubChem
ChEBI
PubChem