Ligand L-arogenate

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Basic Ligand Information

Molecular Structure
Picture of L-arogenate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H13NO5
L-arogenate
MIEILDYWGANZNH-DSQUFTABSA-N
Synonyms:
1-[(2S)-2-amino-2-carboxyethyl]-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid, 3-(1-Carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, arogenate


Show all pahtways known for Show all BRENDA pathways known for L-arogenate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arogenate + NAD+ = L-tyrosine + NADH + CO2
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
prephenate + L-aspartate = L-arogenate + oxaloacetate
show the reaction diagram
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prephenate + L-glutamate = L-arogenate + 2-oxoglutarate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arogenate + NAD+ = L-tyrosine + NADH + CO2
show the reaction diagram
-
L-arogenate + indolepyruvate = L-tryptophan + 3-(1-carboxy-4-hydroxycyclohexa-2,5-dienyl)2-oxopropanoate
show the reaction diagram
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L-arogenate + oxaloacetate = prephenate + L-aspartate
show the reaction diagram
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L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
prephenate + N-succinyl-L-2,6-diaminoheptanedioate = L-arogenate + N-succinyl-2-amino-6-oxoheptanedioate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
isozyme DS-Mn, competitive against D-erythrose 4-phosphate, non-competitive against phosphoenolpyruvate
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (17 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (49 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.45
-
pH 8.6, 37C, AAT I
0.8
-
pH 8.0

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.2
-
; pH 7.5, 22C; pH 7.5, 37C

References & Links

Links to other databases for L-arogenate

ChEBI
PubChem
ChEBI
PubChem