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Ligand 4-phenyl-1,3-thiazol-2-amine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.52

-

712694

-

1.13.11.52

0.1 mM, 13% inhibition

764286

-

1.13.11.52

2 entries

2.3.2.23

i.e. EM17, about 60% inhibition of FANCD2 ubiquination

759600

-

Enzyme Kinetic Parameters

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.13.11.52

1

-

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

712694

20055453

Rational design of indoleamine 2,3-dioxygenase inhibitors

2010

Roehrig, U.F.; Awad, L.; Grosdidier, A.; Larrieu, P.; Stroobant, V.; Colau, D.; Cerundolo, V.; Simpson, A.J.; Vogel, P.; Van den Eynde, B.J.; Zoete, V.; Michielin, O.

J. Med. Chem.

53

1172-1189

759600

28437106

Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening

2017

Morreale, F.E.; Bortoluzzi, A.; Chaugule, V.K.; Arkinson, C.; Walden, H.; Ciulli, A.

J. Med. Chem.

60

4093-4098

764286

28651980

Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase

2017

Balti, M.; Plas, A.; Meinguet, C.; Haufroid, M.; Themans, Q.; Efrit, M.L.; Wouters, J.; Lanners, S.

Bioorg. Med. Chem. Lett.

27

3607-3610

764286

28651980

Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase

2017

Balti, M.; Plas, A.; Meinguet, C.; Haufroid, M.; Themans, Q.; Efrit, M.L.; Wouters, J.; Lanners, S.

Bioorg. Med. Chem. Lett.

27

3607-3610

764286

2 entries

Links to other databases for 4-phenyl-1,3-thiazol-2-amine

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Show Links (1 entry)