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Ligand roseoflavin

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.343

8-amino-8-demethyl-D-riboflavin + S-adenosyl-L-methionine = roseoflavin + S-adenosyl-L-homocysteine

-

-

2.1.1.343

S-adenosyl-L-methionine + 8-amino-8-demethyl-D-riboflavin = S-adenosyl-L-homocysteine + roseoflavin

-

-

2.1.1.343

2 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.26

ATP + roseoflavin = ADP + roseoflavin 5'-phosphate

641240, 641244, 687408

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.343

8-amino-8-demethyl-D-riboflavin + S-adenosyl-L-methionine = roseoflavin + S-adenosyl-L-homocysteine

-

-

2.1.1.343

S-adenosyl-L-methionine + 8-amino-8-demethyl-D-riboflavin = S-adenosyl-L-homocysteine + roseoflavin

-

-

2.1.1.343

2 entries

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.343

competitive inhibition

742498

-

2.7.1.26

0.4 mM, 8% inhibition

641252

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.1.26

0.4

-

37°C

687408

2.7.1.26

0.5

-

37°C

687408

2.7.1.26

2 entries

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.26

0.03

-

37°C

687408

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.1.1.343

0.007

-

at pH 8.0 and 25°C

742498

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

641240

2163401

Purification, properties, and function of flavokinase from rat intestinal mucosa

1990

Kasai, S.; Nakano, H.; Maeda, K.; Matsui, K.

J. Biochem.

107

298-303

641244

227492

Preparation and properties of immobilized flavokinase

1979

Merrill, A.H.; McCormick, D.B.

Biotechnol. Bioeng.

21

1629-1638

641252

12693963

Main physicochemical features of monofunctional flavokinase from Bacillus subtilis

2003

Solovieva, I.M.; Tarasov, K.V.; Perumov, D.A.

Biochemistry

68

177-181

687408

18156273

The bifunctional flavokinase/flavin adenine dinucleotide synthetase from Streptomyces davawensis produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin

2008

Grill, S.; Busenbender, S.; Pfeiffer, M.; Koehler, U.; Mack, M.

J. Bacteriol.

190

1546-1553

742498

26913589

Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-D-riboflavin to the antibiotic roseoflavin

2016

Tongsook, C.; Uhl, M.; Jankowitsch, F.; Mack, M.; Gruber, K.; Macheroux, P.

FEBS J.

283

1531-1549

Links to other databases for roseoflavin

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Show Links (1 entry)