Ligand L-dehydroascorbic acid

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Basic Ligand Information

Molecular Structure
Picture of L-dehydroascorbic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6O6
L-dehydroascorbic acid
SBJKKFFYIZUCET-JLAZNSOCSA-N
Synonyms:
dehydro-ascorbate, dehydro-L-ascorbate, dehydroascorbate, dehydroascorbic acid, L-dehydro-ascorbate, L-dehydroascorbate, oxidized ascorbate


Show all pahtways known for Show all BRENDA pathways known for L-dehydroascorbic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
amylopectin + ascorbic acid + O2 = malto-aldonic acids + dehydroascorbate
show the reaction diagram
-
-
L-galactono-1,4-lactone + 4 ferricytochrome c = L-dehydroascorbate + 4 ferrocytochrome c + 4 H+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dehydro-L-ascorbate + NADPH = ? + NADP+
show the reaction diagram
-
(R)-dopaxanthin + dehydroascorbic acid + O2 = (R)-dopaxanthin quinone + L-ascorbic acid + H2O
show the reaction diagram
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(R)-dopaxanthin + dehydroascorbic acid + O2 = (R)-dopaxanthin quinone + L-ascorbic acid + H2O
show the reaction diagram
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dehydroascorbate + glutathione = ascorbate + glutathione disulfide
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (259 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ascorbate + H2O2 = dehydroascorbate + H2O
show the reaction diagram
-
-
2-oxoglutarate + O2 + ascorbate = succinate + dehydroascorbate + CO2 + H2O
show the reaction diagram
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2-oxoglutarate + O2 + ascorbate = succinate + CO2 + dehydroascorbate + H2O
show the reaction diagram
-
heme + 3 reduced ascorbate + 3 O2 = biliverdin + Fe2+ + CO + 3 oxidized ascorbate + 3 H2O
show the reaction diagram
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-
L-tyrosine + ascorbate + O2 = 3,4-dihydroxy-L-phenylalanine + dehydroascorbate + H2O
show the reaction diagram
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CMP-N-acetylneuraminate + ascorbic acid + O2 = CMP-N-glycoloylneuraminate + dehydroascorbate + H2O
show the reaction diagram
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amylopectin + ascorbic acid + O2 = malto-aldonic acids + dehydroascorbate
show the reaction diagram
-
-
L-galactono-1,4-lactone + 4 ferricytochrome c = L-dehydroascorbate + 4 ferrocytochrome c + 4 H+
show the reaction diagram
-
-
NO2- + reduced ascorbate = NO + oxidized ascorbate
show the reaction diagram
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nitric oxide + reduced ascorbate = nitrous oxide + oxidized ascorbate + H2O
show the reaction diagram
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-
ascorbate[side 1] + nitroblue tetrazolium[side 2] = dehydroascorbate + ?
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
partial activation
-
activates
-
preloading cells with dehydroascorbate greatly increases both ferric and cupric reductase activities of Dcytb
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at high concentrations
-
deactivates the enzyme activated by reduced thioredoxin f
-
weak inhibition
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inhibitory action of dehydroascorbic acid is revealed in the presence of Fe3+ ions and found to be primarily mediated by H2O2. The resulting inhibition by dehydroascorbic acid -Fe3+ consists of enzyme thiol oxidation and its effectiveness grew with increasing pH
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (22 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (46 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for L-dehydroascorbic acid

ChEBI
PubChem
ChEBI
PubChem