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0.164
-
pH 9.0, 30°C, EcDQD/SDH4a, quinate oxidation
0.3
-
purification step Q1 HiTrapQ, cofactor NAD+
0.3
-
purification step Q2 HiTrapQ, cofactor NADP+
0.5
-
purification step Q1 HiTrapQ, cofactor NADP+
0.8
-
purification step unbound to HiTrapQ, cofactor NADP+
1.9
-
purification step Q2 HiTrapQ, cofactor NAD+
10.9
-
purification step unbound to HiTrapQ, cofactor NAD+
0.783
-
pH 8.8, presence of 2 mM NAD+
2.351
-
mutant S275G/T318G, pH and temperature not specified in the publication
3.33
-
pH and temperature not specified in the publication, mutant T381G
4.075
-
pH and temperature not specified in the publication, mutant S338G/T381G
4.485
-
pH and temperature not specified in the publication, mutant T381S
5.135
-
pH and temperature not specified in the publication, mutant T381A
0.0054
-
mutant Y39F, 20°C, pH 9.0
0.0057
-
mutant S22A, 20°C, pH 9.0
0.0091
-
wild type enzyme, 20°C, pH 9.0
0.0136
-
mutant Q262A, 20°C, pH 9.0
0.0157
-
mutant S67A, 20°C, pH 9.0
0.041
-
pH 9, 20°C, cosubstrate NAD+
0.107
-
with NAD+, pH and temperature not specified in the publication
0.129
-
with NAD+, pH and temperature not specified in the publication
0.185
-
with NAD+, pH and temperature not specified in the publication
0.185
-
with NADP+, pH and temperature not specified in the publication
0.189
-
with NAD+, pH and temperature not specified in the publication
0.321
-
with NAD+, isozyme Poptr3, pH 8.5, 22°C
0.334
-
with NAD+, isozyme Poptr2, pH 8.5, 22°C
0.444
-
pH 7.0, temperature not specified in the publication, recombinant enzyme, with NAD+
0.555
-
pH 9, 20°C, cosubstrate NADP+
0.677
-
pH and temperature not specified in the publication, enzyme PintaQDH with NADP+
0.783
-
in the presence of 2 mM NAD+
1.56
-
pH 7.5, 30°C, with NAD+
1.88
-
pH 8.8, 25°C, with NAD+
2.38
-
pH 9.0-9.5, 30°C, with NAD+
2.541
-
with NADPH, pH 7.0, 30°C
2.95
-
pH 10, (-)-enantiomer, cosubstrate NAD+
3.4
3.6
pH 10, 20°C, cosubstrate NADP+, both forms of quinate (shikimate) dehydrogenase
20.52
-
mutant T106A, 20°C, pH 9.0
32.68
-
mutant K71A, 20°C, pH 9.0
0.2
-
pH 6.5, 25°C,with potassium ferricyanide or a combination of phenazine methosulfate and 2,6-dichlorophenol indophenol as electron acceptor
1
-
pH 8.0, temperature not specified in the publication, recombinant enzyme
0.00582
-
pH 8.0, 37°C, recombinant GST-tagged enzyme, with 4-coumaroyl-CoA
0.13
-
cosubstrate caffeoyl-CoA, pH 7.0, 25°C
0.444
-
cosubstrate caffeoyl-CoA, pH 7.0, 25°C
5.82
-
with 4-coumaroyl-CoA, pH 8.0, 37°C
0.077
-
cosubstrate 4-coumaroyl-CoA, pH not specified in the publication, 30°C
0.13
-
cosubstrate caffeoyl-CoA, pH 7.0, 25°C
0.203
-
cosubstrate caffeoyl-CoA, pH not specified in the publication, 30°C
0.43
-
with coumaroyl-CoA
0.444
-
cosubstrate caffeoyl-CoA, pH 7.0, 25°C
0.7635
-
pH 7.5, 30°C, recombinant enzyme
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Isolation and characterization of a chlorogenic acid esterase from Aspergillus niger
1980
Schöbel, B.
Z. Naturforsch. C
35
209-212
Further characterization of a chlorogenic acid hydrolase from Aspergillus niger
1980
Schöbel, B.; Pollmann, W.
Z. Naturforsch. C
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699-701
A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (-)t-3,t-4-dihydrocyclohexane-c-1carboxylate
1974
Whiting, G.C.; Coggins, R.A.
Biochem. J.
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Purification and characterization of quinate (shikimate) dehydrogenase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa
1978
Barea, J.L.; Giles, N.H.
Biochim. Biophys. Acta
524
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The identity of shikimate dehydrogenase and quinate dehydrogenase in Aspergillus niger
1972
Cain, R.B.
Biochem. J.
127
15P
-
Aromatic metabolism in plants III. Quinate dehydrogenase from mung bean cell suspension cultures
1966
Gamborg, O.L.
Biochim. Biophys. Acta
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The reversible association of quinate:NAD+ oxidoreductase from carrot cells with a putative regulatory subunit depends on light conditions
1983
Graziana, A.; Ranjeva, R.; Salimath, B.P.; Boudet, A.M.
FEBS Lett.
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Enzymes of aromatic biosynthesis C. quinic dehydrogenase from Aerobacter aerogenes
1955
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Utilization of quinate and p-hydroxybenzoate by actinomycetes: key enzymes and taxonomic relevance
1998
Grund, E.; Kutzner, H.J.
J. Basic Microbiol.
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Broad-specificity quinate (shikimate) dehydrogenase from Pinus taeda needles
2000
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Plant Physiol.
38
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-
Purification and characterization of the quinate: oxidoreductase from Phaseolus mungo sprouts
1993
Kang, X.; Scheibe, R.
Phytochemistry
33
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Bacterial NAD(P)-independent quinate dehydrogenase is a quinoprotein
1988
Van Kleef, M.A.G.; Duine, J.A.
Arch. Microbiol.
150
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-
Enzymatic synthesis of hydroxycinnamic acid esters of sugar acids and hydroaromatic acids by protein preparations from rye (Secale cereale) primary leaves
1987
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J. Plant Physiol.
131
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Enzymic synthesis of hydroxycinnamic acid esters of glucaric acid and hydroaromatic acids from the respective 1-O-hydroxycinnamoylglucoside and hydroxycinnamoyl-Coenzyme A thioester as acyldonors with a protein preparation from Cestrum elegans leaves
1987
Strack, D.; Gross, W.; Heilemann, J.; Keller, H.; Ohm, S.
Z. Naturforsch. C
43c
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-
Partial purification and characterization of hydroxycinnamoyl CoA:transferase from apple and date fruits
1992
Lotfy, L.; Fleuriet, A.; Macheix, J.J.
Phytochemistry
31
767-772
-
Hydroxycinnamoyl-CoA: transferases in higher plants. II. Characterization in Cichorium endivia and Raphanus sativus and comparison with other plants
1994
Lotfy, S.; Fleuriet, A.; Macheix, J.J.
Plant Physiol. Biochem.
32
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-
Inactivation and kinetic characterization of hydroxycinnamoyl-CoA:hydroaromatic acid O-hydroxycinnamoyltransferases from Cichorium endivia and Phoenix dactylifera
1995
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Plant Physiol. Biochem.
33
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Hydroxycinnamoyltransferases Involved in the accumulation of caffeic acid esters in gametophytes and sporophytes of Equisetum arvense
1996
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Plant Physiol.
111
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Purification, cloning, and properties of an acyltransferase controlling shikimate and quinate ester intermediates in phenylpropanoid metabolism
2003
Hoffmann, L.; Maury, S.; Martz, F.; Geoffroy, P.; Legrand, M.
J. Biol. Chem.
278
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Properties and activity changes of chlorogenic acid:glucaric acid caffeoyltransferase from tomato (Lycopersicon esculentum)
1990
Strack, D.; Gross, W.
Plant Physiol.
92
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-
The enzymic conversion of hydroxycinnamic acids to p-coumarylquinic and chlorogenic acids in tomato fruits
1976
Rhodes, M.J.C.; Wooltorton, L.S.C.
Phytochemistry
15
947-951
-
Purification and properties of hydroxycinnamoyl CoA quinate hydroxycinnamoyl transferase from potatoes
1979
Rhodes, M.J.C.; Wooltorton, L.S.C.; Lourencq, E.J.
Phytochemistry
18
1125-1129
Enzymic synthesis of caffeoylglucaric acid from chlorogenic acid and glucaric acid by a protein preparation from tomato cotyledons
1987
Strack, D.; Gross, W.; Wray, V.; Grotjahn, L.
Plant Physiol.
83
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Metabolism of phenolic compounds during loquat fruit development
2001
Ding, C.K.; Chachin, K.; Ueda, Y.; Imahori, Y.; Wang, C.Y.
J. Agric. Food Chem.
49
2883-2888
Structures of shikimate dehydrogenase AroE and its paralog YdiB. A common structural framework for different activitie
2003
Michel, G.; Roszak, A.W.; Sauvé, V.; Maclean, J.; Matte, A.; Coggins, J.R.; Cygler, M.; Lapthorn, A.J.
J. Biol. Chem.
278
19463-19472
The 2.3-Ã
crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase
2003
Benach, J.; Lee, I.; Edstrom, W.; Kuzin, A.P.; Chiang, Y.; Acton, T.B.; Montelione, G.T.; Hunt, J.F.
J. Biol. Chem.
278
19176-19182
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1
2003
Smith, M.A.; Weaver, V.B.; Young, D.M.; Ornston, L.N.
Appl. Environ. Microbiol.
69
524-532
Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid
2001
Couteau, D.; McCartney, A.L.; Gibson, G.R.; Williamson, G.; Faulds, C.B.
J. Appl. Microbiol.
90
873-881
-
Hydroaromatic metabolism in Rhodococcus rhodochrous: purification and characterization of its NAD-dependent quinate dehydrogenase
1990
Bruce, N.C.; Cain, R.B.
Arch. Microbiol.
154
179-186
-
The role of quinate dehydrogenase in quinic acid metabolism in coniferous plants
1986
Osipov, V.I.; Shein, I.V.
Biokhimiya
51
230-236
Purification and characterization of membrane-bound quinoprotein quinate dehydrogenase
2003
Adachi, O.; Yoshihara, N.; Tanasupawat, S.; Toyama, H.; Matsushita, K.
Biosci. Biotechnol. Biochem.
67
2115-2123
3-Dehydroquinate production by oxidative fermentation and further conversion of 3-dehydroquinate to the intermediates in the shikimate pathway
2003
Adachi, O.; Tanasupawat, S.; Yoshihara, N.; Toyama, H.; Matsushita, K.
Biosci. Biotechnol. Biochem.
67
2124-2131
Site-directed mutagenesis of the active site region in the quinate/shikimate 5-dehydrogenase YdiB of Escherichia coli
2005
Lindner, H.A.; Nadeau, G.; Matte, A.; Michel, G.; Menard, R.; Cygler, M.
J. Biol. Chem.
280
7162-7169
-
Broad-specificity quinate (shikimate) dehydrogenase from Pinus taeda needles
2000
Ossipov, V.; Bonner, C.; Ossipova, S.; Jensen, R.
Plant Physiol. Biochem.
38
923-928
Engineering plants with increased levels of the antioxidant chlorogenic acid
2004
Niggeweg, R.; Michael, A.J.; Martin, C.
Nat. Biotechnol.
22
746-754
Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay
2005
Funke, I.; Melzig, M.F.
Pharmazie
60
796-797
Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori
2006
Han, C.; Wang, L.; Yu, K.; Chen, L.; Hu, L.; Chen, K.; Jiang, H.; Shen, X.
FEBS J.
273
4682-4692
Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae
2005
Singh, S.; Korolev, S.; Koroleva, O.; Zarembinski, T.; Collart, F.; Joachimiak, A.; Christendat, D.
J. Biol. Chem.
280
17101-17108
High shikimate production from quinate with two enzymatic systems of acetic acid bacteria
2006
Adachi, O.; Ano, Y.; Toyama, H.; Matsushita, K.
Biosci. Biotechnol. Biochem.
70
2579-2582
Isolation and functional characterization of a cDNA coding a hydroxycinnamoyltransferase involved in phenylpropanoid biosynthesis in Cynara cardunculus L
2007
Comino, C.; Lanteri, S.; Portis, E.; Acquadro, A.; Romani, A.; Hehn, A.; Larbat, R.; Bourgaud, F.
BMC Plant Biol.
7
14
Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases
2006
Ramirez-Ahumada, M.d.e.l.C.; Timmermann, B.N.; Gang, D.R.
Phytochemistry
67
2017-2029
Functional analysis of the essential bifunctional tobacco enzyme 3-dehydroquinate dehydratase/shikimate dehydrogenase in transgenic tobacco plants
2007
Ding, L.; Hofius, D.; Hajirezaei, M.R.; Fernie, A.R.; Boernke, F.; Sonnewald, U.
J. Exp. Bot.
58
2053-2067
1.6 A structure of an NAD(+)-dependent quinate dehydrogenase from Corynebacterium glutamicum
2008
Schoepe, J.; Niefind, K.; Schomburg, D.
Acta Crystallogr. Sect. D
64
803-809
Metabolism of shikimate and quinate by Aspergillus niger and its regulation
1972
Cain, R.B.
Biochem. J.
127
15P-16P
A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass
2008
Singh, S.; Stavrinides, J.; Christendat, D.; Guttman, D.S.
Mol. Biol. Evol.
25
2221-2232
Changes in quinic acid metabolism during fruit development in three kiwifruit species
2009
Marsh, K.; Boldingh, H.; Shilton, R.; Laing, W.
Funct. Plant Biol.
36
463-470
The isolation and mapping of a novel hydroxycinnamoyltransferase in the globe artichoke chlorogenic acid pathway
2009
Comino, C.; Hehn, A.; Moglia, A.; Menin, B.; Bourgaud, F.; Lanteri, S.; Portis, E.
BMC Plant Biol.
9
30
Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II
2009
Narita, Y.; Inouye, K.
J. Agric. Food Chem.
57
9218-9225
A novel red clover hydroxycinnamoyl transferase has enzymatic activities consistent with a role in phaselic acid biosynthesis
2009
Sullivan, M.
Plant Physiol.
150
1866-1879
Molecular characterization and heterologous expression of quinate dehydrogenase gene from Gluconobacter oxydans IFO3244
2010
Vangnai, A.S.; Promden, W.; De-Eknamkul, W.; Matsushita, K.; Toyama, H.
Biochemistry (Moscow)
75
452-459
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies
2009
Bora-Tatar, G.; Dayangac-Erden, D.; Demir, A.S.; Dalkara, S.; Yelekci, K.; Erdem-Yurter, H.
Bioorg. Med. Chem.
17
5219-5228
Purification, crystallization and preliminary X-ray diffraction analysis of a hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase (HCT) from Coffea canephora involved in chlorogenic acid biosynthesis
2012
Lallemand, L.A.; McCarthy, J.G.; McSweeney, S.; McCarthy, A.A.
Acta Crystallogr. Sect. F
68
824-828
-
Characterization of hydroxycinnamoyl-coenzyme A shikimate hydroxycinnamoyltransferase from Populus euramericana
2011
Kim, B.; Kim, I.; Ahn, J.
J. Korean Soc. Appl. Biol. Chem.
54
817-821
Cloning and characterization of a cDNA coding a hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase involved in chlorogenic acid biosynthesis in Lonicera japonica
2010
Peng, X.; Li, W.; Wang, W.; Bai, G.
Planta Med.
76
1921-1926
Distinct substrate specificities and unusual substrate flexibilities of two hydroxycinnamoyltransferases, rosmarinic acid synthase and hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl-transferase, from Coleus blumei Benth.
2011
Sander, M.; Petersen, M.
Planta
233
1157-1171
Characterization of shikimate dehydrogenase homologues of Corynebacterium glutamicum
2013
Kubota, T.; Tanaka, Y.; Hiraga, K.; Inui, M.; Yukawa, H.
Appl. Microbiol. Biotechnol.
97
8139-8149
Enzyme-substrate complexes of the quinate/shikimate dehydrogenase from Corynebacterium glutamicum enable new insights in substrate and cofactor binding, specificity, and discrimination
2013
Höppner, A.; Schomburg, D.; Niefind, K.
Biol. Chem.
394
1505-1516
Elucidation of the structure and reaction mechanism of sorghum hydroxycinnamoyltransferase and its structural relationship to other coenzyme a-dependent transferases and synthases
2013
Walker, A.M.; Hayes, R.P.; Youn, B.; Vermerris, W.; Sattler, S.E.; Kang, C.
Plant Physiol.
162
640-651
The shikimate dehydrogenase family: functional diversity within a conserved structural and mechanistic framework
2015
Peek, J.; Christendat, D.
Arch. Biochem. Biophys.
566
85-99
Insights into the function of RifI2: structural and biochemical investigation of a new shikimate dehydrogenase family protein
2013
Peek, J.; Garcia, C.; Lee, J.; Christendat, D.
Biochim. Biophys. Acta
1834
516-523
Molecular characterization of quinate and shikimate metabolism in Populus trichocarpa
2014
Guo, J.; Carrington, Y.; Alber, A.; Ehlting, J.
J. Biol. Chem.
289
23846-23858
Synthesis of the inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors
2015
Cholewinski, G.; Iwaszkiewicz-Grzes, D.; Prejs, M.; Glowacka, A.; Dzierzbicka, K.
J. Enzyme Inhib. Med. Chem.
30
550-563
The role of the ydiB gene, which encodes quinate/shikimate dehydrogenase, in the production of quinic, dehydroshikimic and shikimic acids in a PTS- strain of Escherichia coli
2016
Garcia, S.; Flores, N.; De Anda, R.; Hernandez, G.; Gosset, G.; Bolivar, F.; Escalante, A.
J. Mol. Microbiol. Biotechnol.
27
11-21
-
Isolation and functional characterization of a Lonicera japonica hydroxycinnamoyl transferase involved in chlorogenic acid synthesis
2017
Pu, G.; Zhou, B.; Xiang, F.
Biologia (Poland)
72
608-618
In vitro evaluation of hydroxycinnamoyl CoA quinate hydroxycinnamoyl transferase expression and regulation in Taraxacum antungense in relation to 5-caffeoylquinic acid production
2019
Liu, Q.; Yao, L.; Xu, Y.; Cheng, H.; Wang, W.; Liu, Z.; Liu, J.; Cui, X.; Zhou, Y.; Ning, W.
Phytochemistry
162
148-156
Isolation and functional characterization of hydroxycinnamoyltransferases from the liverworts Plagiochasma appendiculatum and Marchantia paleacea
2018
Wu, Y.F.; Zhao, Y.; Liu, X.Y.; Gao, S.; Cheng, A.X.; Lou, H.X.
Plant Physiol. Biochem.
129
400-410
The role of the ydiB gene, which encodes quinate/shikimate dehydrogenase, in the production of quinic, dehydroshikimic and shikimic acids in a PTS-strain of Escherichia coli
2017
Garcia, S.; Flores, N.; De Anda, R.; Hernandez, G.; Gosset, G.; Bolivar, F.; Escalante, A.
J. Mol. Microbiol. Biotechnol.
27
11-21
Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases
2018
Gritsunov, A.; Peek, J.; Diaz Caballero, J.; Guttman, D.; Christendat, D.
Plant J.
95
812-822
Evolution of a secondary metabolic pathway from primary metabolism shikimate and quinate biosynthesis in plants
2018
Carrington, Y.; Guo, J.; Le, C.H.; Fillo, A.; Kwon, J.; Tran, L.T.; Ehlting, J.
Plant J.
95
823-833
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis
2020
Tahara, K.; Nishiguchi, M.; Funke, E.; Miyazawa, S.I.; Miyama, T.; Milkowski, C.
Planta
253
3
Improved heterologous expression of the membrane-bound quinoprotein quinate dehydrogenase from Gluconobacter oxydans
2018
Yakushi, T.; Komatsu, K.; Matsutani, M.; Kataoka, N.; Vangnai, A.S.; Toyama, H.; Adachi, O.; Matsushita, K.
Protein Expr. Purif.
145
100-107
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