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Ligand 2-aminomuconate

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for 2-aminomuconate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.99.11

2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3

736354

-

3.5.99.5

2-aminomuconate + H2O = ?

172187, 172186

-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.32

2-aminomuconate 6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH + 2 H+

-

-

1.2.1.32

2-aminomuconate 6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH + H+

-

-

1.2.1.32

2-aminomuconate-6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH

4568, 172187, 390254

-

1.2.1.32

3 entries

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.99.11

2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3

736354

-

3.5.99.11

2-aminomuconate + H2O = 4-oxalocrotonate + NH3

172186

-

3.5.99.5

2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3

777427

-

3.5.99.5

2-aminomuconate + H2O = 4-oxalocrotonate + NH3

172186, 172187, 669076, 669112, 667336

-

3.5.99.5

2-aminomuconate + H2O = ?

172187, 172186

-

3.5.99.11

2 entries

3.5.99.5

3 entries

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.32

2-aminomuconate 6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH + 2 H+

-

-

1.2.1.32

2-aminomuconate 6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH + H+

-

-

1.2.1.32

2-aminomuconate-6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH

4568, 390244, 172187, 390254

-

1.2.1.32

2-aminomuconic acid semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH + H+

-

-

1.2.1.32

4 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.5.99.11

208

-

pH 6.6, 25°C

172186

3.5.99.5

208

-

-

172186

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.99.11

0.0039

-

pH and temperature not specified in the publication

736354

3.5.99.11

0.067

-

pH 6.6, 25°C

172186

3.5.99.11

2 entries

3.5.99.5

0.067

-

-

172186

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4568

14275130

Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues II. Enzymic formation of alpha-aminomuconic acid from 3-hydroxyanthranilic acid

1965

Ichiyama, A.; Nakamura, S.; Kawai, H.; Honjo, T.; Nishizuka, Y.; Hayaishi, O.; Senoh, S.

J. Biol. Chem.

240

740-749

172186

9573204

A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45

1998

He, Z.; Spain, J.C.

J. Bacteriol.

180

2502-2506

172187

9471964

Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde

1997

He, Z.; Spain, J.C.

Appl. Environ. Microbiol.

63

4839-4843

390244

-

alpha-Aminomuconic epsilon-semialdehyde dehydrogenase (cat liver)

1970

Nishizuka, Y.; Ichiyama, A.; Hayaishi, O.

Methods Enzymol.

17A

476-483

390254

9721300

Purification, characterization, and sequence analysis of 2-aminomuconic 6-semialdehyde dehydrogenase from Pseudomonas pseudoalcaligenes JS45

1998

He, Z.; Davis, J.K.; Spain, J.C.

J. Bacteriol.

180

4591-4595

667336

11081795

Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3

2000

Takenaka, S.; Murakami, S.; Kim, Y.J.; Aoki, K.

Arch. Microbiol.

174

265-272

669076

10633088

Identification and characterization of the nitrobenzene catabolic plasmids pNB1 and pNB2 in Pseudomonas putida HS12

2000

Park, H.S.; Kim, H.S.

J. Bacteriol.

182

573-580

669112

16267312

Tryptophan catabolism: Identification and characterization of a new degradative pathway

2005

Colabroy, K.L.; Begley, T.P.

J. Bacteriol.

187

7866-7869

736354

17259310

A novel deaminase involved in chloronitrobenzene and nitrobenzene degradation with Comamonas sp. strain CNB-1

2007

Liu, L.; Wu, J.F.; Ma, Y.F.; Wang, S.Y.; Zhao, G.P.; Liu, S.J.

J. Bacteriol.

189

2677-2682

777427

31555255

A unique homo-hexameric structure of 2-aminomuconate deaminase in the bacterium Pseudomonas species AP-3

2019

Chen, Y.; Chen, Y.; Jiang, H.; Lu, D.; Hu, T.; Bi, G.; Ran, Y.; Yu, B.; Dong, H.; Su, D.

Front. Microbiol.

10

2079

Links to other databases for 2-aminomuconate

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Show Links (1 entry)