Ligand D-Fructose 1-phosphate

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Basic Ligand Information

Molecular Structure
Picture of D-Fructose 1-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O9P
D-Fructose 1-phosphate
RHKKZBWRNHGJEZ-ARQDHWQXSA-N
Synonyms:
D-fructose-1-phosphate, D-fructose 1 -phosphate, fructose-1-phosphate, fructose 1-phosphate


Show all pahtways known for Show all BRENDA pathways known for D-Fructose 1-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methylglyoxal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
show the reaction diagram
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ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate
show the reaction diagram
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ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate
show the reaction diagram
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D-fructose 1-phosphate + H2O = D-fructose + phosphate
show the reaction diagram
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D-fructose 1-phosphate + H2O = D-fructose + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + D-fructose = ADP + D-fructose 1-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-fructose 1-phosphate + NADH = ?
show the reaction diagram
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methylglyoxal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
show the reaction diagram
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D-glucose + D-fructose 1-phosphate = D-glucose 6-phosphate + D-fructose
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GTP + D-fructose 1-phosphate = diphosphate + GDP-fructose
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D-fructose 1-phosphate + H2O = D-fructose + phosphate
show the reaction diagram
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Fructose 1-phosphate + H2O = Fructose + phosphate
show the reaction diagram
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D-fructose 1-phosphate + H2O = D-fructose + phosphate
show the reaction diagram
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D-fructose 1-phosphate + H2O = D-fructose + phosphate
show the reaction diagram
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Fructose 1-phosphate + H2O = Fructose + phosphate
show the reaction diagram
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D-fructose-1-phosphate + H2O = D-fructose + phosphate
show the reaction diagram
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Fructose 1-phosphate + H2O = Fructose + phosphate
show the reaction diagram
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D-fructose 1-phosphate + H2O = D-fructose + phosphate
show the reaction diagram
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D-Fructose 1-phosphate = Glycerone phosphate + D-glyceraldehyde
show the reaction diagram
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D-Fructose 1-phosphate = ?
show the reaction diagram
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D-Fructose 1-phosphate = ?
show the reaction diagram
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D-fructose-1-phosphate = D-fructose-6-phosphate
show the reaction diagram
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Fructose 1-phosphate + D-glucose = D-glucose 6-phosphate + fructose
show the reaction diagram
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D-fructose-1-phosphate = D-fructose-6-phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-keto-D-fructose 1-phosphate + NADPH + H+ = D-fructose 1-phosphate + NADP+
show the reaction diagram
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ATP + fructose = ADP + fructose 1-phosphate
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ATP + D-fructose = ADP + D-fructose 1-phosphate
show the reaction diagram
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ATP + D-fructose = ADP + D-fructose 1-phosphate
show the reaction diagram
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D-fructose + acetyl phosphate = D-fructose 1-phosphate + D-fructose 6-phosphate + acetate
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phosphoramidate + fructose = fructose 1-phosphate + NH3
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phosphoenolpyruvate + fructose = pyruvate + fructose 1-phosphate
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D-fructose-1,6-bisphosphate + H2O = D-fructose-1-phosphate + phosphate
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D-fructose 1,6-bisphosphate + H2O = D-fructose 1-phosphate + phosphate
show the reaction diagram
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Glycerone phosphate + D-glyceraldehyde = Fructose 1-phosphate
show the reaction diagram
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D-glucose 1-phosphate + D-fructose 1,6-diphosphate = D-glucose 1,6-diphosphate + D-fructose 1-phosphate + D-fructose 6-phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight activation
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activation, less effective than D-fructose 6-phosphate
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2 mM, 78% activation
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Inhibitor in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight inhibition
-
at higher concentrations
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competitive against D-fructose, noncompetitive to MgATP2-
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allosteric inhibitor with a 40% reduction in the Vmax
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62% residual activity at 5 mM
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10 mM, 26% inhibition
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competitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (38 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.03
-
pH 7.0, 37C
1.6
-
pH 5.5, 37C

KM Value (86 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.823
-
pH 7.0, 37C
1
-
pH 7.7
1.9
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pH 5.5, 37C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4
-
50C, pH 7.5, D-fructose 6-phosphate as substrate

References & Links

Links to other databases for D-Fructose 1-phosphate

ChEBI
PubChem
ChEBI
PubChem