Ligand sodium borohydride

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Basic Ligand Information

Molecular Structure
Picture of sodium borohydride (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H4BNa
sodium borohydride
YOQDYZUWIQVZSF-UHFFFAOYSA-N
Synonyms:
NaBH4, Sodium boranate, sodium borhydride, sodium borohydrate

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-
activates at above 12 mM
-
activates
-

Inhibitor in Enzyme-catalyzed Reactions (103 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
rapid inactivation in the presence of thiamine diphosphate, may reduce thiamine diphosphate to produce a reversible inhibitor
-
59% inhibition at 1 mM
-
partially inactivates
-
5 mM: complete inhibition
-
pH 8.0
-
decreases cysteine desulfurase and biotin synthase activity
-
rapid and irreversible inactivation
-
only in presence of a CoA substrate
-
after incubation with 20 mM NaBH4 at pH 7.0 in the presence of 0.2 mM (R)-2-hydroxyisocaproyl-CoA and removal of the small molecules by gel filtration, the transferase sample shows 88% inactivation, while no inactivation is observed under the same conditions in the absence of (R)-2-hydroxyisocaproyl-CoA
-
5 mM
-
irreversible
-
in presence of an amine
-
inactivation
-
69% inactivation in the presence of NaBH% and pyruvate, complete inactivation when the reaction time is increased to 20 min
-
; extensive loss of activity after incubation of enzyme with NaBH4 in presence of pyruvate or glyoxylate
-
95% inhibition only when 5-dehydro-4-deoxy-D-glucarate is added
-
inhibition is partly reversed by pyridoxal-5'-phosphate or dehydroascorbic acid
-
complete inhibition at 1 mM
-
reductive inhibition
-
inhibition in absence of substrate, increases activity in presence of substrate and GSH
-
partial inactivation in presence of NAD+. No inactivation in absence of NAD+
-

Enzyme Kinetic Parameters

References & Links

Links to other databases for sodium borohydride

ChEBI
PubChem
ChEBI
PubChem