Ligand 8-oxo-dGMP
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Basic Ligand Information
C10H14N5O8P
8-oxo-dGMP
AQIVLFLYHYFRKU-UOWFLXDJSA-N
Related pathways
MetaCyc
8-oxo-(d)GTP detoxification I, 8-oxo-(d)GTP detoxification II
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (4 results)
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8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate
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8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
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8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
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8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate
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Product in Enzyme-catalyzed Reactions (9 results)
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8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate
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8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
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8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 phosphate
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8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate
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8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
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8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate
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8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
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8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate
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8-oxo-dGTP + H2O = 8-oxo-dGMP + 2 phosphate
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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the ADP-ribose cleavage is competitively inhibited by 8-oxo-dGMP (89% relative cleavage efficiency at 0.01 mM)
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noncompetitive inhibitor of dGTP hydrolysis
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Enzyme Kinetic Parameters
Ki Value (4 results)
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0.000049
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pH 7.5, 23°C, Mg2+-activated, Ki(slope)
0.000173
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pH 7.5, 23°C, Mn2+-activated, Ki(slope)
0.000593
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pH 7.5, 23°C, Mn2+-activated, Ki(intercept)
0.00162
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pH 7.5, 23°C, Mg2+-activated, Ki(intercept)
References & Links
Literature References (2)
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Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase
2002
Saraswat, V.; Massiah, M.A.; Lopez, G.; Amzel, L.M.; Mildvan, A.S.
Biochemistry
41
15566-15577
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein
2011
Ito, R.; Sekiguchi, M.; Setoyama, D.; Nakatsu, Y.; Yamagata, Y.; Hayakawa, H.
J. Biochem.
149
731-738
Links to other databases for 8-oxo-dGMP
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