Any feedback?
Please rate this page
(ligand.php)
(0/150)

BRENDA support

Ligand taurine

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of taurine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H7NO3S
taurine
XOAAWQZATWQOTB-UHFFFAOYSA-N
Synonyms:
2-Aminoethane sulfonate, 2-aminoethanesulfonic acid, ethylamine-2-sulfonic acid, taurin, taurine[side 2]


Show all pahtways known for Show all BRENDA pathways known for taurine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Cl- + H2O2 + H+ + taurine + H+ = taurine monochloroamine + 2 H2O
show the reaction diagram
-
taurine + NADH + H+ + pyruvate = tauropine + NAD+ + H2O
show the reaction diagram
-
choloyl-CoA + taurine = CoA + taurocholate
show the reaction diagram
-
taurine + 2-oxoglutarate = 2-sulfoacetaldehyde + L-glutamate
show the reaction diagram
-
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-cysteate = taurine + CO2
show the reaction diagram
-
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (73 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
taurine + Br- + peracetic acid = bromotaurine + ?
show the reaction diagram
-
taurine + Cl- + H2O2 = taurine chloramine + HOCl + H2O
show the reaction diagram
-
arginine + taurine = 2-guanidinoethanesulfonic acid + ornithine
show the reaction diagram
-
acetyl-CoA + 2-aminoethanesulfonic acid = CoA + ?
show the reaction diagram
-
taurine + 2-oxoglutarate = ? + L-glutamate
show the reaction diagram
-
pyruvate + taurine = L-alanine + 2-oxoethanesulfonic acid
show the reaction diagram
-
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (53 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-taurine + H2O = taurine + acetate
show the reaction diagram
-
N-oleoyl taurine + H2O = oleic acid + taurine
show the reaction diagram
-
N-oleoyltaurine + H2O = taurine + oleic acid
show the reaction diagram
-
taurocyamine + H2O = taurine + urea
show the reaction diagram
-
L-cysteate = taurine + CO2
show the reaction diagram
-
Cysteic acid = 2-Aminoethane sulfonate + CO2
show the reaction diagram
-
ATP + H2O + taurine-[sulfonate-binding protein][side 1] = ADP + phosphate + taurine[side 2] + [sulfonate-binding protein][side 1]
show the reaction diagram
-
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates the enzyme, and acts as antagonist and reduces the hypochlorous acid toxicity
-
0.5 M taurine activates the enzyme 3fold in the absence of monovalent cations
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 19% inhibition at 0.1 mM
-
i.e. taurine, competitive
-
slight inhibition
-
uncompetitive inhibition of glycocholic acid hydrolysis

3D Structure of Enzyme-Ligand-Complex (PDB) (46 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
14.8
-
pH 7.5, 25°C
0.51
-
cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication
3.7
-
pH 7.2, 37°C, recombinant enzyme

KM Value (33 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
392
-
alpha-transamidinase
18.9
-
pH 7.5, 25°C
12
-
cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
68
-
pH 8.6, 25°C
2.5
-
pH 8.0, 50°C

References & Links

Links to other databases for taurine

ChEBI
PubChem
ChEBI
PubChem