Ligand myo-inositol hexakisphosphate

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Basic Ligand Information

Molecular Structure
Picture of myo-inositol hexakisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H18O24P6
myo-inositol hexakisphosphate
IMQLKJBTEOYOSI-GPIVLXJGSA-N
Synonyms:
1,2,3,4,5,6-cyclohexanehexolphosphoric acid, 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 1D-myo-inositol hexakisphosphate, D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, inositol-hexakisphosphate, Inositol hexakisphosphate, Inositol hexaphosphate, inositolhexaphosphate, myo-inositol-1,2,3,4,5,6-hexakissulfate, myo-inositol hexakishosphate, phytate, phytic acid


Show all pahtways known for Show all BRENDA pathways known for myo-inositol hexakisphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphosphoinositol pentakisphosphate
show the reaction diagram
-
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
myo-inositol hexakisphosphate + H2O = ? + phosphate
show the reaction diagram
-
inositol hexakisphosphate + H2O = inositol pentakisphosphate + phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol 1,2,3,4,6-pentakisphosphate = ADP + inositol hexakisphosphate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (49 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphosphoinositol pentakisphosphate
show the reaction diagram
-
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + H2O = D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate
show the reaction diagram
-
inositol hexakisphosphate + H2O = ?
show the reaction diagram
-
phytic acid + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (41 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADP + 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate = ATP + 1D-myo-inositol hexakisphosphate
show the reaction diagram
-
5-diphosphoinositol 1,2,3,4,6-pentakisphosphate + H2O = myo-inositol hexakisphosphate + phosphate
show the reaction diagram
-
-

Enzyme Cofactor/Cosubstrate (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at pH 9.9
-
0.1 mM, almost complete inhibition
-
weak, IC50: 3.6 mM with rhodopsin as substrate
-
IC50 for inositol hexakisphosphate kinase activity is 0.0008 mM, IC50 for ATP synthase activity is 0.0018 mM
strong inhibition
-
competitive
-
50% inhibition at 0.05 mM
-
95.6% inhibition at 10 mM
-
i.e. inositol hexaphosphate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (123 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (168 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.03
-
isoform PPIP5K2, in 20 mM HEPES-NaOH pH 7.2, 50 mM KCl, at 37C
124
-
in 2 mM phytate in 50 mM sodium acetate pH 4.0, at 50C

KM Value (340 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.574
-
in 2 mM phytate in 50 mM sodium acetate pH 4.0, at 50C

Ki Value (10 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.62
-
pH 5.8, 25C
18431
2.3
-
free, not complexed with Ca2+, competitive inhibitor
18748

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0018
-
IC50 for inositol hexakisphosphate kinase activity is 0.0008 mM, IC50 for ATP synthase activity is 0.0018 mM

References & Links

Links to other databases for myo-inositol hexakisphosphate

ChEBI
PubChem
ChEBI
PubChem