Ligand choloyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of choloyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C45H74N7O20P3S
choloyl-CoA
ZKWNOTQHFKYUNU-JGCIYWTLSA-N
Synonyms:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA, 7alpha-hydroxy-3-oxochol-24-oyl-CoA, cholyl-CoA


Show all pahtways known for Show all BRENDA pathways known for choloyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
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3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA
show the reaction diagram
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choloyl-CoA + H2O = cholate + CoA
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
choloyl-CoA + NAD(P)+ = 3-oxocholoyl-CoA + NAD(P)H + H+
show the reaction diagram
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choloyl-CoA + NAD+ = 3-oxocholoyl-CoA + NADH + H+
show the reaction diagram
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7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
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3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA
show the reaction diagram
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choloyl-CoA + H2O = CoA + choloate
show the reaction diagram
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choloyl-CoA + H2O = cholate + CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
uncompetitive versus CoA
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0146
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pH 7.4

References & Links

Links to other databases for choloyl-CoA

ChEBI
PubChem
ChEBI
PubChem