Ligand dTDP

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Basic Ligand Information

Molecular Structure
Picture of dTDP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H16N2O11P2
dTDP
UJLXYODCHAELLY-XLPZGREQSA-N
Synonyms:
2'-dTDP, 5'-dTDP, D-2'-dTDP, D-dTDP, TDP, Thymidine 5'-diphosphate, thymidine diphosphate
Pathway Source
Pathways
MetaCyc
acetan biosynthesis, aclacinomycin biosynthesis, daunorubicin biosynthesis, dimycocerosyl triglycosyl phenolphthiocerol biosynthesis, elloramycin biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for dTDP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
TDP + phosphoenolpyruvate = TTP + pyruvate
show the reaction diagram
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TDP + (phosphate)n+1 = TTP + (phosphate)n
show the reaction diagram
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ADP + TDP = AMP + TTP
show the reaction diagram
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TDP + H2O = TMP + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (64 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B = dTDP + erythromycin D
show the reaction diagram
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dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
show the reaction diagram
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dTDP-beta-L-noviose + novobiocic acid = dTDP + demethyldecarbamoyl novobiocin
show the reaction diagram
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tylactone + dTDP-alpha-D-mycaminose = dTDP + 5-O-beta-D-mycaminosyltylactone
show the reaction diagram
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5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin
show the reaction diagram
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dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin
show the reaction diagram
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dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin
show the reaction diagram
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dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = dTDP + 4-acetamido-4,6-dideoxy-alpha-D-galactosyl-(1->4)-N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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dTDP-2-deoxy-beta-L-fucose + aclacinomycin T = dTDP + aclacinomycin S
show the reaction diagram
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dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
show the reaction diagram
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dTDP-2-deoxy-beta-L-fucose + 4-O-(alpha-L-rhodosaminyl)aklavinone = dTDP + 4-O-[(4-O-2-deoxy-alpha-L-fucosyl)-alpha-L-rhodosaminyl]aklavinone
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ATP + thymidine 5'-phosphate = ADP + thymidine diphosphate
show the reaction diagram
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ATP + dTMP = ADP + dTDP
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ATP + TMP = ADP + TDP
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TTP + H2O = TDP + phosphate
show the reaction diagram
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dTTP + H2O = dTDP + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (51 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
TDP + D-glucose = TMP + D-glucose 6-phosphate
show the reaction diagram
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TDP + phosphoramide = TTP + NH3
show the reaction diagram
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TDP + (phosphate)n+1 = TTP + (phosphate)n
show the reaction diagram
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ADP + TDP = AMP + TTP
show the reaction diagram
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TDP + H2O = TMP + phosphate
show the reaction diagram
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TDP + H2O = ?
show the reaction diagram
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TDP + H2O = TMP + phosphate
show the reaction diagram
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adenosine 5'-phosphoimidazolide + TDP = imidazole + A(5')p3(5')T
show the reaction diagram
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TDP + H2O = TMP + phosphate
show the reaction diagram
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TDP + H2O = ?
show the reaction diagram
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dTDP + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (343 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dTDP-glucose + (1,4-alpha-D-glucosyl)n = dTDP + (1,4-alpha-D-glucosyl)n+1
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dTDP-alpha-D-glucose + sinapic acid = dTDP + 1-O-sinapoyl-beta-D-glucose
show the reaction diagram
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TDP-glucose + D-fructose = TDP + sucrose
show the reaction diagram
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TDP-glucose + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R = TDP + ?
show the reaction diagram
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TDP-glucose + hydroquinone = TDP + hydroquinone-O-beta-D-glucopyranoside
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TDP-glucose + a flavonol 3-O-beta-D-glucoside = TDP + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucoside
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TDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucoside = TDP + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucosyl-(1-2)-beta-D-glucoside
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dTDP-glucose + (1,4-alpha-D-glucosyl)n = dTDP + (1,4-alpha-D-glucosyl)n+1
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TDP-glucose + 3-phospho-D-glycerate = TDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
show the reaction diagram
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dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
show the reaction diagram
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5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin
show the reaction diagram
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dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin
show the reaction diagram
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dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = dTDP + 4-acetamido-4,6-dideoxy-alpha-D-galactosyl-(1->4)-N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
show the reaction diagram
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TDP-alpha-D-glucose + validoxylamine A = TDP + validamycin A
show the reaction diagram
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dTDP-glucose + poly(glycerophosphate) = dTDP + alpha-D-glucosyl-poly(glycerol phosphate)
show the reaction diagram
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TDP-glucose + D-galactosylhydroxylysine = TDP + 1,2-D-glucosyl-D-galactosylhydroxylysine
show the reaction diagram
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TDP-glucose + an arylamine = TDP + an N-D-glucosylarylamine
show the reaction diagram
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TDP-glucose + N-acylsphingosine = TDP + D-glucosyl-N-acylsphingosine
show the reaction diagram
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TDP-glucose + luteolin = TDP + 7-O-beta-D-glucosylluteolin
show the reaction diagram
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dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + O-alpha-L-dihydrostreptosyl-1,4-streptidine 6-phosphate
show the reaction diagram
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TTP + D-glucose = TDP + D-glucose 6-phosphate
show the reaction diagram
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TTP + D-fructose 6-phosphate = TDP + D-fructose 1,6-bisphosphate
show the reaction diagram
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dTTP + deoxyguanosine = dTDP + dGMP
show the reaction diagram
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TTP + D-tagatose 6-phosphate = TDP + D-tagatose 1,6-bisphosphate
show the reaction diagram
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TTP + (R)-glycerate = TDP + 2-phospho-(R)-glycerate
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TTP + adenosine = TDP + AMP
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TTP + glycerol = TDP + glycerol 3-phosphate
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pantothenate + dTTP = 4'-phosphopantothenate + dTDP
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TTP + D-fructose = TDP + D-fructose 6-phosphate
show the reaction diagram
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TTP + 2-dehydro-3-deoxy-D-gluconate = TDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
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dTTP + uridine = dTDP + UMP
show the reaction diagram
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TTP + 4-methyl-5-(2-hydroxyethyl)thiazole = TDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
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TTP + D-fructose 1-phosphate = TDP + D-fructose 1,6-bisphosphate
show the reaction diagram
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TTP + glucose = TDP + D-glucose 6-phosphate
show the reaction diagram
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TTP + 1-phosphatidyl-1D-myo-inositol = TDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
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TTP + D-mannose = TDP + D-mannose 6-phosphate
show the reaction diagram
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TTP + 5'-dephospho-DNA = TDP + 5'-phospho-DNA
show the reaction diagram
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TTP + inosine = TDP + inosine 5'-phosphate
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TTP + acetate = TDP + acetyl phosphate
show the reaction diagram
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2'-dTTP + 3-phospho-D-glycerate = 2'-dTDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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ATP + dTMP = ADP + dTDP
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TTP + (R,S)-5-phosphomevalonate = TDP + (R,S)-5-diphosphomevalonate
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ATP + TMP = ADP + TDP
show the reaction diagram
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TMP + [phosphate]n = TDP + [phosphate]n-1
show the reaction diagram
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dTTP + H2O = dTDP + phosphate
show the reaction diagram
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dTTP + H2O = dTDP + phosphate
show the reaction diagram
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TTP + H2O = TDP + phosphate
show the reaction diagram
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TTP + H2O = TDP + phosphate
show the reaction diagram
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dTTP + H2O = dTDP + phosphate
show the reaction diagram
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TTP + oxaloacetate = TDP + phosphoenolpyruvate + CO2
show the reaction diagram
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TTP + H2O + a dynein associated with a microtubule at position n = TDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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TTP + H2O + polypeptide = TDP + phosphate + unfolded polypeptide
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TTP + H2O + actin = TDP + phosphate + actin
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TTP + L-Glu + NH4+ = TDP + phosphate + L-Gln
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dTTP + 5-formyltetrahydrofolate = dTDP + phosphate + 5,10-methylenetetrahydrofolate
show the reaction diagram
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TTP + (7R,8S)-7,8-diaminopelargonic acid + NaHCO3 = TDP + phosphate + dethiobiotin + Na+ + OH-
show the reaction diagram
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ITP + H2O + H+/in + K+/out = TDP + phosphate + H+/out + K+/in
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits at low concentrations, stimulates at high concentrations
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 620% activation of mitochondrial deoxyguanosine kinase, positive modulation with ATP as substrate
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activation
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activation of hydrolysis of 3'-dTMP
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Inhibitor in Enzyme-catalyzed Reactions (145 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits at low concentrations, stimulates at high concentrations
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1 mM, 14% inhibition
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1 mM, 18% inhibition
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weak
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inhibits uridylyl removing activity
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slight inhibition, competitive inhibitor, mechanism of inhibition
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with dTTP or dUTP as substrate
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0.2 mM, 64% inhibition; 0.2 mM, 93% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (42 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
69
-
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1.03
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substrate concentration between 0.01 and 4.0 mM, 37°C
80.2
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recombinant wild-type enzyme, pH 7.4, 25°C
87
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pH 4.5, 37°C; pH 4.5, 37°C

KM Value (23 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.476
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0.032
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0.105
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substrate concentration between 0.01 and 4.0 mM, 37°C
0.7495
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recombinant wild-type enzyme, pH 7.4, 25°C

Ki Value (14 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
1.93
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UDP-galactose 0.1-16 mM, TDP 0-4 mM
11693
1.93
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purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
11542
5.3
-
-
11606
0.5
0.65
pH 7.5, 27°C
14373
0.00267
-
pH 7.5, 30°C
39590

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.006
-
pH 7.5, 30°C

References & Links

Links to other databases for dTDP

ChEBI
PubChem
ChEBI
PubChem