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Ligand 8-bromo-GTP Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 0 H1 5 BrN5 O1 4 P3
8-bromo-GTP
CNYUHYBBHQMZQJ-UMMCILCDSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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8-bromo-GTP + pp(5')RNA = 8-bromo-G(5')ppp(5')RNA + diphosphate
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8-bromo-GTP + H2O = 8-bromo-GDP + phosphate
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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0.1 mM, 50% inhibition of GTP cyclohydrolase activity, 0.1 mM, 64% inhibition of diphosphate phosphohydrolase activity
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Enzyme Kinetic Parameters
IC50 Value (1 result)
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1.5
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IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
References & Links Literature References (3)
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A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates
2002
Graham, D.E.; Xu, H.; White, R.H.
Biochemistry
41
15074-15084
Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase
2010
Despins, S.; Issur, M.; Bougie, I.; Bisaillon, M.
Nucleic Acids Res.
38
5493-5506
Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism
2013
Issur, M.; Bougie, I.; Despins, S.; Bisaillon, M.
PLoS ONE
8
e75310
Links to other databases for 8-bromo-GTP
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