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Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome
2011
Nakano, C.; Ootsuka, T.; Takayama, K.; Mitsui, T.; Sato, T.; Hoshino, T.
Biosci. Biotechnol. Biochem.
75
75-81
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis
2011
Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T.
Org. Biomol. Chem.
9
2156-2165
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Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates
2010
Nakano, C.; Hoshino, T.; Sato, T.; Toyomasu, T.; Dairi, T.; Sassa, T.
Tetrahedron Lett.
51
125-128
Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis
2014
Chan, H.C.; Feng, X.; Ko, T.P.; Huang, C.H.; Hu, Y.; Zheng, Y.; Bogue, S.; Nakano, C.; Hoshino, T.; Zhang, L.; Lv, P.; Liu, W.; Crick, D.C.; Liang, P.H.; Wang, A.H.; Oldfield, E.; Guo, R.T.
J. Am. Chem. Soc.
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In vivo biosynthesis of terpene nucleosides provides unique chemical markers of mycobacterium tuberculosis infection
2015
Young, D.; Layre, E.; Pan, S.; Tapley, A.; Adamson, J.; Seshadri, C.; Wu, Z.; Buter, J.; Minnaard, A.; Coscolla, M.; Gagneux, S.; Copin, R.; Ernst, J.; Bishai, W.; Snider, B.; Moody, D.
Chem. Biol.
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516-526
In vivo biosynthesis of terpene nucleosides provides unique chemical markers of mycobacterium tuberculosis infection
2015
Young, D.; Layre, E.; Pan, S.; Tapley, A.; Adamson, J.; Seshadri, C.; Wu, Z.; Buter, J.; Minnaard, A.; Coscolla, M.; Gagneux, S.; Copin, R.; Ernst, J.; Bishai, W.; Snider, B.; Moody, D.
Chem. Biol.
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Heterologous production of 1-tuberculosinyladenosine in Mycobacterium kansasii models pathoevolution towards the transcellular lifestyle of mycobacterium tuberculosis
2020
Ghanem, M.; Dubé, J.; Wang, J.; McIntosh, F.; Houle, D.; Domenech, P.; Reed, M.; Raman, S.; Buter, J.; Minnaard, A.; Branch Moody, D.; Behra, M.
mBio
11
1-15
Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c
2014
Layre, E.; Lee, H.J.; Young, D.C.; Martinot, A.J.; Buter, J.; Minnaard, A.J.; Annand, J.W.; Fortune, S.M.; Snider, B.B.; Matsunaga, I.; Rubin, E.J.; Alber, T.; Moody, D.B.
Proc. Natl. Acad. Sci. USA
111
2978-2983
Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c
2014
Layre, E.; Lee, H.J.; Young, D.C.; Martinot, A.J.; Buter, J.; Minnaard, A.J.; Annand, J.W.; Fortune, S.M.; Snider, B.B.; Matsunaga, I.; Rubin, E.J.; Alber, T.; Moody, D.B.
Proc. Natl. Acad. Sci. USA
111
2978-2983
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