Ligand 6-Thiourate
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Basic Ligand Information
C5H4N4O2S
6-Thiourate
SXHQUGJSTGOXMD-UHFFFAOYSA-N
2,8-dihydroxy-6-mercaptopurine, 2,8-Dihydroxy-6-thiopurine, 6-Thiouric acid
Related pathways
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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6-mercaptopurine + 2 H2O + 2 O2 = 6-thiouric acid + 2 H2O2
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Substrate in Enzyme-catalyzed Reactions (2 results)
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S-adenosyl-L-methionine + 2,8-dihydroxy-6-thiopurine = S-adenosyl-L-homocysteine + 2,8-dihydroxy-6-methylthiopurine
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S-adenosyl-L-methionine + 6-thiouric acid = S-adenosyl-L-homocysteine + 6-methylthiouric acid
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Product in Enzyme-catalyzed Reactions (6 results)
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6-thioxanthine + NAD+ + H2O = 6-thiourate + NADH
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6-thioxanthine + NAD+ + H2O = 6-thiourate + NADH + H+
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6-thioxanthine + H2O + O2 = 6-thiourate + H2O2
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6-mercaptopurine + 2 H2O + 2 O2 = 6-thiouric acid + 2 H2O2
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6-thioxanthine + H2O + O2 = 6-thiouric acid + H2O2
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6-thioxanthine + H2O + O2 = 6-thiouric acid + H2O2
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
References & Links
Literature References (5)
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Molybdenum iron-sulfur flavin hydroxylases and related enzymes
1975
Bray, R.C.
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
12
299-419
Metabolism of thiopyrimidines and thiopurines
1963
Remy, C.N.
J. Biol. Chem.
238
1078-1084
Purine substrates for human thiopurine methyltransferase
1994
Deininger, M.; Szumlanski, C.L.; Otterness, D.M.; Van Loon, J.; Ferber, W.; Weinshilboum, R.M.
Biochem. Pharmacol.
48
2135-2138
Human thiopurine methyltransferase: no evidence of activation by its substrates
1997
Stupans, I.; Kirlich, A.; McKinnon, R.A.
Life Sci.
62
343-350
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Purification, crystallization, and some properties of xanthine dehydrogenase from Pseudomonas synxantha A 3
1979
Sakai, T.; Jun, H.K.
Agric. Biol. Chem.
43
753-760
Links to other databases for 6-Thiourate
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