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BRENDA support

Ligand neocuproine

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Basic Ligand Information

Molecular Structure
Picture of neocuproine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C14H12N2
neocuproine
IYRGXJIJGHOCFS-UHFFFAOYSA-N
Synonyms:
2,9-Dimethyl-1,10-phenanthroline, neo-cuproine, Neocuprein, neocuproin

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
without protein-A: slight activation at 0.1 mM
-
1.0 mM, relative activity 106%
-

Inhibitor in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 65% inhibition
-
50% inhibition at 5 mM
-
0.001 mM, 92% inhibition
-
45-55% inhibition at 10 mM
-
with protein-A: 18% inhibition at 0.1 mM, without protein-A: slight activation at 0.1 mM
-
reversible by addition of Cu2+
-
55% inhibition at 0.1 mM
-
50% inhibition at 0.1 mM
-
0.033 mM, 61% inhibition
-
slight
-
some inhibition
-
1 mM, 39% residual activity
-
slight inhibition
-
i.e. 2,9-dimethyl-1,10-phenanthroline, 0.1 mM Zn2+ stabilizes the activity
-
2.0 mM, 52% inhibition
-
2,9-dimethyl-1,10-phenanthroline
-

Enzyme Kinetic Parameters

References & Links

Links to other databases for neocuproine

EXTERNAL LINKS