print visible entries

print all entries

Ligand 6-methylthiopurine

Basic Ligand Information

Molecular Structure

Related pathways

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.67

S-adenosyl-L-methionine + 6-mercaptopurine = S-adenosyl-L-homocysteine + 6-methylmercaptopurine

-

-

2.1.1.67

S-adenosyl-L-methionine + 6-thiopurine = S-adenosyl-L-homocysteine + 6-methylthiopurine

-

-

2.1.1.67

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether

-

-

2.1.1.67

3 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.3.1

6-methylthiopurine + H2O + O2 = 6-methylthio-8-hydroxypurine + H2O2

390418

-

Product in Enzyme-catalyzed Reactions (10 results)

top print hide

Show Product (10 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.67

S-(5'-adenosyl)-L-methionine-d3 disulfate salt + 6-mercaptopurine = S-adenosyl-L-homocysteine + 6-(d3-methyl)mercaptopurine

-

-

2.1.1.67

S-adenosyl-L-methionine + 6-mercaptopurine = S-adenosyl-L-homocysteine + 6-methylmercaptopurine

-

-

2.1.1.67

S-adenosyl-L-methionine + azathioprine = S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?

-

-

2.1.1.67

S-adenosyl-L-methionine + 6-thiopurine = S-adenosyl-L-homocysteine + 6-methylthiopurine

-

-

2.1.1.67

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether

-

-

2.1.1.67

S-adenosyl-L-methionine + mercaptopurine = S-adenosyl-L-homocysteine + methylmercaptopurine

-

-

2.1.1.67

S-adenosyl-L-methionine + thiopurine = S-adenosyl-L-homocysteine + methylthiopurine

-

-

2.1.1.67

7 entries

2.1.1.9

6-thiopurine + S-adenosyl-L-methionine = S-methyl-6-thiopurine + S-adenosyl-L-homocysteine

441585

-

2.4.2.1

9-beta-D-(2-deoxyribofuranosyl)-6-methylthiopurine + phosphate = 6-methylthiopurine + 2-deoxy-alpha-D-ribose 1-phosphate

-

-

2.4.2.1

9-beta-D-ribofuranosyl-6-methylthiopurine + phosphate = 6-methylthiopurine + alpha-D-ribose 1-phosphate

-

-

2.4.2.1

2 entries

Inhibitor in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.67

-

485516

-

2.1.1.67

-

485515

-

2.1.1.67

2 entries

2.4.2.1

-

489654

-

Enzyme Kinetic Parameters

K_M Value (2 results)

top print hide

Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.3.1

0.2

-

O2 as electron acceptor

390418

1.2.3.1

0.3

-

2,6-dichlorophenol indophenol as electron acceptor

390418

1.2.3.1

2 entries

K_i Value (1 result)

top print hide

Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.2.1

0.13

-

-

489654

References & Links

Literature References (5)

top print hide

Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

390418

-

Enzymic hydroxylation of 6-methylthiopurine by hepatic aldehyde oxidase

1967

Loo, T.L.; Lim, C.; Johns, D.G.

Biochim. Biophys. Acta

134

467-469

441585

485170

Thiol S-methyltransferase from rat liver

1979

Weisiger, R.A.; Jakoby, W.B.

Arch. Biochem. Biophys.

196

631-637

485515

13981612

Metabolism of thiopyrimidines and thiopurines

1963

Remy, C.N.

J. Biol. Chem.

238

1078-1084

485516

6838629

Human kidney thiopurine methyltransferase. Purification and biochemical properties

1983

Woodson, L.C.; Weinshilboum, R.M.

Biochem. Pharmacol.

32

819-826

489654

-

Purine nucleoside phosphorylase

1972

Parks, R.E.; Agarwal, R.P.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

7

483-514

Links to other databases for 6-methylthiopurine

top print hide

Show Links (1 entry)