Ligand glycyrrhizinic acid

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Basic Ligand Information

Molecular Structure
Picture of glycyrrhizinic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C42H62O16
glycyrrhizinic acid
LPLVUJXQOOQHMX-QWBHMCJMSA-N
Synonyms:
(3beta)-30-hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid, glycyrrhizic acid, glycyrrhizin, glycyrrhizinate, glycyrrhizininc acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycyrrhizinic acid + H2O = glycyrrhetinic acid + D-glucuronyl beta-1,2-D-glucuronic acid
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycyrrhizin + H2O = glycyrrhetinic acid + 2 D-glucuronate
show the reaction diagram
-
glycyrrhizin + H2O = glycyrrhetinate 3-O-beta-D-glucuronide + D-glucuronate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slightly activates isozyme NAT1
-

Inhibitor in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits the crude enzyme activity when concentration is up to 60 mM
-
from roots of Glycyrrhiza uralensis , Glycyrrhiza inflata, or Glycyrrhiza glabra
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
6
-
pH 4.5, 45C

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10.98
-
-
0.12
-
-
0.54
-
pH 4.5, 45C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (13 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.08
-
IC50: 0.08 mM, competitive
0.026
-
at pH 3.5
0.0571
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37C

References & Links

Links to other databases for glycyrrhizinic acid

ChEBI
PubChem
ChEBI
PubChem