We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand 3'-O-Methyl-GTP Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 1 H1 8 N5 O1 4 P3
3'-O-Methyl-GTP
OHOBECDATGAGJW-KQYNXXCUSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3'-O-methyl-GTP + mRNA = ?
-
3'-O-methyl-GTP + pp(5')RNA = 3'-O-methyl-G(5')ppp(5')RNA + diphosphate
-
3'-O-methyl-GTP + H2O = 3'-O-methyl-GDP + phosphate
-
Activator in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Inhibitor in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Enzyme Kinetic Parameters
IC50 Value (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.45
-
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
References & Links Literature References (5)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ornithine decarboxylase activity from an extremely thermophilic bacterium, Clostridium thermohydrosulfuricum
1983
Paulin, L.; Poesoe, H.
Biochim. Biophys. Acta
742
197-205
Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase
2010
Despins, S.; Issur, M.; Bougie, I.; Bisaillon, M.
Nucleic Acids Res.
38
5493-5506
Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism
2013
Issur, M.; Bougie, I.; Despins, S.; Bisaillon, M.
PLoS ONE
8
e75310
The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation
2019
Fujiwara, R.; Damodaren, N.; Wilusz, J.; Murakami, K.
Proc. Natl. Acad. Sci. USA
116
22573-22582
The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation
2019
Fujiwara, R.; Damodaren, N.; Wilusz, J.; Murakami, K.
Proc. Natl. Acad. Sci. USA
116
22573-22582
Links to other databases for 3'-O-Methyl-GTP
close all tables 
open all tables
top
