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Ligand methylated histone

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for methylated histone

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.127

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485354, 485355

-

2.1.1.354

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485355

-

2.1.1.355

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485355, 485353

-

2.1.1.360

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

-

-

2.1.1.362

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485352

-

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.61

methylated histones + H2O = histones + methanol

646054

-

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.127

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485354, 485355

-

2.1.1.354

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485355

-

2.1.1.355

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485355, 485353, -

-

2.1.1.360

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

-

-

2.1.1.362

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

485352

-

2.1.1.364

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

-

-

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.48

stimulates interaction of NuA4 complex with histone

705700

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.1.61

0.0005

-

pH 6.0, 37°C

646054

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

485352

12121615

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase

2002

Fang, J.; Feng, Q.; Ketel, C.S.; Wang, H.; Cao, R.; Xia, L.; Erdjument-Bromage, H.; Tempst, P.; Simon, J.A.; Zhang, Y.

Curr. Biol.

12

1086-1099

485353

12130538

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

2002

Tachibana, M.; Sugimoto, K.; Nozaki, M.; Ueda, J.; Ohta, T.; Ohki, M.; Fukuda, M.; Takeda, N.; Niida, H.; Kato, H.; Shinkai, Y.

Genes Dev.

16

1779-1791

485354

12372303

Structure and catalytic mechanism of a SET domain protein methyltransferase

2002

Trievel, R.C.; Beach, B.M.; Dirk, L.M.A.; Houtz, R.L.; Hurley, J.H.

Cell

111

91-103

485355

12372294

Structures of SET domain proteins: protein lysine methyltransferases make their mark

2002

Yeates, T.O.

Cell

111

5-7

646054

2549948

Mammalian protein methylesterase. Physical and enzymic properties

1989

Veeraragavan, K.; Gagnon, C.

Biochem. J.

260

11-17

705700

19822662

NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5

2009

Ginsburg, D.S.; Govind, C.K.; Hinnebusch, A.G.

Mol. Cell. Biol.

29

6473-6487

Links to other databases for methylated histone

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Show Links (1 entry)