Ligand dUTP

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Basic Ligand Information

Molecular Structure
Picture of dUTP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H15N2O14P3
dUTP
AHCYMLUZIRLXAA-SHYZEUOFSA-N
Synonyms:
deoxyuridinetriphosphate


Show all pahtways known for Show all BRENDA pathways known for dUTP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dUTP + H2O = dUDP + phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dCTP + H2O = dUTP + NH3
show the reaction diagram
-
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Substrate in Enzyme-catalyzed Reactions (40 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dUTP + deoxyguanosine = dUDP + dGMP
show the reaction diagram
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dUTP + 4-methyl-5-(2-hydroxyethyl)thiazole = dUDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
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dUTP + D-galactose = dUDP + alpha-D-galactose 1-phosphate
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dUTP + 2'-deoxycytidine = dUDP + 2'-deoxy-CMP
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dUTP + CMP = dUDP + CDP
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dUTP + CMP = dUDP + CDP
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ADP + dUTP = ATP + dUDP
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D-galactose 1-phosphate + dUTP = dUDP-D-galactose + diphosphate
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dUTP + dihydrouracil + H2O = ?
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dUTP + H2O = dUMP + diphosphate
show the reaction diagram
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dUTP + H2O = dUDP + phosphate
show the reaction diagram
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dUTP + H2O = dUMP + phosphate + H+
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dUTP + H2O = ?
show the reaction diagram
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dUTP + H2O = dUMP + diphosphate
show the reaction diagram
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dUTP + H2O = dUMP + diphosphate
show the reaction diagram
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dUTP + H2O = dUDP + phosphate
show the reaction diagram
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dUTP + H2O + closed Cl- channel = dUDP + phosphate + open Cl- channel
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ATP + dUTP + NH4+ = ADP + phosphate + dCTP
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UTP + formate = dUTP + CO2 + H2O
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UTP + reduced thioredoxin = dUTP + oxidized thioredoxin + H2O
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ATP + dUDP = ADP + dUTP
show the reaction diagram
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dCTP + H2O = dUTP + NH3
show the reaction diagram
-
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dCTP + H2O = dUTP + NH3
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, with ATP as substrate, at pH 7
-
89% activation
-
at least 2fold enhancement of enzyme activity, maximal at 20 microM, similar results with all four deoxynucleoside triphosphates
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Inhibitor in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of: CDP reduction, UDP reduction
-
80% inhibition at 1 mM
with dTTP as substrate
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3D Structure of Enzyme-Ligand-Complex (PDB) (13 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (54 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
219
-
pH not specified in the publication, temperature not specified in the publication
14.8
-
pH 6.6, 25°C

KM Value (73 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.025
-
pH 7.5
3.74
-
pH not specified in the publication, temperature not specified in the publication
0.011
-
-
0.93
-
pH 6.6, 25°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.5
-
-
34334

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.187
-
pH 7.4, 37°C
0.24
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wild type enzyme, at pH 7.4 and 30°C

References & Links

Links to other databases for dUTP

ChEBI
PubChem
ChEBI
PubChem