Ligand Oxalomalate

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Basic Ligand Information

Molecular Structure
Picture of Oxalomalate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6O8
Oxalomalate
YILAUJBAPQXZGM-UHFFFAOYSA-K
Synonyms:
3-Oxalomalate, oxalomalic acid
Pathway Source
Pathways

Roles as Enzyme Ligand

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
Oxaloacetate + glyoxylate = 3-Oxalomalate
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
competitive, coadministration with CD2+ results in inhibition of enzyme and glutaredoxin and enhanced susceptibility to apoptosis
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competitive
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inhibition of aconitase activity, leading to inhibition of L-glutamate production, L-cystine uptake, and decrease in glutathione concentration in lens epithelial cells and retinal pigment epithelial cells
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inhibition of the enzyme by oxalomalate reduces glutamate secretion and eliminates the effect of iron ions on the latter
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significantly increases citrate content and reduces the enzyme's activity, while slightly inducing its protein level. Specific activities of amino acid-metabolizing enzymes are induced in oxalomalate-treated callus cells, overview
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Enzyme Kinetic Parameters

References & Links

Links to other databases for Oxalomalate

ChEBI
PubChem
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PubChem