Ligand 2-hydroxybenzoyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of 2-hydroxybenzoyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C28H40N7O18P3S
2-hydroxybenzoyl-CoA
YTKKDFTVSNSVEE-TYHXJLICSA-N
Synonyms:
2-hydroxy-benzoyl-CoA, salicyl-CoA, salicyloyl-CoA, salicylyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-hydroxybenzoyl-CoA + NADH + H+ + O2 = gentisyl-CoA + NAD+ + H2O
show the reaction diagram
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malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2
show the reaction diagram
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2-hydroxybenzoyl-CoA + H2O = 2-hydroxybenzoate + CoA
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-hydroxybenzoyl-CoA + NADH + H+ + O2 = gentisyl-CoA + NAD+ + H2O
show the reaction diagram
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2-hydroxybenzoyl-CoA + NAD(P)H + O2 = ?
show the reaction diagram
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2-hydroxy-benzoyl-CoA + reduced methyl viologen + ATP = 2-hydroxy-cyclohexa-1,5-diene-1-carbonyl-CoA + methyl viologen + ADP + phosphate
show the reaction diagram
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salicyl-CoA + glycine = CoA + N-salicylglycine
show the reaction diagram
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salicyl-CoA + anthranilate = CoA + N-salicylanthranilate
show the reaction diagram
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3 malonyl-CoA + salicyl-CoA = 4 CoA + 4-hydroxy-2H-chromen-2-one + 3 CO2
show the reaction diagram
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malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2
show the reaction diagram
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salicylyl-CoA + H2O = CoA + salicylate
show the reaction diagram
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2-hydroxybenzoyl-CoA + H2O = 2-hydroxybenzoate + CoA
show the reaction diagram
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salicylyl-CoA + H2O = CoA + salicylate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + salicylate + CoA = AMP + diphosphate + salicyl-CoA
show the reaction diagram
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-
ATP + 2-hydroxybenzoate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
93
-
pH 7.0, 25°C

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.056
-
-
7.6
-
reaction with salicylyl-CoA
0.073
-
pH 7.0, 25°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.006
-
pH 7,0, 23°C

References & Links

Links to other databases for 2-hydroxybenzoyl-CoA

ChEBI
PubChem
ChEBI
PubChem