Ligand UDP-alpha-D-glucose

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Basic Ligand Information

Molecular Structure

C₁₅H₂₄N₂O₁₇P₂

UDP-alpha-D-glucose

HSCJRCZFDFQWRP-JZMIEXBBSA-N

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Synonyms:

alpha-UDP-glucose, UDP-alpha-D-glucopyranose, UDP-D-Glc, UDP-D-glucose, UDP-Glc, UDP-glucose, UDP-monosaccharide, UDP-sugar, UDPalpha-D-glucose, UDPGlc, UDPglucose, uridine 5'-diphosphoglucose, Uridine diphosphoglucose, [U-14C]-UDP-glucose

Related pathways

BRENDA

benzoxazinoid glucosides biosynthesis, C30 carotenoid biosynthesis, degradation of hexoses, dolichyl-diphosphooligosaccharide biosynthesis, ginsenoside metabolism

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KEGG

Amino sugar and nucleotide sugar metabolism, Ascorbate and aldarate metabolism, Biosynthesis of ansamycins, Biosynthesis of cofactors, Biosynthesis of nucleotide sugars

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MetaCyc

(+)-secoisolariciresinol diglucoside biosynthesis, 1,3-beta-D-glucan biosynthesis, 2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis, 2,4,6-trinitrotoluene degradation, 3,4-dihydroxymandelonitrile beta-D-glucose biosynthesis, 6'-deoxychalcone metabolism, abscisic acid degradation by glucosylation, acetan biosynthesis, acylated cyanidin galactoside biosynthesis, afrormosin conjugates interconversion, ajmaline and sarpagine biosynthesis, alpha-diglucosyldiacylglycerol biosynthesis, alpha-solanine/alpha-chaconine biosynthesis, alpha-tomatine biosynthesis, ansamitocin P biosynthesis, anthocyanidin modification (Arabidopsis), anthocyanidin sambubioside biosynthesis, anthocyanidin sophoroside metabolism, anthocyanin biosynthesis, anthocyanin biosynthesis (delphinidin 3-O-glucoside), anthocyanin biosynthesis (pelargonidin 3-O-glucoside), apigenin glycosides biosynthesis, apigeninidin 5-O-glucoside biosynthesis, aurone biosynthesis, avenacin A-1 biosynthesis, baicalein metabolism, benzoyl-beta-D-glucopyranose biosynthesis, betacyanin biosynthesis, biochanin A conjugates interconversion, brassinosteroids inactivation, C25,25 CDP-archaeol biosynthesis, calycosin 7-O-glucoside biosynthesis, cardenolide glucosides biosynthesis, cellulose biosynthesis, chalcone 2'-O-glucoside biosynthesis, cichoriin interconversion, cinnamate esters biosynthesis, colanic acid (Escherichia coli K12) biosynthesis, colanic acid building blocks biosynthesis, coniferin metabolism, coumarin biosynthesis (via 2-coumarate), crocetin biosynthesis, crocetin esters biosynthesis, curcumin glucoside biosynthesis, cytokinin-O-glucosides biosynthesis, cytokinins 7-N-glucoside biosynthesis, cytokinins 9-N-glucoside biosynthesis, D-galactose degradation I (Leloir pathway), D-galactose detoxification, daidzein conjugates interconversion, daphnetin modification, daphnin interconversion, decaprenoxanthin diglucoside biosynthesis, des-methyl avenacin A-1 biosynthesis, dhurrin biosynthesis, DIBOA-glucoside biosynthesis, Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis, Escherichia coli serotype O:117 O antigen biosynthesis, Escherichia coli serotype O:152 O antigen biosynthesis, Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis, Escherichia coli serotype O:169 O antigen biosynthesis, Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis, Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis, Escherichia coli serotype O:56 O antigen biosynthesis, esculetin modification, eupatolitin 3-O-glucoside biosynthesis, flavonoid di-C-glucosylation, flavonol acylglucoside biosynthesis I - kaempferol derivatives, flavonol acylglucoside biosynthesis II - isorhamnetin derivatives, flavonol acylglucoside biosynthesis III - quercetin derivatives, formononetin conjugates interconversion, furaneol and mesifurane biosynthesis, galactolipid biosynthesis II, galloylated catechin biosynthesis, ganglio-series glycosphingolipids biosynthesis, genistein conjugates interconversion, genistin gentiobioside biosynthesis, gentiodelphin biosynthesis, geranyl beta-primeveroside biosynthesis, ginsenosides biosynthesis, globo-series glycosphingolipids biosynthesis, glucosinolate biosynthesis from dihomomethionine, glucosinolate biosynthesis from hexahomomethionine, glucosinolate biosynthesis from homomethionine, glucosinolate biosynthesis from pentahomomethionine, glucosinolate biosynthesis from phenylalanine, glucosinolate biosynthesis from tetrahomomethionine, glucosinolate biosynthesis from trihomomethionine, glucosinolate biosynthesis from tryptophan, glucosinolate biosynthesis from tyrosine, glycogen biosynthesis II (from UDP-D-Glucose), gossypetin metabolism, H. pylori 26695 O-antigen biosynthesis, hesperitin glycoside biosynthesis, hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis, indican biosynthesis, indole-3-acetate inactivation III, indole-3-acetate inactivation IX, isoorientin biosynthesis II, isovitexin glycosides biosynthesis, jasmonoyl-L-isoleucine inactivation, kaempferide triglycoside biosynthesis, kaempferol diglycoside biosynthesis (pollen-specific), kaempferol gentiobioside biosynthesis, kaempferol glycoside biosynthesis (Arabidopsis), kaempferol triglucoside biosynthesis, kanamycin biosynthesis, kanosamine biosynthesis I, lacto-series glycosphingolipids biosynthesis, lauryl-hydroxychlorobactene glucoside biosynthesis, leucine-derived hydroxynitrile glucoside biosynthesis, linamarin biosynthesis, lipid A-core biosynthesis (Brucella), lipid A-core biosynthesis (E. coli K-12), lipid A-core biosynthesis (H. pylori), lipid A-core biosynthesis (Salmonella), lotaustralin biosynthesis, luteolin glycosides biosynthesis, luteolinidin 5-O-glucoside biosynthesis, maackiain conjugates interconversion, mannosylglucosylglycerate biosynthesis I, medicarpin conjugates interconversion, monolignol glucosides biosynthesis, mycofactocin biosynthesis, mycolyl-arabinogalactan-peptidoglycan complex biosynthesis, myricetin gentiobioside biosynthesis, N-glucosylnicotinate metabolism, N-methylanthraniloyl-beta-D-glucopyranose biosynthesis, naringenin C-glucosylation, naringenin glycoside biosynthesis, neolacto-series glycosphingolipids biosynthesis, oleandomycin activation/inactivation, orientin and isoorientin biosynthesis I, pelargonidin conjugates biosynthesis, pentagalloylglucose biosynthesis, phenolic malonylglucosides biosynthesis, phenylethanol glycoconjugate biosynthesis, phenylpropanoid volatiles glycoconjugation (tomato), phloridzin biosynthesis, pinocembrin C-glucosylation, podophyllotoxin glucosides metabolism, poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis, poly(glycerol phosphate) wall teichoic acid biosynthesis, poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis), polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium), polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium), Porphyromonas gingivalis O-LPS antigen biosynthesis, proanthocyanidins biosynthesis from flavanols, procollagen hydroxylation and glycosylation, protein N-glycosylation (bacterial), protein N-glycosylation (Haloferax volcanii), protein N-glycosylation initial phase (eukaryotic), protein O-glycosylation (Neisseria), prunasin and amygdalin biosynthesis, quercetin diglycoside biosynthesis (pollen-specific), quercetin gentiotetraside biosynthesis, quercetin glucoside biosynthesis (Allium), quercetin glycoside biosynthesis (Arabidopsis), quercetin triglucoside biosynthesis, rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside), rose anthocyanin biosynthesis II (via cyanidin 3-O-beta-D-glucoside), rutin biosynthesis, salicin biosynthesis, salicortin biosynthesis, salicylate glucosides biosynthesis II, salicylate glucosides biosynthesis III, salicylate glucosides biosynthesis IV, salidroside biosynthesis, salmochelin biosynthesis, salvianin biosynthesis, saponin biosynthesis II, saponin biosynthesis III, saponin biosynthesis IV, sarcinaxanthin diglucoside biosynthesis, secologanin and strictosidine biosynthesis, sesaminol glucoside biosynthesis, shisonin biosynthesis, sinapate ester biosynthesis, solasodine glycosylation, sophorolipid biosynthesis, sphingolipid biosynthesis (plants), stachyose degradation, steviol glucoside biosynthesis (rebaudioside A biosynthesis), succinoglycan biosynthesis, sucrose biosynthesis I (from photosynthesis), sucrose biosynthesis II, sucrose biosynthesis III, sucrose degradation II (sucrose synthase), sulfoquinovosyl diacylglycerol biosynthesis, superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside), superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside), superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside), superpathway of indole-3-acetate conjugate biosynthesis, superpathway of methylsalicylate metabolism, superpathway of scopolin and esculin biosynthesis, superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis, taxiphyllin biosynthesis, teichuronic acid biosynthesis (B. subtilis 168), ternatin C5 biosynthesis, trehalose biosynthesis I, trehalose biosynthesis VII, trichloroethene degradation, tropane alkaloids biosynthesis, tuberonate glucoside biosynthesis, type I lipoteichoic acid biosynthesis (S. aureus), type IV lipoteichoic acid biosynthesis (S. pneumoniae), UDP-alpha-D-galactose biosynthesis, UDP-alpha-D-glucose biosynthesis, UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose), UDP-beta-L-rhamnose biosynthesis, validamycin biosynthesis, vitexin and derivatives biosynthesis, wogonin metabolism, xanthan biosynthesis, xyloglucan biosynthesis, zeaxanthin-beta-D-diglucoside biosynthesis

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Show all BRENDA pathways known for UDP-alpha-D-glucose

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (472 results)

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UDP-glucose + vitexin = UDP + vitexin 2''-O-beta-D-glucoside

488401

2.4.1.106

UDP-glucose + isovitexin = UDP + isovitexin 2''-O-beta-D-glucoside

UDPglucose + coniferyl alcohol = ?

488455, 488456, 488454

2.4.1.114

UDP-glucose + 2-hydroxycinnamate = UDP + (2E)-3-[2-(beta-D-glucopyranosyloxy)phenyl]prop-2-enoic acid

UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate

488480

2.4.1.118

UDPglucose + N6-alkylaminopurine = UDP + N6-alkylaminopurine-7-beta-D-glucoside

UDP-alpha-D-glucose + 4-hydroxycinnamate = UDP + 4-O-(beta-D-glucopyranosyl)-4-hydroxycinnamate

706373

2.4.1.127

UDPglucose + L-menthol = UDP + L-menthyl-beta-D-glucoside

UDPglucose + pyridoxine = UDP + 5'-O-beta-D-glucosylpyridoxine

488674

2.4.1.168

UDP-D-glucose + xyloglucan = UDP + glucosylxyloglucan

UDPglucose + methylazoxymethanol = UDP + cycasin

488804

2.4.1.172

UDPglucose + salicyl alcohol = UDP + salicin

UDPglucose + gibberellin GA3 = UDP + gibberellin GA3-O(3)-beta-D-glucopyranoside

UDP-glucose + a hydroxyanthraquinone = UDP + a glucosyloxyanthraquinone

UDP-glucose + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol

488821

2.4.1.192

UDP-glucose + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol = UDP + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucoside

488871

2.4.1.193

UDPglucose + (25S)-5beta-spirostan-3beta-ol = UDP + (25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucoside

488872

2.4.1.195

UDPglucose + phenylacetothiohydroximate = UDP + desulfoglucotropeolin

643821, 644891, 644886, 643823, 643822, 644892, 644890

2.4.1.196

UDPglucose + nicotinate = ?

637797

2.4.1.202

UDP-glucose + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one = UDP + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside

UDP-glucose + hydroquinone = UDP + hydroquinone-O-beta-D-glucopyranoside

658631, 735733

2.4.1.219

UDP-glucose + vomilenine = UDP + raucaffricine

488935, 488936, 488934, 488937, 488938

UDP-glucose + glucosylhydroxymethylcytosine residue in DNA = UDP + beta-D-glucosyl-beta-D-glucosyl-hydroxymethylcytosine containing DNA

489024

2.4.1.293

UDP-alpha-D-glucose + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol = UDP + [GalNAc-alpha-(1->4)]2-[Glc-beta-(1->3)]-[GalNAc-alpha-(1->4)]2-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol

714160, 719705, 720888

2.4.1.295

UDP-alpha-D-glucose + an anthocyanidin 3-O-beta-D-sambubioside = UDP + an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside

UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + beta-D-Glc-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol

722520

2.4.1.310

UDP-alpha-D-glucose + vancomycin aglycone = UDP + devancoaminyl vancomycin

721585, 489094

2.4.1.314

UDP-alpha-D-glucose + ginsenoside Rd = UDP + ginsenoside Rb1

725570, 725587, 726407

2.4.1.315

2 entries

2.4.1.323

UDP-alpha-D-glucose + 7-deoxyloganetate = UDP + 7-deoxyloganate

726167, 779002

2.4.1.324

UDP-alpha-D-glucose + 7-deoxyloganetin = UDP + 7-deoxyloganin

UDPglucose + 1,2-diacylglycerol = UDP + 3-D-glucosyl-1,2-diacylglycerol

639548, 639549, 639550

UDP-alpha-D-glucose + mogrol = mogroside IE + UDP

746038, 746042

2.4.1.354

UDP-alpha-D-glucose + (R)-mandelonitrile = UDP + (R)-prunasin

UDP-alpha-D-glucose + (20S)-protopanaxadiol = UDP + ginsenoside C-K

UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1

UDP-alpha-D-glucose + (R)-3-(phenyl)lactate = UDP + (R)-(phenyl)lactyl-beta-D-glucose

774742

2.4.1.52

UDPglucose + poly(glycerophosphate) = UDP + alpha-D-glucosyl-poly(glycerol phosphate)

489286

2.4.1.53

UDP-D-glucose + poly(ribitol phosphate) = UDP + glucosyl-poly(ribitol phosphate)

UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine

489371

2.4.1.73

UDP-glucose + lipopolysaccharide = UDP + alpha-D-glucosyl-lipopolysaccharide

489373

2.4.1.78

UDP-glucose + ficaprenol phosphate = UDP + ficaprenolphosphate-glucose

UDP-alpha-D-glucose + archaeol = UDP + 2,3-bis(O-phytanyl)-sn-glycero-1-O-beta-D-glucoside

719709

2.4.1.B51

UDP-alpha-D-glucose + 1,2-diphytanyl-sn-glycero-3-O-beta-D-glucoside = UDP + 1,2-diphytanyl-sn-glycero-3-O-(6-O-beta-D-glucosyl)-beta-D-glucoside

UDP-alpha-D-glucose + alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = UDP + beta-D-glucosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

727043, 727599

2.4.1.B83

UDP-D-glucose + 2,6,6-trimethyl-4-hydroxy-1-carboxaldehyde-1-cyclohexene = UDP + picrocrocin

759858

2.4.1.B88

(R)-3-(phenyl)lactate + UDP-alpha-D-glucose = UDP + (R)-3-(phenyl)lactylglucose

774741

2.4.1.B9

UDP-glucose + D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = UDP + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

UDP-glucose + 20S,24R-ocotillol = UDP + pseudoginsenoside Rt5

UDPglucose + diphosphate = UTP + D-glucose 1-phosphate

645220

2.7.7.64

UDP-monosaccharide + diphosphate = monosaccharide 1-phosphate + UTP

UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol

704249, 704257, 702828, 704251

3.13.1.1

4 entries

3.6.1.45

UDP-glucose + H2O = UMP + alpha-D-glucose 1-phosphate

698591, 696080

3.6.1.9

UDP-glucose + H2O = UMP + D-glucose-1-phosphate

208377, 208391, 246812, 246821, 246828, 208379, 246825, 246830, 246831, 246808

In Vivo Product in Enzyme-catalyzed Reactions (73 results)

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2.4.1.121

UDP + 1-O-(indol-3-yl)acetyl-beta-D-glucose = UDP-glucose + (indol-3-yl)acetate

2.4.1.13

2 entries

2.7.7.10

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose

642821, -

UDP-alpha-D-sulfoquinovopyranose + H2O = UDP-alpha-D-glucose + sulfite

5.1.3.2

32 entries

Substrate in Enzyme-catalyzed Reactions (2016 results)

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1.1.1.136

UDP-D-glucose + NADP+ = ?

UDP-glucose + acceptor = UDP-3-dehydro-D-glucose + reduced acceptor

UDP-glucose + vitexin = UDP + vitexin 2''-O-beta-D-glucoside

UDP-glucose + 2-hydroxycinnamate = UDP + (2E)-3-[2-(beta-D-glucopyranosyloxy)phenyl]prop-2-enoic acid

UDP-glucose + 4-methylumbelliferyl-beta-D-xylopyranoside = ?

702125

2.4.1.135

UDP-glucose + galactosyl-1,3-thiogalactose = ?

UDP-glucose + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + ?

UDPglucose + methylazoxymethanol = UDP + cycasin

488804

2.4.1.172

UDPglucose + salicyl alcohol = UDP + salicin

UDP-glucose + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol

488821

2.4.1.189

UDP-alpha-D-glucose + luteolin = UDP + luteolin 7-O-beta-D-glucoside

488822

2.4.1.191

UDP-glucose + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] = UDP + luteolin 7-O-[beta-D-glucuronosyl-1,2-beta-D-glucuronide]-4'-O-beta-D-glucoside

UDP-glucose + (1,4-alpha-D-glucosyl)n = UDP + (1,4-alpha-D-glucosyl)n+1

UDP-glucose + sn-glycerol 3-phosphate = 2-(beta-D-glucosyl)-sn-glycerol 3-phosphate + UDP

UDP-glucose + vomilenine = UDP + raucaffricine

488935, 488936, 488934, 488937, 488938

2.4.1.22

UDP-glucose + N-acetyl-D-glucosamine = UDP + D-glucosyl(1-4)beta-N-acetyl-D-glucosamine

UDP-glucose + soyasapogenol B = ?

UDP-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + UDP

UDP-D-glucose + 2-deoxystreptamine = UDP + 2'-deamino-2'-hydroxyparomamine

UDP-alpha-D-glucopyranose + methyl alpha-D-mannopyrannoside = UDP + ?

760166

2.4.1.293

714160, 719705, 720888

2.4.1.294

UDP-alpha-D-glucose + cyanidin = UDP + cyanidin 3-O-beta-D-glucoside

UDP-alpha-D-glucose + paromamine = UDP + ?

UDP-alpha-D-glucose + ginsenoside Rd = UDP + ginsenoside Rb1

725570, 725587, 726407

2.4.1.315

5 entries

2.4.1.323

UDP-alpha-D-glucose + 7-deoxyloganetate = UDP + 7-deoxyloganate

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate

675853, 741972, 742432

UDP-alpha-D-glucose + (R)-mandelonitrile = UDP + (R)-prunasin

UDP-alpha-D-glucose + (R)-3-(phenyl)lactate = UDP + (R)-(phenyl)lactyl-beta-D-glucose

774742

2.4.1.47

UDPglucose + 2-(2-hydroxyacyl)sphingosine = glucocerebroside + UDP

UDP-D-glucose + poly(ribitol phosphate) = UDP + glucosyl-poly(ribitol phosphate)

489287

2.4.1.54

UDPglucose + ficaprenyl phosphate = GDP + glucosyl-1-phosphorylficaprenol

UDP-glucose + poly(ribitol phosphate) = UDP + glucosyl-poly(ribitol phosphate)

UDP-glucose + lipopolysaccharide = UDP + alpha-D-glucosyl-lipopolysaccharide

489373

2.4.1.78

UDP-glucose + ficaprenol phosphate = UDP + ficaprenolphosphate-glucose

UDP-alpha-D-glucose + 1,2-diphytanyl-sn-glycero-3-O-beta-D-glucoside = UDP + 1,2-diphytanyl-sn-glycero-3-O-(6-O-beta-D-glucosyl)-beta-D-glucoside

719709

2.4.1.B54

4,4'-diaponeurosporenoate + UDP-alpha-D-glucose = glucosyl 4,4'-diaponeurosporenoate + UDP

UDP-D-glucose + ursodeoxycholate = UDP + 7beta-D-glucosyl-ursodeoxycholate

UDP-D-glucose + 2,6,6-trimethyl-4-hydroxy-1-carboxaldehyde-1-cyclohexene = UDP + picrocrocin

UDP-glucose + alpha-L-Rha-(1->6)-alpha-D-Glc-(1->4)-outer core lipopolysaccharide = beta-D-glucosyl-(1->2)-alpha-L-Rha-(1->6)-alpha-D-Glc-(1->4)-outer core lipopolysaccharide + UDP

767044

2.4.1.B88

(R)-3-(phenyl)lactate + UDP-alpha-D-glucose = UDP + (R)-3-(phenyl)lactylglucose

774741

2.4.1.B9

UDP-glucose + D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = UDP + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

702828, 704257, 704249

UDP-glucose + 20S,24R-ocotillol = UDP + pseudoginsenoside Rt5

UDP-alpha-D-glucose + QEEEGSGGGQGG = UDP + QEEEG-(3-O-(beta-D-glucosyl)-L-serine)-GGGQGG

778841

2.7.1.176

ATP + UDP-alpha-D-glucose = ADP + UDP-alpha-D-glucose 3'-phosphate

761997

2.7.6.4

dATP + UDP-glucose = dAMP + ?

diphosphate + UDP-glucose = UTP + D-glucose 1-phosphate

643065, 643068, 643067, 643058

2.7.7.28

UDPglucose + diphosphate = UTP + D-glucose 1-phosphate

645220

2.7.7.37

UDP-glucose + phosphate = UDP + D-glucose 1-phosphate

UDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + UDP

UDP-N-acetyl-D-glucosamine + UDP-glucose = UMP + ?

UDP-glucose + H2O = ?

666229

3.1.3.12

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate

728601

3.1.4.1

UDP-glucose + H2O = glucose-1-phosphate + 5'-UMP

208393, 208379, 208390

3.1.4.17

UDP-D-glucose + H2O = ?

692369

3.1.4.B4

UDP-alpha-D-glucose + H2O = UDP + D-glucose

727815, 32880, 752306

3.13.1.1

4 entries

3.6.1.1

UDP-glucose + H2O = ?

734503

3.6.1.13

UDP-glucose + H2O = UMP + glucose 5-phosphate

UDP-glucose + H2O = ?

669092

3.6.1.52

UDP-glucose + H2O = ?

UDP-glucose = ?

Product in Enzyme-catalyzed Reactions (189 results)

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2.4.1.121

UDP + 1-O-(indol-3-yl)acetyl-beta-D-glucose = UDP-glucose + (indol-3-yl)acetate

2.4.1.13

3 entries

2.4.1.14

UDP + sucrose 6F-phosphate = UDP-glucose + D-fructose 6-phosphate

2.4.1.144

UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(beta-D-glucosyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP-D-glucose + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

2.4.1.245

alpha,alpha-trehalose + UDP = UDP-alpha-D-glucose + D-glucose

2.7.7.10

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose

642819, 642821, 642817, 642818, 642813, 642816, -

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-alpha-D-glucose

2.7.7.24

20 entries

2.7.7.33

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose

643240, -

2.7.7.44

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-alpha-D-glucose

2.7.7.64

9 entries

2.7.7.83

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-alpha-D-glucose

2.7.7.9

91 entries

3.13.1.1

UDP-alpha-D-sulfoquinovopyranose + H2O = UDP-alpha-D-glucose + sulfite

5.1.3.16

UDP-galactose = UDP-glucose

UDP-alpha-D-galactose = UDP-alpha-D-glucose

1SB9, 3D-view

Activator in Enzyme-catalyzed Reactions (21 results)

activates

32% activation at 2 mM

stimulates

slight stimulation

activates 10% at 5 mM

658670

Inhibitor in Enzyme-catalyzed Reactions (143 results)

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1.1.1.336

0.6 mM, 50% inhibition

692855

1.1.1.374

2 mM, reduces activity by 50%

weak

2 mM, less than 15% inhibition

weak

strong

51% inhibition

1 mM, about 20% inhibition

much lower affinity for OGT compared with UDP-GlcNAc

62.5% decreased activity

661952

2.7.7.10

UDP-galactose pyrophosphorolysis

inhibits uridylyl removing activity

competitive, 70% inhibition

very weak

81% inhibition of the recombinant enzyme at 0.2 mM

65% inhibition at 5 mM

poor inhibitor of UGM

705171

6.3.5.5

1735

3D Structure of Enzyme-Ligand-Complex (PDB) (1111 results)

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (203 results)

0.000247

in 100 mM Tris-HCl pH 8.0, at 30°C

723368

2.4.1.12

2.9

at pH 7.5 and 30°C

758133

2.4.1.121

0.49

pH 7.6, 30°C

in 100 mM cacodylate buffer, pH 7.0 containing 10 mM MnCl2 and 0.2-6 microM purified fusion-beta1,4-GalT7

0.0087

for the cytosolic enzyme

0.29

in 100 mM Tris-HCl (pH 7.6), 10 mM MgCl2, 6 mM 2-mercaptoethanol, and 1 mM phenylmethylsulfonyl fluoride, at 30°C

720518

2.4.1.288

3.4

pH 8.0, 37°C

760166

2.4.1.301

0.053

37°C, pH not specified in the publication

0.13

pH 8.0, 30°C

0.102

at pH 7.4 and 37°C

750726

2.4.1.369

0.16

pH 7.5, 25°C

8.9

pH 7.5, 30°C, cosubstrate: mandelonitrile

0.5

pH 7.5, 25°C

727043

2.4.1.B90

0.00148

pH 7.5, 30°C

0.03

pH and temperature not specified in the publication

778841

2.7.1.176

0.71

pH 6.0, 25°C, recombinant wild-type enzyme ngzeta_1

29.7

at pH 9.5 and 95°C

K_M Value (644 results)

0.0108

pH 7.4, 30°C

0.2

0.19

0.01

reaction with ferulic acid

0.28

in 100 mM cacodylate buffer, pH 7.0 containing 10 mM MnCl2 and 0.2-6 microM purified fusion-beta1,4-GalT7

702125

2.4.1.135

0.233

pH 5.0, 37°C, mutant enzyme H308R

659180

2.4.1.136

2.3

reaction with gallate

recombinant enzyme

2.9

0.04

glucosyltransferase I and II

488624

2.4.1.160

0.67

cosubstrate pyridoxine

0.056

1.58

0.021

0.216

0.11

cosubstrate

2.7

0.065

pH 7.8, 37°C

658786

2.4.1.215

0.11

cisZOG1

0.077

0.8

0.64

pH 7.3, 30°C

654323

2.4.1.240

0.8

pH 7.3, 30°C

apparent value, at pH 5.0, temperature not specified in the publication

6.8

pH 6.5, 70°C

680490

2.4.1.27

0.016

pH 7.9, 25°C

718919

2.4.1.271

0.72

pH 7.1, 40°C

716627

2.4.1.284

0.44

in 100 mM Tris-HCl (pH 7.6), 10 mM MgCl22, 6 mM 2-mercaptoethanol, and 1 mM phenylmethylsulfonyl fluoride, at 30°C

720518

2.4.1.288

0.006

pH 8.0, 37°C

760166

2.4.1.296

0.22

pH 8.3, 30°C

0.26

37°C, pH not specified in the publication, cosubstrate: paromamine

0.32

in 50 mM Tris-HCl buffer, at pH 8.5 and 35°C

0.088

pH 8.0, 30°C

0.045

pH 7.0, 30°C

0.486

at pH 7.4 and 37°C

750726

2.4.1.369

0.013

pH 7.5, 25°C

0.02

pH 8.0, 30°C

0.04

0.12

1.88

0.009

0.12

reaction with apigenin

0.162

pH 7.5, 25°C

0.03135

pH 7.5, 30°C

0.084

pH and temperature not specified in the publication

778841

2.7.1.176

6.4

pH 6.0, 25°C, recombinant wild-type enzyme ngzeta_1

6.3

pH 8.5, 37°C, 5 mM diphosphate

2.535

1.5

pH 8.0, 30°C

0.15

6.09

at pH 9.5 and 95°C

0.09

K_i Value (24 results)

9.4

0.033

4.9

pH 7.0, 37°C, recombinant mutant DELTA39 XylT

0.733

pH 7.6

645378

IC₅₀ Value (2 results)

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2.4.1.255

0.0042

much lower affinity for OGT compared with UDP-GlcNAc

705266

3.1.16.1

0.106

inhibition of degradation of [PO]-d[TCCTCTTTTTTT]

682204

References & Links

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Show Reference (1552 entries)

Ligand UDP-alpha-D-glucose

Basic Ligand Information

Related pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (472 results)

In Vivo Product in Enzyme-catalyzed Reactions (73 results)

Substrate in Enzyme-catalyzed Reactions (2016 results)

Product in Enzyme-catalyzed Reactions (189 results)

Activator in Enzyme-catalyzed Reactions (21 results)

Inhibitor in Enzyme-catalyzed Reactions (143 results)

3D Structure of Enzyme-Ligand-Complex (PDB) (1111 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (203 results)

KM Value (644 results)

Ki Value (24 results)

IC50 Value (2 results)

References & Links

Literature References (1552)

k_cat Value (Turnover Number) (203 results)

K_M Value (644 results)

K_i Value (24 results)

IC₅₀ Value (2 results)