Ligand H2

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Basic Ligand Information

Molecular Structure
Picture of H2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H2
H2
UFHFLCQGNIYNRP-UHFFFAOYSA-N
Synonyms:
deuterium, Hydrogen

Show all pahtways known for Show all pathways known for H2

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + NAD+ + oxidized ferredoxin = H+ + NADH + reduced ferredoxin
show the reaction diagram
-
H2 + ferricytochrome c3 = H+ + ferrocytochrome c3
show the reaction diagram
-
5,10-methenyltetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H+
show the reaction diagram
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H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine
show the reaction diagram
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tetrachloroethene + 2 H2 = cis-1,2-dichloroethene + 2 chloride + 2 H+
show the reaction diagram
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N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2 = coenzyme B + coenzyme M
show the reaction diagram
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H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+
show the reaction diagram
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selenate + H2 = selenite + H2O
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADH + H+ + reduced ferredoxin = H2 + NAD+ + oxidized ferredoxin
show the reaction diagram
-
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12 reduced ferredoxin + 12 H+ + N2 + 40 ATP + 40 H2O = 12 oxidized ferredoxin + 3 H2 + 2 NH3 + 40 ADP + 40 phosphate
show the reaction diagram
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-
CO + H2O = CO2 + H2
show the reaction diagram
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reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (143 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,10-methenyltetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H+
show the reaction diagram
-
H2 + sulfur = H2S
show the reaction diagram
-
2-phenylbutyric acid + H2 = ?
show the reaction diagram
-
acetylene + H2 + ? = ethylene + ?
show the reaction diagram
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H2 + reduced methyl viologen = methyl viologen
show the reaction diagram
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tetrachloroethene + 2 H2 = cis-1,2-dichloroethene + 2 chloride + 2 H+
show the reaction diagram
-
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2 = coenzyme B + coenzyme M
show the reaction diagram
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reduced N,N,N',N'-tetramethyl-4-phenylenediamine + O2 + H2 = oxidized N,N,N',N'-tetramethyl-4-phenylenediamine + H2O
show the reaction diagram
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selenate + H2 = selenite + H2O
show the reaction diagram
-
phosphatidylcholine + H2 = 1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
H2 + CO2 + CH3-H4SPt + CoASH = acetyl-CoA + H4SPt + H2O
show the reaction diagram
-
3'-phosphoadenosine 5'-phosphate + H2 = AMP + phosphate
show the reaction diagram
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urokinase-type plasminogen activator receptor + H2 = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (54 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-malate + NAD+ = acetate + CO2 + H2 + NADH
show the reaction diagram
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2 Mn2+ + 2 H+ = 2 Mn3+ + H2
show the reaction diagram
-
-
formate = H2 + CO2
show the reaction diagram
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17alpha-hydroxypregnenolone + [reduced NADPH-hemoprotein reductase] + O2 = 3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH-hemoprotein reductase] + H2
show the reaction diagram
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NADPH + 3 H+ + 2 reduced ferredoxin [iron-sulfur] cluster = H2 + NADP+ + 2 oxidized ferredoxin [iron-sulfur] cluster
show the reaction diagram
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coenzyme B + coenzyme M + reduced ferredoxin + H+ + coenzyme F420 = coenzyme B-coenzyme M disulfide + ferredoxin + H2 + reduced coenzyme F420
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
suggested to be involved in the activation of the methylreductase, preincubation
-
stimulates
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits formation of N5,N10-methenyltetrahydromethanopterin
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inhibits hydrogen production
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CO-reduction by V-nitrogenase is inhibited by the addition of increasing amounts of H2
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inhibits both N2 and diazene reduction
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (39 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
-999
-
apparent Km value for H2 is about 6% in the gas phase, pH 7.5, 45°C
0.03
-
pH 7, 65°C, H2: heterodisulfide oxidoreductase complex

References & Links

Links to other databases for H2

ChEBI
PubChem
ChEBI
PubChem