Ligand lactosylceramide

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Basic Ligand Information

Molecular Structure
Picture of lactosylceramide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C34H62NO13R
lactosylceramide
JZWZSTXXMJPBLC-SQUNGEPOSA-N
Synonyms:
beta-D-galactosyl-(1,4)-D-glucosylceramide, beta-D-galactosyl-(1-4)-beta-D-glucosyl-(1-1)-ceramide, beta-D-galactosyl-(1-4)-D-glucosylceramide, beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide, beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide, beta-D-galactosyl-(1->4)-D-glucosylceramide, beta-D-galactosyl-1,4-beta-D-glucosylceramide, D-galactosyl-1,4-beta-D-glucosylceramide, Gal-beta-1,4-Glc-beta-1,1-Cer, lactosyl-ceramide, lactosyl-N-acylsphingosine, lactosyl ceramide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-N-acetyl-D-glucosamine + lactosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
show the reaction diagram
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lactosyl-ceramide + H2O = ?
show the reaction diagram
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lactosylceramide + H2O = beta-D-glucose + galactosylceramide
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-galactose + lactosylceramide = ?
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UDP-galactose + lactosylceramide = ?
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GDP-L-fucose + lactosylceramide = GDP + ?
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CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
show the reaction diagram
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lactosylceramide + 3'-phosphoadenylylsulfate = lactosylceramide sulfate + adenosine 3',5'-bisphosphate
show the reaction diagram
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lactosylceramide + H2O = ?
show the reaction diagram
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lactosyl-ceramide + H2O = ?
show the reaction diagram
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lactosyl ceramide + H2O = ?
show the reaction diagram
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lactosylceramide + H2O = beta-D-glucose + galactosylceramide
show the reaction diagram
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lactosylceramide + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose
show the reaction diagram
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asialo GM2 ganglioside + H2O = lactosylceramide
show the reaction diagram
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GalNAc-beta-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer = GalNAc + Gal-beta-1,4-Glc-beta-1,1-Cer
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits reaction with GM1a
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (25 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.5
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0.021
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cerebellum microsomes
5.88
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0.27
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References & Links

Links to other databases for lactosylceramide

ChEBI
PubChem
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PubChem