Ligand D-glucuronate

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Basic Ligand Information

Molecular Structure
Picture of D-glucuronate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10O7
D-glucuronate
IAJILQKETJEXLJ-QTBDOELSSA-N
Synonyms:
D-glucuronic acid, glucuronate, glucuronic acid


Show all pahtways known for Show all BRENDA pathways known for D-glucuronate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucuronic acid = L-iduronic acid
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-gulonate + NADP+ = D-glucuronate + NADPH
show the reaction diagram
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L-gulonic acid + NADP+ = D-glucuronic acid + NADPH
show the reaction diagram
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1,2-linked glucuronic acid of non-reducing xylose-oligosaccahrides + H2O = D-glucuronic acid + ?
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baicalin + H2O = baicalein + D-glucuronate
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3-D-glucuronosyl-N2,6-disulfo-beta-D-glucosamine + H2O = D-glucuronate + N2,6-disulfo-D-glucosamine
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Substrate in Enzyme-catalyzed Reactions (40 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucuronic acid + NADPH = ?
show the reaction diagram
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D-glucuronic acid + NADPH = L-gulonic acid + NADP+
show the reaction diagram
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glucuronic acid + NADPH = ? + NADP+
show the reaction diagram
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D-glucuronic acid + NADPH = ? + NADP+
show the reaction diagram
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D-glucuronate + NADH = L-gulonate + NAD+
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D-glucuronate + NADP+ = ?
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D-glucuronate + NADP+ = D-glucurono-1,5-lactone + NADPH
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alpha-D-glucose 1-phosphate + D-glucuronic acid = 3-O-beta-D-glucopyranosyl-D-glucuronic acid + phosphate
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D-Glucuronate = ?
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D-Glucuronate = ?
show the reaction diagram
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D-glucuronic acid = L-iduronic acid
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (120 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-gulonate + NADP+ = D-glucuronate + NADPH
show the reaction diagram
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D-glucose + NAD+ + H2O = D-glucuronic acid + NADH
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D-glucurono-6,2-lactone + H2O = D-glucuronic acid
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mycophenolic acid O-acyl-glucuronide + H2O = mycophenolic acid + D-glucuronate
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glucuronate 6-phosphate + H2O = glucuronate + phosphate
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glucuronic acid 6-sulfate + H2O = glucuronic acid + sulfate
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hyaluronan + H2O = N-acetyl-beta-D-glucosamine + D-glucuronate
show the reaction diagram
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hyaluronan + H2O = N-acetyl-beta-D-glucosamine + D-glucuronate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
65% activation at 3 mM
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5 mM, 1.25fold activation
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Inhibitor in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
high concentrations, inhibition in a non-competitive manner
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reduced, noncompetitive
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0.1 mg/ml, 14% inhibition
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10 mM, 15% inhibition
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5 mM, 98% inhibition
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slight inhibition at 10 mM
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competitive
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1 mM, 38% inhibition
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (17 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (34 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
11.6
-
-
8.3
-
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KM Value (100 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.465
-
-
6
-
L-iduronic acid
186
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Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
7.5
-
IC50: 7.5 mM, competitive

References & Links

Links to other databases for D-glucuronate

ChEBI
PubChem
ChEBI
PubChem