Ligand mercury(2+)

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Basic Ligand Information

Molecular Structure
Picture of mercury(2+) (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Hg
mercury(2+)
BQPIGGFYSBELGY-UHFFFAOYSA-N
Synonyms:
cationic mercury, Hg2+


Show all pahtways known for Show all BRENDA pathways known for mercury(2+)

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + Hg2+/in = ADP + phosphate + Hg2+/out
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (77 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + Hg2+/in = ADP + phosphate + Hg2+/out
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
mercury chloride, and methylmercury, activates PLD, the stimulation is regulated by Ca2+ and calmodulin, mechanism, overview. Calcium chelating agents and calcium depletion, e.g. by EGTA, calmodulin inhibitors, e.g. calmidazolium chloride and trifluoperazine, and L-type calcium channel blockers nifedipine, nimodipine, and diltiazem attenuate the stimulation of PLD by mercury, overview
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enhances the activity of the enzyme
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Inhibitor in Enzyme-catalyzed Reactions (3044 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
complete inhibition at 1 mM
-
0.005 mM, complete inhibition, prevented by 10 mM glutathione
-
40% inhibition of NAD dehydrogenase II at 0.004 mM
-
53% inhibition at 0.002 mM
-
IC50 0.00009 mM
-
irreversible inactivation
-
complete inhibition at 2 mM
-
strong inhibition
-
nearly complete inhibition at 2 mM
-
complete inhibition at 1 mM
-
complete inhibition at 1 mM
-
99% inactivation at 1 mM
-
almost complete inhibition at 0.25 mM
-
almost complete inhibition at 0.25 mM
-
complete inhibition
-
slight inhibition
-
strong inhibitor
-
1 mM, less than 10% residual activity
-
0.1 mM, complete inhibition
-
strong
-
inhibition at 1 mM, and destabilization at 10 mM
-
2 mM, complete inactivation
-
complete inhibition at 0.1 mM
-
0.001 mM, 2 min, complete inhibition
-
complete inhibition at 1 mM
-
completely inhibits reduction of 2-dehydropantolactone
-
0.0005 mM, almost complete inhibition
-
100% inhibition at 5 mM; 5 mM, 100% inhibition
-
0.1 mM, complete inhibition
-
67% inhibition at 1 mM
-
1 mM, complete inhibition
-
strong inhibition at 1 mM
-
strong inhibitor
-
0.1 mM HgCl2 complete inhibition
-
1 mM, 93% inhibition
-
22% inhibition at 2 mM
-
0.1 mM concentration 98% inhibition
-
60% inhibition at 1 mM
-
1 mM, complete inhibition
-
2% residual activity at 1 mM
-
2 mM, 20% inhibition after 6 h
100% inhibition at 1 mM
-
strong
-
100% inhibition at 0.1 mM
-
1 mM, 84% inhibition
-
0.01 mM, appreciable inhibition
-
21% inhibition at 0.01 mM
-
complete inhibition at 1 mM
-
complete inhibition at 1 mM
-
inhibition of NADH oxidizing activity
-
10 mM, 14% residual activity
-
complete inhibition at 1 mM
-
inhibits Oep1LOX2 by 60% and totally inactivates Oep2LOX2
-
complete inhibition at 1 mM
-
0.1 mM, 45% inhibition
-
1 mM, complete inhibition
-
strong inhibition
-
inhibition reversed by glutathione
-
blocks cysteines in the active site pocket
1 mM, 87% loss of activity
-
0.4 mM, 96% inhibition
-
0.5 mM, strong
-
causes a 20-30% fall in activity
-
50% inhibition at 0.005 mM
-
1 mM, 98% inhibition
-
0.01-0.1 mM, 96% loss of activity
-
1 mM, about 5% residual activity
-
0.1 mM HgCl2, complete inhibition
-
0.1 mM, 87% inhibition
-
complete inhibition at 0.01 mM
-
complete inhibition at 0.1 mM
-
63% inhibition at 1 mM, crude enzyme extract
-
complete inhibition at 5 mM
-
severely inhibits enzyme activity
-
0.1 mM concentration, 100% inhibition
-
97% inhibition at 0.5 mM
-
0.0001 mM, 56% inhibition
-
slight inhibition
-
DELTA12-desaturase system, enzymatic complex
-
0.4 mM, 96% inhibition
-
complete inhibition at 1 mM, mitochondrial enzyme
-
0.77% residual activity at 1.0 mM
-
complete inhibition of hypoxanthine oxidation at 0.1 mM
-
95% inhibition at 1 mM
-
62% inhibition at 1 mM
-
almost complete inhibition at 1 mM HgCl2
-
complete inhibition at 1 mM
-
77% inhibition in the presence of 1 mM
-
complete inhibition at 2 mM
-
1 mM causes complete inhibition
-
1 mM, 17.5% inhibition
-
complete inhibition at 1 mM
-
both isoforms
-
1 mM, 12 h, 4°C, 99% loss of activity
-
1 mM, complete inhibition
-
mM concentration
-
strong inhibitor, 4% residual activity at 2 mM Hg2+
-
complete inhibition at 2 mM
-
complete inhibition of both orotate reductase and NADH oxidase reaction
-
1 mM, 86% inhibition
-
0.1 mM, 92% inhibition
-
complete inhibition at 1 mM
-
1 mM, 97% inhibition
-
completely inhibits at 0.1 mM
-
1 mM, 61% inhibition of the recombinant enzyme
-
inactivation due to dissociation of FAD from the enzyme molecule and denaturation of the apoenzyme
-
complete inhibition at 10 mM
-
2.0 mM
-
complete inhibition at 1 mM (pH 7.0)
-
almost total inhibition at 0.1 mM
-
0.13 mM, complete inhibition
-
strong inhibition at 1 mM Hg2+
-
89% inhibition at 1 mM
-
1 mM, about 80% inhibition
-
strong inhibition at 1 mM
-
1 mM
-
96% inhibition at 0.1 mM
-
complete inhibition at 0.1 mg/ml
-
0.1 mM, complete inhibition
-
0.5 mM, complete inhibition
-
about 70% inhibition
-
about 70% inhibition
-
80% inhibition at 1 mM
-
inhibitory
-
relative activity less than 5%
-
strong inhibition
-
1 mM shows strong inhibitory effect on recombinant rBfmBC activity (more than 80% inhibition)
-
0.01 mM, 100% inhibition
-
cytochrome c oxidase activities of strains AP19-3 and ATCC 23270 are completely inhibited by 0.001 mM and 0.005 mM. Strain MON-1 is inhibited 33% by 0.005 mM, and 70% by 0.010 mM
-
complete inhibition at 1 mM
-
complete inhibition
-
0.1 mM, complete inhibition
-
5 mM, complete inhibition
-
0.1 mM, 96% inhibition
-
5 mM, complete inhibition
-
0.1 mM, strong inhibition
-
0.1 mM, no resiudal activity
-
0.01 M, strong
-
complete inhibition at 1 mM
-
relative activity 0% of control
-
100% inhibition at 0.05 mM
-
0.1 mM, 43% residual activity
-
complete inhibition
-
0.1 mM, 65% inhibition
-
0.1 mM, complete inhibition
-
0.00001 mM, 50% inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
-
complete inhibition at 0.1 mM
-
0.01 mM, complete inhibition
-
strong
-
strong inhibition
-
; 11% remaining activity isoenzyme Nat-b; 36% remaining activity isoenzyme NAT-a
-
noncompetitive with respect to choline, IC50: 0.0004 mM, mixed type inhibition with respect to acetyl-CoA, IC50: 0.0025 mM, activity can be recovered using 2,3-dimercapto-propanol
-
complete inhibition
-
19.8% residual activity after 1 h at 1 mM
-
5 mM, complete inhibition
-
95% inhibition at 2 mM
-
complete inactivation
-
1 mM
-
0.1 mM, residual activity 26%
-
strongly inhibits the sterol glucosyltransferase activity, IC50 (mM): 0.5
-
enzyme activity is completely inhibited by 0.1 mM Hg2+
-
at 1 mM
-
1 mM, 33% inhibition
-
10 mM, complete inhibition, reversed by addition of 20 mM 2-mercaptoethanol
-
complete inhibition at 10 mM
-
1 mM, 99% inhibition with quercetin as substrate
-
1 mM, 55% residual acitvity
-
0.1 mM, complete inhibition. The observed enzyme inhibition by Cu2+ and Hg2+ may not solely be attributed to their effects on the enzyme itself because these heavy metal ions are known to destroy substrate anthocyanins
-
complete inhibition at 5 mM
-
slight inhibition at 1 mM
-
10 mM, complete inhibition
-
1 mM, 50°C, 30 min, abolishes the phosphorolytic activity almost completely
-
1 mM, strong
-
97% inhibition at 1 mM
-
complete inhibition at 3 mM after 3 min at 0°C
-
complete inhibition at 0.1 mM
-
complete inhibition at 1 mM
-
strongly inhibites both O-acetyl-L-serine sulfhydrylation and O-phospho-L-serine sulfhydrylation
-
weak
-
1 mM, 0% residual activity
-
strong inhibition, reducing agent reverses
-
strong
-
0.002 mM, 50% inhibition in the presence of 3 mM Mg2+
-
0.01 mM, 25% inhibition, 0.1 mM, almost complete inhibition
-
55% inhibition at 1 mM
-
at PO2 of about 20 mM
-
0.1 mM, complete inhibition
-
0.083 mM, 76% inhibition
-
strong inhibition
-
partially reversed by dithiothreitol
-
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
-
1 mM, almost complete inhibition
-
10 mM, complete inhibition
-
50% inhibition at 0.001 mM
-
30% residual activity at 1 mM
-
2.1% residual activity at 1 mM
-
0.1 mM, complete inhibition
-
5 mM
-
6% remaining activity after 5 min, 1 mM
-
9% relative residual activity
-
complete inhibition at 1 mM
-
1 mM, 58% inhibition
-
no activity at 1 mM HgCl2
-
with RNA core as substrate
-
susceptible to inhibition by Hg2+
-
50% inhibition at 0.0006 mM, inhibition of both DNA glycosylase and apurinic nicking activities, binding capability not reduced
-
; 0.1 mM, no residual activity
-
competitive towards Mg2+
-
competitive
-
reduces activity by 30-40%
-
strong
-
strong inhibition at 1 mM
-
1 mM, complete inhibition
-
potent inhibitor, inhibition reversed by adding an excess of dithiothreitol
-
strong
-
1.33 mM, 1.2% relative activity
-
strong, with p-nitrophenyl-beta-D-glucopyranoside as substrate
-
98% inhibition at 1 mM
-
1 mM, almost complete inhibition
-
strong
-
1 mM, 80% inhibition
-
inhibits activity at 1 mM, 6% relative activity compared with activity without any addition of effector
-
1 mM complete loss of activity
-
1 mM, 77% inhibition
-
1 mM, 88% loss of activity
-
complete inhibition at 1 mM
-
10 mM, significant inhibition
-
10 mM, complete inhibition
-
1 mM, no residual activtiy
-
5 mM, 25% loss of activity
-
no activity is detected after 1 h of incubation at 1mM Hg2+
-
1 mM, 3% of initial activity
-
complete inhibition at 5 mM
-
noncompetitive
-
5 mM, strong inhibition
-
5 mM complete inactivation
-
more than 90% inhibition
-