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Ligand guanosine

Basic Ligand Information

Molecular Structure

Related pathways

Pathway Source

Pathways

BRENDA

purine metabolism

KEGG

ABC transporters, Nucleotide metabolism, Purine metabolism

MetaCyc

guanine and guanosine salvage I, guanine and guanosine salvage II, guanine and guanosine salvage III, guanosine nucleotides degradation I, guanosine nucleotides degradation II, guanosine nucleotides degradation III, nucleoside and nucleotide degradation (archaea), purine ribonucleosides degradation more

Show all BRENDA pathways known for guanosine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (15 results)

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Show Natural Substrate (15 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.39

guanosine + 2 O2 + H2O = 9-riburonosylguanine + 2 H2O2

287628

-

2.4.2.1

guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate

736556, 759810, 760019, 758797, 759175, 759339, 759341, 760069, 759101, 758600

1RFG, 3D-view

2.4.2.1

guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate

736556, 759810, 760019, 758797, 759175, 759339, 759341, 760069, 759101, 758600

3IEX, 3D-view

2.4.2.15

guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate

766513

-

2.4.2.15

guanosine + phosphate = guanine + D-ribose 1-phosphate

489774

-

2.4.2.1

2 entries

2.4.2.15

2 entries

2.4.2.22

guanosine + 5-phospho-alpha-D-ribose 1-diphosphate = GMP + diphosphate

759601

-

2.4.2.28

guanosine + phosphate = guanine + D-ribose 1-phosphate

637544

1JE1, 3D-view

2.4.2.28

guanosine + phosphate = guanine + D-ribose 1-phosphate

637544

1ODJ, 3D-view

2.4.2.28

2 entries

2.4.2.8

guanosine + 5-phospho-alpha-D-ribose 1-diphosphate = GMP + diphosphate

758563, 758804, 758862, 759601, 759221, 759254, 759769, 759433

-

2.7.1.143

diphosphate + guanosine = phosphate + GMP

656748

-

2.7.1.73

ATP + guanosine = ADP + GMP

721378, 723803

6VWO, 3D-view

2.7.1.73

ATP + guanosine = ADP + GMP

721378, 723803

6VWP, 3D-view

2.7.1.73

2 entries

3.2.2.1

guanosine + H2O = D-ribose + guanine

714225

-

3.5.4.15

guanosine + H2O = xanthosine + NH3

209538, 209536, 209537, 734892, 751844, 757819, 777020, 777117, 778693

7DC9, 3D-view

3.5.4.15

guanosine + H2O = xanthosine + NH3

209538, 209536, 209537, 734892, 751844, 757819, 777020, 777117, 778693

7DQN, 3D-view

3.5.4.15

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

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Show Natural Product (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.1

guanine + alpha-D-ribose 1-phosphate = guanosine + phosphate

-

1RFG, 3D-view

2.4.2.1

guanine + alpha-D-ribose 1-phosphate = guanosine + phosphate

-

3IEX, 3D-view

3.1.3.5

5'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.5

GMP + H2O = guanosine + phosphate

-

-

2.4.2.1

2 entries

3.1.3.5

2 entries

Substrate in Enzyme-catalyzed Reactions (66 results)

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Show Substrate (66 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.28

guanosine + O2 = 9-riburonosylguanine + H2O

287612

-

1.1.3.39

guanosine + 2 O2 + H2O = 9-riburonosylguanine + 2 H2O2

287628

-

1.11.1.10

guanosine + Br- + H2O2 = 8-bromoguanosine + H2O

348310

-

2.4.2.1

guanosine + arsenate = guanine + alpha-D-ribose 1-arsenate

489688

1RFG, 3D-view

2.4.2.1

guanosine + arsenate = guanine + alpha-D-ribose 1-arsenate

489688

3IEX, 3D-view

2.4.2.1

guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate

489699, 489652, 489654, 489665, 489711, 489680, 489693, 489658, 489707, 489678, 489682, 489687, 489708, 489660, 489676, 489692, 489670, 489675, 489690, 489667, 489703, 489661, 489672, 489688, 489698, 489673, 489669, 489671, 489662, 489679, 662616, 662643, 672266, 673591, 674629, 673191, 675607, 686625, 685103, 703607, 704899, 705855, 701476, 701915, 702230, 721902, 722135, 721355, 721810, 721756, 721842, 726781, 734059, 736556, 736075, 736246, 737138, 737172, 735691, 759810, 760019, 758797, 759175, 759339, 759341, 760069, 759101, 758600, 777273, 778053, 779228

1RFG, 3D-view

2.4.2.1

guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate

489699, 489652, 489654, 489665, 489711, 489680, 489693, 489658, 489707, 489678, 489682, 489687, 489708, 489660, 489676, 489692, 489670, 489675, 489690, 489667, 489703, 489661, 489672, 489688, 489698, 489673, 489669, 489671, 489662, 489679, 662616, 662643, 672266, 673591, 674629, 673191, 675607, 686625, 685103, 703607, 704899, 705855, 701476, 701915, 702230, 721902, 722135, 721355, 721810, 721756, 721842, 726781, 734059, 736556, 736075, 736246, 737138, 737172, 735691, 759810, 760019, 758797, 759175, 759339, 759341, 760069, 759101, 758600, 777273, 778053, 779228

3IEX, 3D-view

2.4.2.15

guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate

766513

-

2.4.2.15

guanosine + phosphate = guanine + D-ribose 1-phosphate

489774, 489775

-

2.4.2.1

4 entries

2.4.2.15

2 entries

2.4.2.22

guanosine + 5-phospho-alpha-D-ribose 1-diphosphate = GMP + diphosphate

759601

-

2.4.2.28

guanosine + phosphate = guanine + D-ribose 1-phosphate

637556, 637544, 658681

1JE1, 3D-view

2.4.2.28

guanosine + phosphate = guanine + D-ribose 1-phosphate

637556, 637544, 658681

1ODJ, 3D-view

2.4.2.28

2 entries

2.4.2.3

guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate

705176

-

2.4.2.5

guanosine + 2,6-diaminopurine = guanine + 2,6-diaminopurine ribonucleoside

759220

-

2.4.2.5

guanosine + 2-chloroadenine = guanine + 2-chloroadenosine

759220

-

2.4.2.5

guanosine + 2-fluoroadenine = guanine + 2-fluoroadenosine

759220

-

2.4.2.5

guanosine + 6-methoxyguanine = guanine + 6-methoxyguanosine

759220

-

2.4.2.5

guanosine + adenine = guanine + adenosine

759220

-

2.4.2.5

guanosine + hypoxanthine = guanine + inosine

759220

-

2.4.2.5

6 entries

2.4.2.6

2'-deoxyadenosine + guanosine = 2'-deoxyguanosine + adenosine

776299

-

2.4.2.8

guanosine + 5-phospho-alpha-D-ribose 1-diphosphate = GMP + diphosphate

758563, 758804, 758862, 759601, 759221, 759254, 759769, 759433

-

2.7.1.113

ATP + guanosine = ADP + GMP

640550, 640561

-

2.7.1.113

GTP + guanosine = GDP + guanosine 5'-phosphate

640561

-

2.7.1.113

2 entries

2.7.1.114

AMP + guanosine = adenosine + guanosine 5'-phosphate

640570

-

2.7.1.143

diphosphate + guanosine = monophosphate + GMP

645029, 645031

-

2.7.1.143

diphosphate + guanosine = phosphate + GMP

656748

-

2.7.1.145

ATP + guanosine = ADP + guanosine 5'-phosphate

737404

-

2.7.1.145

guanosine + ATP = guanosine 5'-phosphate + ADP

636842, 636844

-

2.7.1.143

2 entries

2.7.1.145

2 entries

2.7.1.20

ATP + guanosine = ?

641115

-

2.7.1.21

ATP + guanosine = ADP + GMP

722671

-

2.7.1.73

ATP + guanosine = ADP + GMP

641925, 641923, 721378, 723803, 734059

6VWO, 3D-view

2.7.1.73

ATP + guanosine = ADP + GMP

641925, 641923, 721378, 723803, 734059

6VWP, 3D-view

2.7.1.73

dATP + guanosine = dADP + GMP

641925

6VWO, 3D-view

2.7.1.73

dATP + guanosine = dADP + GMP

641925

6VWP, 3D-view

2.7.1.73

UTP + guanosine = UDP + GMP

641925

6VWO, 3D-view

2.7.1.73

UTP + guanosine = UDP + GMP

641925

6VWP, 3D-view

2.7.1.76

ATP + guanosine = ADP + GMP

675428

-

2.7.1.76

ATP + guanosine = ADP + guanosine 5'-monophosphate

675428

-

2.7.1.77

3'-AMP + guanosine = GMP + adenosine

642001, 641994

-

2.7.1.77

4-nitrophenyl phosphate + guanosine = 4-nitrophenol + GMP

642003

-

2.7.1.77

5'-AMP + guanosine = GMP + adenosine

642001

-

2.7.1.77

5'-CMP + guanosine = GMP + cytidine

642001

-

2.7.1.77

5'-IMP + guanosine = GMP + inosine

642001

-

2.7.1.77

5'-UMP + guanosine = GMP + uridine

642001

-

2.7.1.77

diphosphate + guanosine = phosphate + 5'-GMP

642002

-

2.7.1.77

phenyl phosphate + guanosine = GMP + phenol

641990, 641991

-

2.7.1.B20

ATP + guanosine = ADP + GMP

727430

-

2.7.1.B20

ATP + guanosine = ADP + guanosine 5'-phosphate

728780, 697882

-

2.7.1.B20

GTP + guanosine = GDP + GMP

727430

-

2.7.1.B20

GTP + guanosine = GDP + guanosine 5'-phosphate

728780

-

2.7.1.B20

ITP + guanosine = IDP + GMP

727430

-

2.7.1.B20

ITP + guanosine = IDP + guanosine 5'-phosphate

728780

-

2.7.1.73

6 entries

2.7.1.76

2 entries

2.7.1.77

8 entries

2.7.1.B20

6 entries

2.7.7.19

ATP + guanosine = diphosphate + ?

642991

-

2.7.7.84

3 guanosine = ?

721571

-

3.2.2.1

guanosine + H2O = D-ribose + guanine

326377, 326387, 326380, 326379, 326388, 137116, 326392, 326389, 326385, 326386, 326370, 655726, 669883, 667792, 670166, 683854, 698781, 700035, 695873, 714225, 707171, 716358, 750094, 752135, 771270, 774973, 775534, 768397, 769229, 752110

-

3.2.2.1

guanosine + H2O = guanine + D-ribose

654127, 654255, 656488, 696726, 731054

-

3.2.2.2

guanosine + H2O = D-ribose + guanine

713705

-

3.2.2.2

guanosine + H2O = guanine + D-ribose

137050, 137052, 137051, 683973, 695873, 700035

-

3.2.2.7

guanosine + H2O = 2-amino-1,9-dihydropurine-6-on + D-ribofuranose

137099

-

3.2.2.7

guanosine + H2O = guanine + D-ribose

752110

-

3.2.2.1

2 entries

3.2.2.2

2 entries

3.2.2.7

2 entries

3.2.2.8

guanosine + H2O = guanine + D-ribose

137117, 664140, 752168

-

3.5.4.15

guanosine + H2O = xanthosine + NH3

209538, 209536, 209537, 209539, 734892, 751844, 757819, 777020, 777117, 778693

7DC9, 3D-view

3.5.4.15

guanosine + H2O = xanthosine + NH3

209538, 209536, 209537, 209539, 734892, 751844, 757819, 777020, 777117, 778693

7DQN, 3D-view

3.5.4.3

guanosine + H2O = ?

712380, 734510

-

3.5.4.3

guanosine + H2O = xanthosine + NH3

209585

-

3.5.4.15

2 entries

3.5.4.3

2 entries

3.5.4.4

guanosine + H2O = xanthosine + NH3

686612, 770010

2QVN, 3D-view

Product in Enzyme-catalyzed Reactions (52 results)

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Show Product (52 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.1

guanine + alpha-D-ribose 1-phosphate = guanosine + phosphate

-

1RFG, 3D-view

2.4.2.1

guanine + alpha-D-ribose 1-phosphate = guanosine + phosphate

-

3IEX, 3D-view

2.4.2.1

guanine + ribose 1-phosphate = guanosine + phosphate

489677

1RFG, 3D-view

2.4.2.1

guanine + ribose 1-phosphate = guanosine + phosphate

489677

3IEX, 3D-view

2.4.2.5

guanine + inosine = guanosine + hypoxanthine

639646, -

-

2.4.2.5

guanine + uridine = guanosine + uracil

639646

-

2.4.2.1

4 entries

2.4.2.5

2 entries

2.4.2.6

2'-deoxyguanosine + adenosine = 2'-deoxyadenosine + guanosine

-

-

2.7.1.77

5'-GMP + adenosine = AMP + guanosine

-

-

2.7.1.77

5'-GMP + cytidine = CMP + guanosine

-

-

2.7.1.77

5'-GMP + inosine = IMP + guanosine

-

-

2.7.1.77

5'-GMP + thymidine = TMP + guanosine

-

-

2.7.1.77

5'-GMP + uridine = UMP + guanosine

-

-

2.7.1.77

5 entries

3.1.13.3

5'-phosphoguanylyl-(3',5')-guanosine + H2O = GMP + guanosine

-

-

3.1.26.1

GpA + H2O = 5'-AMP + guanosine

-

-

3.1.26.1

GpC + H2O = 5'-CMP + guanosine

-

-

3.1.26.1

GpG + H2O = 5'-GMP + guanosine

-

-

3.1.26.1

GpU + H2O = 5'-UMP + guanosine

-

-

3.1.3.1

2'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.1

3'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.1

5'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.1

GMP + H2O = guanosine + phosphate

-

-

3.1.26.1

4 entries

3.1.3.1

4 entries

3.1.3.104

GMP + H2O = guanosine + phosphate

-

-

3.1.3.2

3'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.2

5'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.2

GMP + H2O = guanosine + phosphate

-

-

3.1.3.2

guanosine monophosphate + H2O = guanosine + phosphate

-

-

3.1.3.25

2'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.25

3'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.25

5'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.5

5'-GMP + H2O = guanosine + phosphate

95032, 95046, 95053, 95052, 95035, 95064, 95045, 95056, 95068, 95047, 95026, 95039, 649751, 95058, 95051, 95027, 95031, 95054, 95059, 95060, 95044, 95034, 95074, 95038, 95065, 95021, 95042, 95055, 95067, 95033, 95028, 95025, 95037, 95063, 652095, 650886, 653772, -

-

3.1.3.5

5'-GMP + xanthosine = XMP + guanosine

-

-

3.1.3.5

GMP + H2O = guanosine + phosphate

-

-

3.1.3.6

3'-GMP + H2O = guanosine + phosphate

95084, 95082, 95091, 95093, 95077, 95079, 95087, 95089, 95088, 95075

-

3.1.3.6

5'-GMP + H2O = guanosine + phosphate

-

-

3.1.3.2

4 entries

3.1.3.25

3 entries

3.1.3.5

3 entries

3.1.3.6

2 entries

3.1.3.89

GMP + H2O = guanosine + phosphate

-

-

3.1.30.1

3'-GMP + H2O = guanosine + phosphate

134971, 134970, 134972, 134975

-

3.1.4.16

3'-GMP + H2O = guanosine + phosphate

-

-

3.1.4.52

5'-phosphoguanylyl(3'-5')guanosine + H2O = guanosine 5'-monophosphate + guanosine

-

-

3.1.4.52

5'-phosphoguanylyl(3'->5')guanosine + H2O = GMP + guanosine

-

-

3.1.4.52

2 entries

3.1.5.1

GTP + H2O = guanosine + triphosphate

135502, -

-

3.5.4.4

2,6-diaminopurine riboside + H2O = guanosine + NH3

-

2QVN, 3D-view

3.5.4.4

2-amino-6-chloropurine riboside + H2O = guanosine + ?

-

2QVN, 3D-view

3.5.4.4

2-amino-6-chloropurine riboside + H2O = guanosine + Cl-

209609

2QVN, 3D-view

3.5.4.4

2-amino-6-methoxypurine riboside + H2O = guanosine + ?

-

2QVN, 3D-view

3.5.4.4

4 entries

3.6.1.11

5'-GMP + H2O = guanosine + phosphate

-

-

4.6.1.18

CpG + H2O = guanosine + 3'-CMP

-

-

4.6.1.18

UpG + H2O = guanosine + 3'-UMP

-

-

4.6.1.19

ApG + H2O = AMP + guanosine

-

-

4.6.1.19

CpG + H2O = CMP + guanosine

-

-

4.6.1.19

GpG + H2O = GMP + guanosine

-

-

4.6.1.19

UpG + H2O = UMP + guanosine

-

-

4.6.1.18

2 entries

4.6.1.19

4 entries

4.6.1.24

GpG + H2O = guanosine 3'-phosphate + guanosine

-

-

Activator in Enzyme-catalyzed Reactions (5 results)

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Show Activating Compound (5 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.4.22

lower affinity or extent of activation than GTP

663997

-

3.1.3.2

1 mM, activity: 299%, isoenzyme 2

691171

-

3.1.3.2

activates enzyme form B but not enzyme form A

134717

-

3.1.3.2

2 entries

3.1.4.16

2',3'-cyclic nucleotide phosphodiesterase activity

135201

-

4.3.1.1

activation to 120-130%, allosteric

651820

-

Inhibitor in Enzyme-catalyzed Reactions (46 results)

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Show Inhibitors (46 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.132

slight inhibition only after preincubation with enzyme

285839

-

1.1.1.17

10% inhibition of fructose 6-phosphate reduction

389423

-

2.4.1.1

-

488234

-

2.4.1.69

slight

489355

-

2.4.2.1

-

489682

1RFG, 3D-view

2.4.2.1

-

489682

3IEX, 3D-view

2.4.2.1

inhibits phosphorolysis of xynthosine

489707

1RFG, 3D-view

2.4.2.1

inhibits phosphorolysis of xynthosine

489707

3IEX, 3D-view

2.4.2.1

product inhibition

489658

1RFG, 3D-view

2.4.2.1

product inhibition

489658

3IEX, 3D-view

2.4.2.1

strong competitive inhibitor with deoxyinosine as substrate

489661

1RFG, 3D-view

2.4.2.1

strong competitive inhibitor with deoxyinosine as substrate

489661

3IEX, 3D-view

2.4.2.1

uncompetitive inhibition of alpha-D-ribose 1-phosphate

676239

1RFG, 3D-view

2.4.2.1

uncompetitive inhibition of alpha-D-ribose 1-phosphate

676239

3IEX, 3D-view

2.4.2.1

uncompetitive with alpha-D-1-ribose 1-phosphate as varied substrate

672404

1RFG, 3D-view

2.4.2.1

uncompetitive with alpha-D-1-ribose 1-phosphate as varied substrate

672404

3IEX, 3D-view

2.4.2.1

12 entries

2.4.2.16

1 mM, about 20% inhibition

639636

-

2.4.2.28

weak, competitive

637534

1JE1, 3D-view

2.4.2.28

weak, competitive

637534

1ODJ, 3D-view

2.4.2.28

2 entries

2.7.1.113

-

640553

-

2.7.1.20

0.1 mM, 10-90% inhibition

671917

-

2.7.1.20

no inhibition

641097

-

2.7.1.20

weak inhibition

641096

-

2.7.1.20

3 entries

2.7.1.67

1 mM, 50% inhibition

641791

-

2.7.1.73

inhibits phosphorylation of inosine

641923

6VWO, 3D-view

2.7.1.73

inhibits phosphorylation of inosine

641923

6VWP, 3D-view

2.7.6.1

20% inhibition at 1 mM

642717

-

2.7.6.1

no inhibition

642735

-

2.7.1.73

2 entries

2.7.6.1

2 entries

3.1.2.6

-

37432

-

3.1.3.2

-

701794

-

3.1.3.6

-

750491

-

3.1.5.B1

0.5 mM, 6% inhibition, substrate: dATP

768227

-

3.13.2.1

-

137127

-

3.2.2.1

competitive inhibitor of xanthosine hydrolysis

326370

-

3.2.2.14

addition of 1.4 mM, inhibition 44.6%

171773

-

3.2.2.8

-

137116

-

3.5.4.1

-

209484, 209492

-

3.5.4.3

at concentrations of 1 and 10 mM, guanosine shows weak inhibitory effect on both, guanine deaminase activity (1.8 and 12.5% inhibition) and dihydropterin deaminase activity (3.8 and 5.1% inhibition)

712380

-

3.5.4.4

-

209605, 209606

2QVN, 3D-view

3.5.4.5

-

209660

-

3.5.4.5

1.0 mM, 4% inhibition

209644

-

3.5.4.5

2 entries

4.4.1.5

-

37432

-

4.6.1.19

-

134494

-

6.3.4.2

-

674909, 727139

-

6.3.4.4

-

1539

-

6.3.5.2

0.5 mM, 50% inhibition

671905

-

3D Structure of Enzyme-Ligand-Complex (PDB) (38 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (38 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.12.98.2

6YK9, 3D-view

2.1.1.266

7P8Q, 3D-view

2.1.1.266

7P9I, 3D-view

2.1.1.266

7P8Q, 3D-view

2.1.1.266

7P9I, 3D-view

2.4.2.1

1RFG, 3D-view

2.4.2.1

3IEX, 3D-view

2.4.2.1

1RFG, 3D-view

2.4.2.1

3IEX, 3D-view

2.4.2.28

1JE1, 3D-view

2.4.2.28

1ODJ, 3D-view

2.4.2.28

1JE1, 3D-view

2.4.2.28

1ODJ, 3D-view

2.7.1.73

6VWO, 3D-view

2.7.1.73

6VWP, 3D-view

2.7.1.73

6VWO, 3D-view

2.7.1.73

6VWP, 3D-view

2.1.1.266

4 entries

2.4.2.1

4 entries

2.4.2.28

4 entries

2.7.1.73

4 entries

2.7.4.8

2AN9, 3D-view

2.7.7.50

4PZ6, 3D-view

2.7.7.7

1IH7, 3D-view

2.7.7.7

1WAF, 3D-view

2.7.7.7

3CFO, 3D-view

2.7.7.7

4I9L, 3D-view

2.7.7.7

1IH7, 3D-view

2.7.7.7

1WAF, 3D-view

2.7.7.7

3CFO, 3D-view

2.7.7.7

4I9L, 3D-view

2.7.7.7

8 entries

2.7.7.72

4X4N, 3D-view

3.2.1.17

6D9M, 3D-view

3.5.4.15

7DC9, 3D-view

3.5.4.15

7DQN, 3D-view

3.5.4.15

7DC9, 3D-view

3.5.4.15

7DQN, 3D-view

3.5.4.15

4 entries

3.5.4.4

2QVN, 3D-view

4.2.1.47

5VYR, 3D-view

4.2.1.47

5VYS, 3D-view

4.2.1.47

5VYR, 3D-view

4.2.1.47

5VYS, 3D-view

4.2.1.47

4 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (54 results)

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Show Turnover Number (54 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.2.1

0.25

-

mutant trimeric enzyme A196E/D238N, at pH 8.0 and 70°C

736075

2.4.2.1

0.26

-

wild type hexameric enzyme, at pH 8.0 and 70°C

736075

2.4.2.1

1

-

-

685103

2.4.2.1

1.1

-

-

672266

2.4.2.1

1.1

-

25°C, pH 7.4

672266

2.4.2.1

2

8

recombinant erythrocyte enzyme

673191

2.4.2.1

2.6

-

pH 7.4

674629, 705855

2.4.2.1

3.6

-

pH 7.4

674629

2.4.2.1

3.8

-

pH 7.4

705855

2.4.2.1

4

-

pH 7.0, 25°C

701915

2.4.2.1

7.8

-

pH 7.4, 25°C, wild-type heavy PNP

760069

2.4.2.1

8.3

-

pH 7.4, 25°C, mutant F159Y heavy PNP

760069

2.4.2.1

8.5

-

pH 7.4, 25°C, mutant F159Y light PNP

760069

2.4.2.1

8.7

-

pH 7.4, 25°C, wild-type light PNP

760069

2.4.2.1

10.4

-

recombinant mutant N256D, pH 7.0, 25°C

760019

2.4.2.1

12

-

pH 7.5

703607

2.4.2.1

13.4

-

native enzyme, at pH 7.4 and 25°C

737172

2.4.2.1

27

-

pH 7.4, 25°C

702230

2.4.2.1

28.05

-

80°C

673591

2.4.2.1

29.7

-

recombinant wild-type enzyme, pH 7.0, 25°C

760019

2.4.2.1

30

-

mutant L22E/H104R, pH 7.4, 25°C

702230

2.4.2.1

31

-

wild-tpe, pH 7.4, 25°C

702230

2.4.2.1

59

-

-

489678

2.4.2.1

60

-

mutant E201Q/N243D

704899

2.4.2.1

296

-

pH 7.0, 80°C

721355

2.4.2.1

876

-

pH 7.0, 90°C

726781

2.4.2.1

18400

-

pH 8.0, 50°C, recombinant enzyme

759810

2.4.2.28

7.31

-

-

637556

2.4.2.28

29.6

-

pH 7.4, 70°C

658681

2.4.2.1

27 entries

2.4.2.28

2 entries

2.7.1.20

0.5

-

51fold reduction

641115

2.7.1.B20

0.072

-

pH 8.0, 22°C

728780

3.2.2.1

0.0051

-

mutant C253A, ApH 7.5, 25°C

752135

3.2.2.1

0.011

-

mutant C42A, pH 7.5, 25°C

752135

3.2.2.1

0.143

-

wild-type, pH 7.5, 25°C

752135

3.2.2.1

0.84

-

-

654127

3.2.2.1

1.09

-

mutant enzyme C248P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

1.3

-

at pH 7.0 and 5°C

714225

3.2.2.1

1.4

-

mutant enzyme L250P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

1.7

-

mutant enzyme E249P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

1.9

-

pH 7.2, 35°C, His-tagged enzyme form

656488

3.2.2.1

2.3

-

wild type enzyme, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

2.3

-

wild-type, pH 7.0, 35°C

669883

3.2.2.1

2.5

-

mutant enzyme L251P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

2.7

-

mutant D40A, pH 7.0, 35°C

669883

3.2.2.1

3.9

-

mutant enzyme D253P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

4.1

-

mutant enzyme H247P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

9.8

-

mutant R252A, pH 7.0, 35°C

669883

3.2.2.1

13

-

mutant enzyme R252P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

29.1

-

at 80°C

695873

3.2.2.1

37.3

-

recombinant enzyme, pH 7.3, 37°C

731054

3.2.2.1

37.6

-

at pH 7.0 and 35°C

714225

3.2.2.1

20 entries

3.2.2.2

29.1

-

-

695873

3.2.2.8

0.0056

-

pH 7.0, 35°C, recombinant enzyme

664140

3.5.4.15

1.753

-

at pH 8.0 and 40°C

734892

K_M Value (100 results)

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Show KM Value (100 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.3.39

0.021

-

-

287628

2.4.2.1

0.0041

-

-

489693

2.4.2.1

0.0071

-

wild type hexameric enzyme, at pH 8.0 and 70°C

736075

2.4.2.1

0.0089

-

pH 7.4

705855

2.4.2.1

0.0094

-

pH 7.4

674629, 705855

2.4.2.1

0.01

-

-

489692

2.4.2.1

0.011

-

pH 7.0

489707

2.4.2.1

0.012

-

pH 7.0

489707

2.4.2.1

0.012

-

pH 7.0, 25°C

701915

2.4.2.1

0.012

-

recombinant erythrocyte enzyme

673191

2.4.2.1

0.014

-

pH 6.5

489707

2.4.2.1

0.0159

-

pH 6.5

489707

2.4.2.1

0.018

-

-

673191

2.4.2.1

0.0193

-

pH 7.0, 25°C

759175

2.4.2.1

0.02

-

-

489683

2.4.2.1

0.022

-

-

489670

2.4.2.1

0.029

-

-

489678, 489665

2.4.2.1

0.0341

-

pH 7.4, 25°C, wild-type light PNP

760069

2.4.2.1

0.035

-

-

489692

2.4.2.1

0.0399

-

pH 7.4, 25°C, wild-type heavy PNP

760069

2.4.2.1

0.042

-

wild-tpe, pH 7.4, 25°C

702230

2.4.2.1

0.0435

-

-

489682

2.4.2.1

0.0443

-

-

489658

2.4.2.1

0.046

-

pH 5.7

489707

2.4.2.1

0.047

-

-

489676

2.4.2.1

0.047

-

mutant L22E/H104R, pH 7.4, 25°C

702230

2.4.2.1

0.049

-

pH 7.4, 25°C

702230

2.4.2.1

0.05

-

-

489675

2.4.2.1

0.0542

-

pH 7.4, 25°C, mutant F159Y heavy PNP

760069

2.4.2.1

0.0564

-

pH 7.4, 25°C, mutant F159Y light PNP

760069

2.4.2.1

0.059

-

mutant E201Q/N243D

704899

2.4.2.1

0.06

-

-

489690, 672266

2.4.2.1

0.06

-

25°C, pH 7.4

672266

2.4.2.1

0.091

-

pH 5.7

489707

2.4.2.1

0.092

-

native enzyme, at pH 7.4 and 25°C

737172

2.4.2.1

0.11

-

-

489708, 489693

2.4.2.1

0.12

-

-

489679

2.4.2.1

0.122

-

80°C

673591

2.4.2.1

0.14

-

-

489667

2.4.2.1

0.155

-

pH 7.1, 25°C, wild-type enzyme

662643

2.4.2.1

0.187

-

-

685103

2.4.2.1

0.19

-

-

489703

2.4.2.1

0.206

-

pH 7.5

703607

2.4.2.1

0.216

-

-

489654

2.4.2.1

0.249

-

pH 7.1, 25°C, mutant enzyme Y191L

662643

2.4.2.1

0.34

-

-

489672

2.4.2.1

0.407

-

mutant trimeric enzyme A196E/D238N, at pH 8.0 and 70°C

736075

2.4.2.1

0.5

-

recombinant wild-type enzyme, pH 7.0, 25°C

760019

2.4.2.1

0.53

-

pH 7.0, 80°C

721355

2.4.2.1

0.69

-

pH 7.0, 90°C

726781

2.4.2.1

0.842

-

recombinant mutant N256D, pH 7.0, 25°C

760019

2.4.2.1

1.16

-

pH 8.0, 50°C, recombinant enzyme

759810

2.4.2.1

1.29

-

-

489698

2.4.2.1

1.85

-

at 40°C

489671

2.4.2.1

59.7

-

-

489699

2.4.2.15

0.056

-

at pH 7.5 and 30°C

766513

2.4.2.15

0.216

-

-

489774

2.4.2.28

0.1136

-

pH 7.4, 70°C

658681

2.4.2.28

0.916

-

-

637556

2.4.2.1

54 entries

2.4.2.15

2 entries

2.4.2.28

2 entries

2.7.1.20

2.24

-

pH 8.0, 37ºC

641115

2.7.1.73

0.0061

-

pH 7.2, 30°C

641925

2.7.1.73

0.014

-

-

641923

2.7.1.77

0.0064

-

pH 7.5, 37°C, reaction with 4-nitrophenyl phosphate

642003

2.7.1.77

2.13

-

pH 5.0, reaction with AMP

641994

2.7.1.B20

0.000208

-

pH 8.0, 22°C

728780

2.7.1.B20

0.062

-

pH 7.0, 70°C, cosubstrate: ATP

727430

2.7.1.B20

0.078

-

pH 7.0, 50°C, cosubstrate: ATP

727430

2.7.1.B20

0.46

-

pH 7.0, 37°C

697882

3.2.2.1

0.0018

-

mutant enzyme D253P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.0023

-

wild type enzyme, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.0023

-

wild-type, pH 7.0, 35°C

669883

3.2.2.1

0.003

-

mutant enzyme E249P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.00382

-

pH 7.2, 35°C, His-tagged enzyme form

656488

3.2.2.1

0.004

-

mutant enzyme C248P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.0045

-

at pH 7.0 and 35°C

714225

3.2.2.1

0.008

-

mutant enzyme H247P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.016

-

mutant enzyme L250P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.021

-

mutant enzyme L251P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.024

-

mutant enzyme R252P, in 50 mM potassium phosphate buffer, at 25°C and pH 7.0

698781

3.2.2.1

0.031

-

mutant R252A, pH 7.0, 35°C

669883

3.2.2.1

0.046

-

-

326380

3.2.2.1

0.054

-

mutant C42A, pH 7.5, 25°C

752135

3.2.2.1

0.0563

-

-

654255

3.2.2.1

0.066

-

mutant D40A, pH 7.0, 35°C

669883

3.2.2.1

0.068

-

wild-type, pH 7.5, 25°C

752135

3.2.2.1

0.075

-

recombinant enzyme, pH 7.3, 37°C

731054

3.2.2.1

0.16

-

at 80°C

695873

3.2.2.1

0.164

-

-

654127

3.2.2.1

0.3

-

mutant C253A, ApH 7.5, 25°C

752135

3.2.2.1

0.42

-

-

326379

3.2.2.1

7.5

-

-

326387

3.2.2.1

22.2

-

-

326392

3.2.2.2

0.0027

-

pH 4.8

683973

3.2.2.2

0.0085

-

-

137051

3.2.2.2

0.16

-

-

695873

3.2.2.8

0.363

-

pH 7.0, 35°C, recombinant enzyme

664140

3.2.2.8

0.6

-

-

137117

3.5.4.15

0.0098

-

-

209539

3.5.4.15

0.036

-

-

209536, 209537

3.5.4.15

0.264

-

at pH 8.0 and 40°C

734892

2.7.1.73

2 entries

2.7.1.77

2 entries

2.7.1.B20

4 entries

3.2.2.1

24 entries

3.2.2.2

3 entries

3.2.2.8

2 entries

3.5.4.15

3 entries

K_i Value (6 results)

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Show KI Value (6 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.2.1

0.01

-

inhibition of phosphorolysis of xanthosine

489707

2.4.2.1

0.01

-

with guanine as variable substrate and ribose 1-phosphate as fixed substrate

489658

2.4.2.1

0.0313

-

with guanine as variable substrate and 0.4 mM ribose 1-phosphate

489682

2.4.2.1

0.8

-

25°C, pH 7.0, about, with alpha-D-ribose 1-phosphate as varied substrate

672404

2.4.2.1

0.8

-

versus alpha-D-ribose 1-phosphate

676239

2.4.2.1

5 entries

3.1.3.6

0.03229

-

at pH 7.4 and 25°C

750491

IC₅₀ Value (12 results)

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Show IC50 Value (12 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

6.3.4.2

0.22

-

5.44 mM NH3, IC50 for inhibition of NH3-dependent CTP formation

674909

6.3.4.2

0.26

-

1.36 mM NH3, IC50 for inhibition of NH3-dependent CTP formation

674909

6.3.4.2

0.26

-

2.72 mM NH3, IC50 for inhibition of NH3-dependent CTP formation

674909

6.3.4.2

0.29

-

8.16 mM NH3, IC50 for inhibition of NH3-dependent CTP formation

674909

6.3.4.2

0.29

-

IC50 for inhibition of NH3-dependent CTP formation

674909

6.3.4.2

0.3

-

0.30 mM Gln, IC50 for inhibition of Gln-dependent CTP formation

674909

6.3.4.2

0.32

-

10 mM Gln, IC50 for inhibition of Gln-dependent CTP formation

674909

6.3.4.2

0.32

-

2.5 mM Gln, IC50 for inhibition of Gln-dependent CTP formation

674909

6.3.4.2

0.32

-

IC50 for inhibition of Gln-dependent CTP formation

674909

6.3.4.2

0.35

-

0.75 mM Gln, IC50 for inhibition of Gln-dependent CTP formation

674909

6.3.4.2

0.38

-

in HEPES buffer (70 mM, pH 7.3), at 37°C

727139

6.3.4.2

11 entries

6.3.5.2

0.5

-

37°C, pH 8.5

671905

References & Links

Literature References (292)

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Show Reference (292 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1539

7213642

Purification and properties of adenylosuccinate synthetase from Yoshida sarcoma ascites tumor cells

1980

Matsuda, Y.; Shimura, K.; Shiraki, H.; Nakagawa, H.

Biochim. Biophys. Acta

616

340-350

37432

7417280

Inhibitors of glyoxalase enzymes

1980

Oray, B.; Norton, S.J.

Biochem. Biophys. Res. Commun.

95

624-629

95021

-

Manganese-dependent production, and properties, of 5'-nucleotidase by alkalophilic Bacillus No. A-59

1989

Ikura, Y.; Horikoshi, K.

Agric. Biol. Chem.

53

645-649

95025

2848805

High Km soluble 5'-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP

1988

Spychala, J.; Madrid-Marina, V.; Fox, I.H.

J. Biol. Chem.

263

18759-18765

95026

2831062

Purification of bovine liver cytosolic 5'-nucleotidase. Kinetic and structural studies as compared to the membrane isoenzyme

1988

Zekri, M.; Harb, J.; Bernard, S.; Meflah, K.

Eur. J. Biochem.

172

93-99

95027

2835422

Properties of the membrane-bound 5'-nucleotidase and utilization of extracellular ATP in Vibrio parahaemolyticus

1987

Sakai, Y.; Toda, K.; Mitani, Y.; Tsuda, M.; Shinoda, S.; Tsuchiya, T.

J. Gen. Microbiol.

133

2751-2757

95028

2822031

Purification, characterization and cellular localization of 5'-nucleotidase from Torpedo electric organ

1987

Grondal, E.J.M.; Zimmermann, H.

Biochem. J.

245

805-810

95031

-

Properties of 5'-nucleotidase from nodules of pigeonpea (Cajanus cajan)

1986

Singh, A.; Singh, R.

Phytochemistry

25

2267-2270

95032

3028048

Properties of cytosol 5-nucleotidase and its role in purine nucleotide metabolism

1986

Tsushima, K.

Adv. Enzyme Regul.

25

181-200

95033

-

Purification and properties of 5'-nucleotidase from cod muscle

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