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Ligand 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 9 H2 4 O4
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
YUHVBHDSVLKFNI-MHVYXZCWSA-N
3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione
Show all BRENDA pathways known for 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FADH2 + O2 = 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FAD + H2O
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Substrate in Enzyme-catalyzed Reactions (1 result)
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3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
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Product in Enzyme-catalyzed Reactions (2 results)
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3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FADH2 + O2 = 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FAD + H2O
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3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FMN + H2O
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Enzyme Kinetic Parameters
References & Links Literature References (4)
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Nonheme iron dioxygenase
1974
Nozaki, M.
Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York
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135-165
3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase from Nocardia restrictus. I. Isolation of the enzyme and study of its physical and chemical properties
1970
Tai, H.H.; Sih, C.J.
J. Biol. Chem.
245
5062-5071
Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms
1966
Gibson, D.T.; Wang, K.C.; Sih, C.J.; Whitlock, H.
J. Biol. Chem.
241
551-559
The genes encoding the hydroxylase of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione in steroid degradation in Comamonas testosteroni TA441
2004
Horinouchi, M.; Hayashi, T.; Kudo, T.
J. Steroid Biochem. Mol. Biol.
92
143-154
Links to other databases for 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione