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Ligand N1-methyl-GTP

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.50

N1-methyl-GTP + pp(5')RNA = N1-methyl-G(5')ppp(5')RNA + diphosphate

739485

-

5.6.2.6

N1-methyl-GTP + H2O = N1-methyl-GDP + phosphate

713144

-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.50

-

739485

-

5.6.2.6

-

713144

-

Enzyme Kinetic Parameters

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.6.2.6

2.6

-

pH 7.5, 37°C, wild-type enzyme, inhibition of the ATPase reaction

713144

IC₅₀ Value (2 results)

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Show IC50 Value (2 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.7.7.50

0.08

-

IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C

739485

5.6.2.6

3.5

-

pH 7.5, 37°C, wild-type enzyme, inhibition of the ATPase reaction

713144

References & Links

Literature References (2)

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Show Reference (2 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

713144

20421212

Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase

2010

Despins, S.; Issur, M.; Bougie, I.; Bisaillon, M.

Nucleic Acids Res.

38

5493-5506

739485

24086504

Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism

2013

Issur, M.; Bougie, I.; Despins, S.; Bisaillon, M.

PLoS ONE

8

e75310

Links to other databases for N1-methyl-GTP

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Show Links (1 entry)