Ligand p-chloromercuriphenylsulfonic acid

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Basic Ligand Information

Molecular Structure
Picture of p-chloromercuriphenylsulfonic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6ClHgO3S
p-chloromercuriphenylsulfonic acid
XXEBDPRHFAWOND-UHFFFAOYSA-M
Synonyms:
4-chlormercuriphenylsulfonic acid, 4-chloro-mercuriphenylsulfonic acid, 4-chloromercuribenzene sufonic acid, 4-chloromercuribenzenesulfonate, 4-chloromercuribenzene sulfonate, 4-chloromercuribenzenesulfonic acid, 4-Chloromercuriphenylsulfonate, 4-Chloromercuriphenyl sulfonate, 4-chloromercuriphenylsulfonic acid, 4-chloromercuriphenyl sulfonic acid, chloromercuribenzene-p-sulfonic acid, chloromercuribenzene 4-sulfonate, chloromercuriphenylsulfonate, p-(chloromercuri)-benzenesulfonic acid, p-(chloromercuri)benzene sulfonate, p-chlormercuriphenylsulfonic acid, p-chloromercuri-benzene sulfonate, p-chloromercuribenzene-sulfonic acid, p-chloromercuribenzene-sulphonic acid, p-chloromercuribenzene sulfonate, p-chloromercuribenzenesulfonate, p-chloromercuribenzenesulfonic acid, p-chloromercuribenzene sulfonic acid, p-chloromercuribenzenesulphonic acid, p-chloromercuric benzene sulfonate, p-chloromercuriphenyl-sulfonic acid, p-chloromercuriphenyl sulfonate, p-chloromercuriphenylsulfonate, p-chloromercuriphenylsulfonic-acid, p-chloromercuriphenyl sulfonic acid, p-chloromercuriphenylsulphonate, p-chloromercuriphenyl sulphonic acid, p-Chloromercurisulfonic acid, p-chloromercuryphenylsulfonate, p-chloromercuryphenylsulfonic acid, p-Chlororomercuriphenyl sulfonate, p-Choromercuribenzenesulfonate, p-Choromercuriphenylsulfonate, para-chloromercuribenzenesulfonate, pchloromercuriphenylsulfonate, pchloromercuriphenylsulfonic acid, PCMBS

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin
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Inhibitor in Enzyme-catalyzed Reactions (245 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
46% inhibition at 0.1 mM
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inhibits both activities of the enzyme
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95% inhibition at 0.1 mM
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0.001 mM, complete inhibition
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100% inhibition at 0.05 mM, recombinant enzyme 1 and 2
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1 mM; 87% inhibition
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inactivates enzyme completely at 0.1 mM
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1 mM, 35% inhibition
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80% inhibition at 0.1 mM
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98% inhibition at 0.001 mM
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8 mol per mol enzyme, complete inhibition
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40% inhibition at 20 mM
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more than 50% loss in activity in 60 min at 0.05 mM
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inactivetes, can be reversed by addition of cysteine
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0.1 mM, complete inhibition of enzyme from cultured aortic smooth muscle cells
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0.1 mM, complete inhibition
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60% inhibition at 0.025 mM, inhibition can be reversed by an excess of thiol compounds
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62% inhibition at 1 mM
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strong
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0.02 mM
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potent inhibition
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complete inhibition at 1 mM
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0.16 mM, 97% inhibition
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complete inhibition, DTT protects
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50% inhibition of ACAT1 at 0.01 mM, Cys467 is one of the major targets for inhibition
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activity abolished at 6 mM
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UGT71F1, 0.01mM, 22% inhibition; UGT73A4 activity is completely inhibited at 0.01mM
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irreversible
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46% inhibition at 1 mM
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inhibition of gamma-elimination
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reversible by cysteine or 2-mercaptoethanol
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0.1 mM, completely inhibits 4HB geranyltransferase activity
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0.02 mM, 92% inhibition, addition of 1 mM glutathione protects to 100%
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0.025 mM, 80% inhibition of PFK III, reversed by 2-mercaptoethanol, dithiothreitol or reduced glutathione
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strong inhibition at 0.1 mM
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50% inhibition at 0.0000038 mM
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2-mercaptoethanol protects
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0.2 mM strongly inhibitory
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20-25% inhibition in presence of 0.0001 M
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100% inhibition at 1 mM
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0.1 mM, 98% inhibition
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41% inhibition at 1 mM
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weak inhibition
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strong, with p-nitrophenyl-beta-D-glucopyranoside as substrate
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potent inhibitor
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strong inhibition at 1 mM
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1 mM, 12% inhibition
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1 mM, 60% inhibition
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strong inhibition
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0.1 mM, relative activity: 0%
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IC50: 0.27 mM
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1 mM, 15% inhibition
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0.1 mM and 1 mM, complete inhibition
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10 mM, 13% inhibition
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1 mM, 96% inhibition
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strong inhibition at 0.05 mM
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27% inhibited by 0.01 mM
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1 mM, 39% inhibition, addition of 10 mM dithiothreitol restores activity to 100%
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0.1 mM, complete inhibition
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complete inhibition
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strong
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1 mM, 56% of inhibition
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10 mM, 50% inhibition
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86% inhibition at 5 mM
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complete inhibition at 0.1 mM
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2 mM, complete inhibition
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strong inhibition
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inhibition is reversed by Cys
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96% inhibition at 1 mM
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activity is not restored by treatment with 2-mercaptoethanol
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0.1 mM, 50% inhibition
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FGK2 complex
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Enzyme Kinetic Parameters

Ki Value (3 results)

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EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
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pH 7.2, 25°C
0.025
-
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0.0025
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IC50 Value (2 results)

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EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.04
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IC50: 0.04 mM
0.27
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IC50: 0.27 mM

References & Links

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Links to other databases for p-chloromercuriphenylsulfonic acid

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ChEBI
PubChem
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PubChem