Ligand N8-Acetylspermidine

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Basic Ligand Information

Molecular Structure
Picture of N8-Acetylspermidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H21N3O
N8-Acetylspermidine
FONIWJIDLJEJTL-UHFFFAOYSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N8-acetylspermidine + O2 + H2O = 1,3-diaminopropanal + H2O2 + ?
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N8-acetylspermidine + H2O = acetate + spermidine
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N8-acetylspermidine + H2O = acetate + spermidine
show the reaction diagram

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N8-acetylspermidine + O2 + H2O = ?
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N8-acetylspermidine + H2O + O2 = ?
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N8-acetylspermidine + O2 + H2O = 1,3-diaminopropane + ?
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N8-acetylspermidine + electron acceptor = ? + reduced electron acceptor
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acetyl-CoA + N8-acetylspermidine = CoA + N1,N8-diacetylspermidine
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N8-acetylspermidine + H2O = acetate + spermidine
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N8-acetylspermidine + H2O = acetate + spermidine
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glutathione + N8-acetylspermidine + ATP = N1-glutathionyl-N8-acetylspermidine + ADP + phosphate
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulation of cell growth due to inhibition of N8-acetylspremidine deacetylase, maximum cell growth stimulation above 1 mM

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.6
-
pH 7.2, 37C
22.4
-
pH 9.0, 20C

KM Value (14 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.64
-
pH 7.2, 37C
0.105
-
37C, pH 8
0.027
-
pH 9.0, 20C
1.4
-
-
0.377
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for N8-Acetylspermidine

ChEBI
PubChem
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PubChem