Ligand N2-Acetyl-L-ornithine

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Basic Ligand Information

Molecular Structure
Picture of N2-Acetyl-L-ornithine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H14N2O3
N2-Acetyl-L-ornithine
JRLGPAXAGHMNOL-LURJTMIESA-N
Synonyms:
2-N-acetyl-L-ornithine, acetylornithine, alpha-N-acetyl-L-ornithine, alpha-N-acetylornithine, N-acetyl-L-ornithine, N-acetylornithine, N-alpha-acetyl-L-ornithine, N2-acety-L-ornithine, N2-acetylornithine, N2-alpha-acetyl-L-ornithine, N2-L-acetyl ornithine, Nalpha-acety-L-ornithine, Nalpha-Acetyl-L-ornithine


Show all pahtways known for Show all BRENDA pathways known for N2-Acetyl-L-ornithine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline
show the reaction diagram
N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate
show the reaction diagram
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N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate = N2-acetyl-L-ornithine + 2-oxoglutarate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-N-acetylornithine + pyruvate + NADPH + H+ = ? + NADP+ + H2O
show the reaction diagram
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N-acetyl-L-ornithine + carbamoyl phosphate = N-acetyl-L-citrulline + phosphate
show the reaction diagram
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carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline
show the reaction diagram
N2-acetyl-L-ornithine + 2-oxoglutarate = (2R)-2-acetamido-5-oxopentanoic acid + L-glutamate
show the reaction diagram
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N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
show the reaction diagram
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N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
show the reaction diagram
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N-acetyl-L-ornithine + H2O = acetate + L-ornithine
show the reaction diagram
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N2-acetyl-L-ornithine + H2O = L-ornithine + acetate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-ornithine + N-acetyl-L-glutamate = N2-acetyl-L-ornithine + L-glutamate
show the reaction diagram
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N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate = N2-acetyl-L-ornithine + 2-oxoglutarate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive with L-ornithine
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.55
-
25°C, pH 9.5
1
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pH 8.9, 45°C
4.7
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pH 8.0, temperature not specified in the publication
0.00049
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pH 7.0, 37°C

KM Value (41 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0119
-
mutant P90E/T242L, pH 8.3, 25°C
0.8
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pH 8.9, 45°C
0.338
-
pH 8.0, temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0088
-
pH 8, 37°C

References & Links

Links to other databases for N2-Acetyl-L-ornithine

ChEBI
PubChem
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PubChem