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Ligand tolfenamic acid Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 4 H1 2 ClNO2
tolfenamic acid
YEZNLOUZAIOMLT-UHFFFAOYSA-N
2-(3-chloro-2-methylanilino)benzoic acid
Roles as Enzyme Ligand
Inhibitor in Enzyme-catalyzed Reactions (4 results)
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0.04 mM, 44% inhibition, MIC for growth of Brucella melitensis 0.025 mM
-
3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)
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Enzyme Kinetic Parameters
Ki Value (1 result)
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IC50 Value (4 results)
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0.032
-
at 0.025 mM ATP, pH 7.4, 22°C, recombinant enzyme
0.07
-
at 0.1 mM ATP, pH 7.4, 22°C, recombinant enzyme
0.0092
-
isoform PanK3, at pH 7.5 and 37°C
References & Links Literature References (4)
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Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions
2007
Oselin, K.; Anier, K.
Drug Metab. Dispos.
35
1452-1454
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain
2010
Leonardi, R.; Zhang, Y.M.; Yun, M.K.; Zhou, R.; Zeng, F.Y.; Lin, W.; Cui, J.; Chen, T.; Rock, C.O.; White, S.W.; Jackowski, S.
Chem. Biol.
17
892-902
Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing
2018
Medarametla, P.; Gatta, V.; Kajander, T.; Laitinen, T.; Tammela, P.; Poso, A.
ChemMedChem
13
2400-2407
Identification of small-molecule inhibitors of Brucella diaminopimelate decarboxylase by using a high-throughput screening assay
2020
Bie, P.; Yang, X.; Zhang, C.; Wu, Q.
Front. Microbiol.
10
2936
Links to other databases for tolfenamic acid
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