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Ligand [histone H3]-L-lysine9

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

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Show Natural Substrate (8 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.355

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9

753905, 754387, 754819, 754853, 755057, 755156, 755134, 752498, 754061, 752821, 753181, 753202, 753293, 753592, 753662, 753676, 753746, 776959, 777391, 776699

-

2.1.1.355

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9

754930

-

2.1.1.355

S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9

753905, 754387, 754819, 755156, 752498, 754061, 753181, 753202, 753293, 753662, 753676, 753746

-

2.1.1.355

S-adenosyl-L-methionine + [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine9

754930

-

2.1.1.355

4 entries

2.1.1.367

S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9

756364

-

2.1.1.368

2 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9

778582, 777955

-

2.1.1.368

S-adenosyl-L-methionine + [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine9

758007

-

2.1.1.368

2 entries

2.3.1.48

acetyl-CoA + [histone H3]-L-lysine9 = CoA + [histone H3]-N6-acetyl-L-lysine9

756646, 755950, 756850, 757517

-

In Vivo Product in Enzyme-catalyzed Reactions (13 results)

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Show Natural Product (13 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.27

[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.65

a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.65

a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

[histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.65

[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.66

histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.66

[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.66

[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 3 2-oxoglutarate + 3 O2 = [histone H3]-L-lysine9 + 3 succinate + 3 formaldehyde + 3 CO2

-

-

1.14.11.66

[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.66

[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

6 entries

1.14.11.66

5 entries

1.14.99.66

[histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2

-

-

Substrate in Enzyme-catalyzed Reactions (9 results)

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Show Substrate (9 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.355

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9

753905, 754387, 754819, 754853, 755057, 755156, 755134, 752498, 754061, 752821, 753181, 753202, 753293, 753592, 753662, 753676, 753746, 776959, 777391, 776699

-

2.1.1.355

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9

754930

-

2.1.1.355

S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9

753905, 754387, 754819, 755156, 752498, 754061, 753181, 753202, 753293, 753662, 753676, 753746

-

2.1.1.355

S-adenosyl-L-methionine + [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine9

754930

-

2.1.1.355

4 entries

2.1.1.367

S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9

756364, 777552

-

2.1.1.368

2 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9

778582, 777955, 777552

-

2.1.1.368

S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9

758007, 777552

-

2.1.1.368

S-adenosyl-L-methionine + [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine9

758007

-

2.1.1.368

3 entries

2.3.1.48

acetyl-CoA + [histone H3]-L-lysine9 = CoA + [histone H3]-N6-acetyl-L-lysine9

756646, 755950, 756850, 757517, 756657, 778575

-

Product in Enzyme-catalyzed Reactions (22 results)

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Show Product (22 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.27

[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.65

a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.65

a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

[histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.65

[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.66

histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.66

[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.66

[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 3 2-oxoglutarate + 3 O2 = [histone H3]-L-lysine9 + 3 succinate + 3 formaldehyde + 3 CO2

-

-

1.14.11.66

[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

-

-

1.14.11.66

[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine9 + succinate + formaldehyde + CO2

-

-

1.14.11.65

6 entries

1.14.11.66

5 entries

1.14.99.66

[histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 = [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2

-

-

2.3.1.286

NAD+ + [histone H3]-N6-acetyl-L-lysine9 = nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose

-

-

2.3.1.286

[histone H3]-N6-acetyl-L-lysine9 + NAD+ + H2O = [histone H3]-L-lysine9 + 2''-O-acetyl-ADP-D-ribose + nicotinamide

-

-

2.3.1.286

[histone H3]-N6-butyryl-L-lysine9 + NAD+ + H2O = [histone H3]-L-lysine9 + 2''-O-butyryl-ADP-D-ribose + nicotinamide

-

-

2.3.1.286

[histone H3]-N6-myristoyl-L-lysine9 + NAD+ + H2O = [histone H3]-L-lysine9 + 2''-O-myristoyl-ADP-D-ribose + nicotinamide

-

-

2.3.1.286

[histone H3]-N6-octanoyl-L-lysine9 + NAD+ + H2O = [histone H3]-L-lysine9 + 2''-O-octanoyl-ADP-D-ribose + nicotinamide

-

-

2.3.1.286

5 entries

2.3.1.B43

NAD+ + [histone H3]-N6-succinyl-L-lysine9 + H2O = nicotinamide + [histone H3]-L-lysine9 + 2'-O-succinyl-ADP-ribose

-

-

3.5.1.138

[histone H3]-N6-[(R)-acetyl]-L-lysine9 + H2O = [histone H3]-L-lysine9 + acetate

-

-

3.5.1.138

[histone H3]-N6-[(R)-biotinyl]-L-lysine9 + H2O = [histone H3]-L-lysine9 + biotin

-

-

3.5.1.138

[histone H3]-N6-[(R)-lipoyl]-L-lysine9 + H2O = [histone H3]-L-lysine9 + (R)-lipoate

-

-

3.5.1.138

3 entries

Enzyme Kinetic Parameters

References & Links

Literature References (50)

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Show Reference (50 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

752498

25613390

The H3K9 methyltransferase G9a represses E-cadherin and is associated with myometrial invasion in endometrial cancer

2015

Hsiao, S.M.; Chen, M.W.; Chen, C.A.; Chien, M.H.; Hua, K.T.; Hsiao, M.; Kuo, M.L.; Wei, L.H.

Ann. Surg. Oncol.

22

S1556-S1565

752821

29101051

Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1

2018

Xue, W.; Huang, J.; Chen, H.; Zhang, Y.; Zhu, X.; Li, J.; Zhang, W.; Yuan, Y.; Wang, Y.; Zheng, L.; Huang, K.

Biochim. Biophys. Acta

1864

338-346

752821

29101051

Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1

2018

Xue, W.; Huang, J.; Chen, H.; Zhang, Y.; Zhu, X.; Li, J.; Zhang, W.; Yuan, Y.; Wang, Y.; Zheng, L.; Huang, K.

Biochim. Biophys. Acta

1864

338-346

753181

31515511

Histone methyltransferase G9a protects against acute liver injury through GSTP1

2019

Zhang, Y.; Xue, W.; Zhang, W.; Yuan, Y.; Zhu, X.; Wang, Q.; Wei, Y.; Yang, D.; Yang, C.; Chen, Y.; Sun, Y.; Wang, S.; Huang, K.; Zheng, L.

Cell Death Differ.

27

1243-1258

753181

31515511

Histone methyltransferase G9a protects against acute liver injury through GSTP1

2019

Zhang, Y.; Xue, W.; Zhang, W.; Yuan, Y.; Zhu, X.; Wang, Q.; Wei, Y.; Yang, D.; Yang, C.; Chen, Y.; Sun, Y.; Wang, S.; Huang, K.; Zheng, L.

Cell Death Differ.

27

1243-1258

753202

30943408

Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection

2019

Au Yeung, W.K.; BrindAmour, J.; Hatano, Y.; Yamagata, K.; Feil, R.; Lorincz, M.C.; Tachibana, M.; Shinkai, Y.; Sasaki, H.

Cell Rep.

27

282-293.e4

753202

30943408

Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection

2019

Au Yeung, W.K.; BrindAmour, J.; Hatano, Y.; Yamagata, K.; Feil, R.; Lorincz, M.C.; Tachibana, M.; Shinkai, Y.; Sasaki, H.

Cell Rep.

27

282-293.e4

753293

28778944

Histone methyltransferase G9a is required for cardiomyocyte homeostasis and hypertrophy

2017

Papait, R.; Serio, S.; Pagiatakis, C.; Rusconi, F.; Carullo, P.; Mazzola, M.; Salvarani, N.; Miragoli, M.; Condorelli, G.

Circulation

136

1233-1246

753293

28778944

Histone methyltransferase G9a is required for cardiomyocyte homeostasis and hypertrophy

2017

Papait, R.; Serio, S.; Pagiatakis, C.; Rusconi, F.; Carullo, P.; Mazzola, M.; Salvarani, N.; Miragoli, M.; Condorelli, G.

Circulation

136

1233-1246

753592

28957455

Histone H3 lysine 9 methyltransferase FvDim5 regulates fungal development, pathogenicity and osmotic stress responses in Fusarium verticillioides

2017

Gu, Q.; Ji, T.; Sun, X.; Huang, H.; Zhang, H.; Lu, X.; Wu, L.; Huo, R.; Wu, H.; Gao, X.

FEMS Microbiol. Lett.

364

fnx184

753592

28957455

Histone H3 lysine 9 methyltransferase FvDim5 regulates fungal development, pathogenicity and osmotic stress responses in Fusarium verticillioides

2017

Gu, Q.; Ji, T.; Sun, X.; Huang, H.; Zhang, H.; Lu, X.; Wu, L.; Huo, R.; Wu, H.; Gao, X.

FEMS Microbiol. Lett.

364

fnx184

753662

26441991

Functional role of G9a histone methyltransferase in cancer

2015

Casciello, F.; Windloch, K.; Gannon, F.; Lee, J.S.

Front. Immunol.

6

487

753662

26441991

Functional role of G9a histone methyltransferase in cancer

2015

Casciello, F.; Windloch, K.; Gannon, F.; Lee, J.S.

Front. Immunol.

6

487

753676

27597848

Histone H3 lysine 9 methyltransferase DIM5 is required for the development and virulence of Botrytis cinerea

2016

Zhang, X.; Liu, X.; Zhao, Y.; Cheng, J.; Xie, J.; Fu, Y.; Jiang, D.; Chen, T.

Front. Microbiol.

7

1289

753676

27597848

Histone H3 lysine 9 methyltransferase DIM5 is required for the development and virulence of Botrytis cinerea

2016

Zhang, X.; Liu, X.; Zhao, Y.; Cheng, J.; Xie, J.; Fu, Y.; Jiang, D.; Chen, T.

Front. Microbiol.

7

1289

752821

2 entries

753181

2 entries

753202

2 entries

753293

2 entries

753592

2 entries

753662

2 entries

753676

2 entries

753746

30923167

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase

2019

Jang, S.; Kang, C.; Yang, H.S.; Jung, T.; Hebert, H.; Chung, K.Y.; Kim, S.J.; Hohng, S.; Song, J.J.

Genes Dev.

33

620-625

753905

27916793

Histone H3 methyltransferase Suv39h1 prevents myogenic terminal differentiation by repressing MEF2 activity in muscle cells

2016

Jin, W.; Shang, Y.; Peng, J.; Jiang, S.

Int. J. Mol. Sci.

17

1908

754061

11316813

Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3

2001

Tachibana, M.; Sugimoto, K.; Fukushima, T.; Shinkai, Y.

J. Biol. Chem.

276

25309-25317

754387

28135087

Discovery of potent and selective inhibitors for G9a-like protein (GLP) lysine methyltransferase

2017

Xiong, Y.; Li, F.; Babault, N.; Dong, A.; Zeng, H.; Wu, H.; Chen, X.; Arrowsmith, C.H.; Brown, P.J.; Liu, J.; Vedadi, M.; Jin, J.

J. Med. Chem.

60

1876-1891

754819

26807716

A two-state activation mechanism controls the histone methyltransferase Suv39h1

2016

Mueller, M.M.; Fierz, B.; Bittova, L.; Liszczak, G.; Muir, T.W.

Nat. Chem. Biol.

12

188-193

754819

26807716

A two-state activation mechanism controls the histone methyltransferase Suv39h1

2016

Mueller, M.M.; Fierz, B.; Bittova, L.; Liszczak, G.; Muir, T.W.

Nat. Chem. Biol.

12

188-193

754853

30297796

The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells

2018

Smolko, A.E.; Shapiro-Kulnane, L.; Salz, H.K.

Nat. Commun.

9

4155

754853

30297796

The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells

2018

Smolko, A.E.; Shapiro-Kulnane, L.; Salz, H.K.

Nat. Commun.

9

4155

754930

31165882

Disordered region of H3K9 methyltransferase Clr4 binds the nucleosome and contributes to its activity

2019

Akoury, E.; Ma, G.; Demolin, S.; Broenner, C.; Zocco, M.; Cirilo, A.; Ivic, N.; Halic, M.

Nucleic Acids Res.

47

6726-6736

754930

31165882

Disordered region of H3K9 methyltransferase Clr4 binds the nucleosome and contributes to its activity

2019

Akoury, E.; Ma, G.; Demolin, S.; Broenner, C.; Zocco, M.; Cirilo, A.; Ivic, N.; Halic, M.

Nucleic Acids Res.

47

6726-6736

755057

30860988

The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption

2019

Riahi, H.; Brekelmans, C.; Foriel, S.; Merkling, S.H.; Lyons, T.A.; Itskov, P.M.; Kleefstra, T.; Ribeiro, C.; van Rij, R.P.; Kramer, J.M.; Schenck, A.

PLoS Biol.

17

e2006146

755057

30860988

The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption

2019

Riahi, H.; Brekelmans, C.; Foriel, S.; Merkling, S.H.; Lyons, T.A.; Itskov, P.M.; Kleefstra, T.; Ribeiro, C.; van Rij, R.P.; Kramer, J.M.; Schenck, A.

PLoS Biol.

17

e2006146

755134

27798683

Ubiquitination of lysine 867 of the human SETDB1 protein upregulates its histone H3 lysine 9 (H3K9) methyltransferase activity

2016

Ishimoto, K.; Kawamata, N.; Uchihara, Y.; Okubo, M.; Fujimoto, R.; Gotoh, E.; Kakinouchi, K.; Mizohata, E.; Hino, N.; Okada, Y.; Mochizuki, Y.; Tanaka, T.; Hamakubo, T.; Sakai, J.; Kodama, T.; Inoue, T.; Tachibana, K.; Doi, T.

PLoS ONE

11

e0165766

755134

27798683

Ubiquitination of lysine 867 of the human SETDB1 protein upregulates its histone H3 lysine 9 (H3K9) methyltransferase activity

2016

Ishimoto, K.; Kawamata, N.; Uchihara, Y.; Okubo, M.; Fujimoto, R.; Gotoh, E.; Kakinouchi, K.; Mizohata, E.; Hino, N.; Okada, Y.; Mochizuki, Y.; Tanaka, T.; Hamakubo, T.; Sakai, J.; Kodama, T.; Inoue, T.; Tachibana, K.; Doi, T.

PLoS ONE

11

e0165766

754819

2 entries

754853

2 entries

754930

2 entries

755057

2 entries

755134

2 entries

755156

29145444

Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway

2017

Ho, J.C.; Abdullah, L.N.; Pang, Q.Y.; Jha, S.; Chow, E.K.; Yang, H.; Kato, H.; Poellinger, L.; Ueda, J.; Lee, K.L.

PLoS ONE

12

e0188051

755950

27993678

Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana

2017

Aquea, F.; Timmermann, T.; Herrera-Vasquez, A.

Biochem. Biophys. Res. Commun.

483

664-668

755950

27993678

Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana

2017

Aquea, F.; Timmermann, T.; Herrera-Vasquez, A.

Biochem. Biophys. Res. Commun.

483

664-668

756364

22939622

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity

2012

Pinheiro, I.; Margueron, R.; Shukeir, N.; Eisold, M.; Fritzsch, C.; Richter, F.M.; Mittler, G.; Genoud, C.; Goyama, S.; Kurokawa, M.; Son, J.; Reinberg, D.; Lachner, M.; Jenuwein, T.

Cell

150

948-960

756364

22939622

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity

2012

Pinheiro, I.; Margueron, R.; Shukeir, N.; Eisold, M.; Fritzsch, C.; Richter, F.M.; Mittler, G.; Genoud, C.; Goyama, S.; Kurokawa, M.; Son, J.; Reinberg, D.; Lachner, M.; Jenuwein, T.

Cell

150

948-960

756646

28644986

Designing novel inhibitors against histone acetyltransferase (HAT xa0GCN5) of Plasmodium falciparum

2017

Kumar, A.; Bhowmick, K.; Vikramdeo, K.; Mondal, N.; Subbarao, N.; Dhar, S.

Eur. J. Med. Chem.

138

26-37

756646

28644986

Designing novel inhibitors against histone acetyltransferase (HAT xa0GCN5) of Plasmodium falciparum

2017

Kumar, A.; Bhowmick, K.; Vikramdeo, K.; Mondal, N.; Subbarao, N.; Dhar, S.

Eur. J. Med. Chem.

138

26-37

755950

2 entries

756364

2 entries

756646

2 entries

756657

31195169

Histone acetyltransferase inhibitors An overview in synthesis, structure-activity relationship and molecular mechanism

2019

Huang, M.; Huang, J.; Zheng, Y.; Sun, Q.

Eur. J. Med. Chem.

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259-286

756850

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Lysine acetyltransferase inhibitors structure-activity relationships and potential therapeutic implications

2018

Fiorentino, F.; Mai, A.; Rotili, D.

Future Med. Chem.

10

1067-1091

756850

29676588

Lysine acetyltransferase inhibitors structure-activity relationships and potential therapeutic implications

2018

Fiorentino, F.; Mai, A.; Rotili, D.

Future Med. Chem.

10

1067-1091

757517

29801653

Roles for lysine acetyltransferases during mammalian hibernation

2018

Rouble, A.N.; Hawkins, L.J.; Storey, K.B.

J. Therm. Biol.

74

71-76

757517

29801653

Roles for lysine acetyltransferases during mammalian hibernation

2018

Rouble, A.N.; Hawkins, L.J.; Storey, K.B.

J. Therm. Biol.

74

71-76

758007

15546353

Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation

2004

Yu, Y.; Dong, A.; Shen, W.H

Plant J.

40

699-711

758007

15546353

Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation

2004

Yu, Y.; Dong, A.; Shen, W.H

Plant J.

40

699-711

756850

2 entries

757517

2 entries

758007

2 entries

776699

38058121

Diversity and functional specialization of H3K9-specific histone methyltransferases

2024

Koryakov, D.E.

Bioessays

46

e2300163

776959

34010645

The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin

2021

Shan, C.M.; Kim, J.K.; Wang, J.; Bao, K.; Sun, Y.; Chen, H.; Yue, J.X.; Stirpe, A.; Zhang, Z.; Lu, C.; Schalch, T.; Liti, G.; Nagy, P.L.; Tong, L.; Qiao, F.; Jia, S.

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777391

35096813

H3K9 Methyltransferases Suv39h1 and Suv39h2 control the differentiation of neural progenitor cells in the adult hippocampus

2021

Guerra, M.V.; Caceres, M.I.; Herrera-Soto, A.; Arredondo, S.B.; Varas-Godoy, M.; van Zundert, B.; Varela-Nallar, L.

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778345

777552

36690445

Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis

2023

Demond, H.; Hanna, C.W.; Castillo-Fernandez, J.; Santos, F.; Papachristou, E.K.; Segonds-Pichon, A.; Kishore, K.; Andrews, S.; DSantos, C.S.; Kelsey, G.

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777955

33283949

Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer

2021

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The fungal-specific histone acetyltransferase Rtt109 regulates development, DNA damage response, and virulence in Aspergillus fumigatus

2021

Zhang, Y.; Fan, J.; Ye, J.; Lu, L.

Mol. Microbiol.

115

1191-1206

778582

38289455

Histone methyltransferase G9a plays an essential role on nicotine preference in zebrafish

2024

Faillace, M.; Ortiz, J.; Rocco, L.; Bernabeu, R.

Mol. Neurobiol.

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6245-6263

Links to other databases for [histone H3]-L-lysine9

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