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Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis
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Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP
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Counteraction by MutT protein of transcriptional errors caused by oxidative damage
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Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association
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Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance
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Investigation of MTH1 activity via mismatch-based DNA chain elongation
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Crystal structures and inhibitor interactions of mouse and dog MTH1 reveal species-specific differences in affinity
2018
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Biochemistry
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Crystal structure and substrate specificity of the 8-oxo-dGTP hydrolase NUDT1 from Arabidopsis thaliana
2019
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Biochemistry
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Crystal structure and substrate specificity of the 8-oxo-dGTP hydrolase NUDT1 from Arabidopsis thaliana
2019
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Biochemistry
58
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Insights into the substrate specificity of the MutT pyrophosphohydrolase using structural analogues of 8-oxo-2'-deoxyguanosine nucleotide
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Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors
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Inhibitory effect of 8-halogenated 7-deaza-2-deoxyguanosine triphosphates on human 8-oxo-2'-deoxyguanosine triphosphatase, hMTH1, activities
2016
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Inhibitory effect of 8-halogenated 7-deaza-2-deoxyguanosine triphosphates on human 8-oxo-2'-deoxyguanosine triphosphatase, hMTH1, activities
2016
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Structural and kinetic studies of the human Nudix hydrolase MTH1 reveal the mechanism for its broad substrate specificity
2017
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Structural and kinetic studies of the human Nudix hydrolase MTH1 reveal the mechanism for its broad substrate specificity
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Enzymatic characteristics of Nudix hydrolase 2 (Nud2), an 8-oxo-dGTP hydrolase from Myxococcus xanthus
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Structural insights into the specificity and catalytic mechanism of mycobacterial nucleotide pool sanitizing enzyme MutT2
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MTH1 substrate recognition - an example of specific promiscuity
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Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase
2022
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